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PTEN Loss Promotes Intratumoral Androgen Synthesis and Tumor Microenvironment Remodeling via Aberrant Activation of RUNX2 in Castration-Resistant Prostate Cancer

Clinical cancer research, 2018-02, Vol.24 (4), p.834-846

2018

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Fructose-1,6-bisphosphatase Inhibits ERK Activation and Bypasses Gemcitabine Resistance in Pancreatic Cancer by Blocking IQGAP1-MAPK Interaction

Cancer research (Chicago, Ill.), 2017-08, Vol.77 (16), p.4328-4341

2017

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SPOP mutation induces DNA methylation via stabilizing GLP/G9a

Nature communications, 2021-09, Vol.12 (1), p.5716-5716, Article 5716

2021

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HDAC5 Loss Impairs RB Repression of Pro-Oncogenic Genes and Confers CDK4/6 Inhibitor Resistance in Cancer

Cancer research (Chicago, Ill.), 2021-03, Vol.81 (6), p.1486-1499

2021

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Inhibiting histone deacetylases suppresses glucose metabolism and hepatocellular carcinoma growth by restoring FBP1 expression

Scientific reports, 2017-03, Vol.7 (1), p.43864-43864, Article 43864

2017

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TMPRSS2-ERG Controls Luminal Epithelial Lineage and Antiandrogen Sensitivity in PTEN and TP53 -Mutated Prostate Cancer

Clinical cancer research, 2018-09, Vol.24 (18), p.4551-4565

2018

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Destruction of DNA‐Binding Proteins by Programmable Oligonucleotide PROTAC (O'PROTAC): Effective Targeting of LEF1 and ERG

Advanced science, 2021-10, Vol.8 (20), p.e2102555-n/a

2021

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3-Aminophthalic acid, a new cereblon ligand for targeted protein degradation by O'PROTAC

Chemical communications (Cambridge, England), 2022-02, Vol.58 (14), p.2383-2386

2022

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Truncated ERG Oncoproteins from TMPRSS2-ERG Fusions Are Resistant to SPOP-Mediated Proteasome Degradation

Molecular cell, 2015-09, Vol.59 (6), p.904-916

2015

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Gain-of-function mutant p53 together with ERG proto-oncogene drive prostate cancer by beta-catenin activation and pyrimidine synthesis

Nature communications, 2023-08, Vol.14 (1), p.4671-19, Article 4671

2023

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Loss of FOXO1 Cooperates with TMPRSS2-ERG Overexpression to Promote Prostate Tumorigenesis and Cell Invasion

Cancer research (Chicago, Ill.), 2017-12, Vol.77 (23), p.6524-6537

2017

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p300 Acetyltransferase Regulates Androgen Receptor Degradation and PTEN-Deficient Prostate Tumorigenesis

Cancer research (Chicago, Ill.), 2014-03, Vol.74 (6), p.1870-1880

2014

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The novel BET‐CBP/p300 dual inhibitor NEO2734 is active in SPOP mutant and wild‐type prostate cancer

EMBO molecular medicine, 2019-11, Vol.11 (11), p.e10659-n/a

2019

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TRABID overexpression enables synthetic lethality to PARP inhibitor via prolonging 53BP1 retention at double-strand breaks

Nature communications, 2023-03, Vol.14 (1), p.1810-1810, Article 1810

2023

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FOXO1 Inhibits Runx2 Transcriptional Activity and Prostate Cancer Cell Migration and Invasion

Cancer research (Chicago, Ill.), 2011-05, Vol.71 (9), p.3257-3267

2011

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Inhibition of EZH2 by chemo- and radiotherapy agents and small molecule inhibitors induces cell death in castration-resistant prostate cancer

Oncotarget, 2016-01, Vol.7 (3), p.3440-3452

2016

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Dual inhibition of AKT‐mTOR and AR signaling by targeting HDAC3 in PTEN‐ or SPOP‐mutated prostate cancer

EMBO molecular medicine, 2018-04, Vol.10 (4), p.n/a

2018

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P300 acetyltransferase regulates fatty acid synthase expression, lipid metabolism and prostate cancer growth

Oncotarget, 2016-03, Vol.7 (12), p.15135-15149

2016

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Inhibition of Cyclin-Dependent Kinase Phosphorylation of FOXO1 and Prostate Cancer Cell Growth by a Peptide Derived from FOXO1

Neoplasia (New York, N.Y.), 2011-09, Vol.13 (9), p.854-863

2011

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CBP Loss Cooperates with PTEN Haploinsufficiency to Drive Prostate Cancer: Implications for Epigenetic Therapy

Cancer research (Chicago, Ill.), 2014-04, Vol.74 (7), p.2050-2061

2014

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Androgens repress expression of the f-box protein Skp2 via p107 dependent and independent mechanisms in LNCaP prostate cancer cells

The Prostate, 2012-02, Vol.72 (2), p.225-232

2012

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PTEN Induces Chemosensitivity in PTEN-mutated Prostate Cancer Cells by Suppression of Bcl-2 Expression

The Journal of biological chemistry, 2001-10, Vol.276 (42), p.38830-38836

2001

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Overexpression of c-Jun induced by quercetin and resverol inhibits the expression and function of the androgen receptor in human prostate cancer cells

Cancer letters, 2004-09, Vol.213 (2), p.155-163

2004

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AKT‐phosphorylated FOXO1 suppresses ERK activation and chemoresistance by disrupting IQGAP1‐MAPK interaction

The EMBO journal, 2017-04, Vol.36 (8), p.995-1010

2017

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Chemopreventive agents modulate the protein expression profile of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone plus benzo[a]pyrene-induced lung tumors in A/J mice

Carcinogenesis (New York), 2008-03, Vol.29 (3), p.610-619

2008

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PTEN Loss Promotes Intratumoral Androgen Synthesis and Tumor Microenvironment Remodeling via Aberrant Activation of RUNX2 in Castration-Resistant Prostate Cancer

Fructose-1,6-bisphosphatase Inhibits ERK Activation and Bypasses Gemcitabine Resistance in Pancreatic Cancer by Blocking IQGAP1-MAPK Interaction

SPOP mutation induces DNA methylation via stabilizing GLP/G9a

HDAC5 Loss Impairs RB Repression of Pro-Oncogenic Genes and Confers CDK4/6 Inhibitor Resistance in Cancer

Inhibiting histone deacetylases suppresses glucose metabolism and hepatocellular carcinoma growth by restoring FBP1 expression

TMPRSS2-ERG Controls Luminal Epithelial Lineage and Antiandrogen Sensitivity in PTEN and TP53 -Mutated Prostate Cancer

Destruction of DNA‐Binding Proteins by Programmable Oligonucleotide PROTAC (O'PROTAC): Effective Targeting of LEF1 and ERG

3-Aminophthalic acid, a new cereblon ligand for targeted protein degradation by O'PROTAC

Truncated ERG Oncoproteins from TMPRSS2-ERG Fusions Are Resistant to SPOP-Mediated Proteasome Degradation

Gain-of-function mutant p53 together with ERG proto-oncogene drive prostate cancer by beta-catenin activation and pyrimidine synthesis

Loss of FOXO1 Cooperates with TMPRSS2-ERG Overexpression to Promote Prostate Tumorigenesis and Cell Invasion

p300 Acetyltransferase Regulates Androgen Receptor Degradation and PTEN-Deficient Prostate Tumorigenesis

The novel BET‐CBP/p300 dual inhibitor NEO2734 is active in SPOP mutant and wild‐type prostate cancer

TRABID overexpression enables synthetic lethality to PARP inhibitor via prolonging 53BP1 retention at double-strand breaks

FOXO1 Inhibits Runx2 Transcriptional Activity and Prostate Cancer Cell Migration and Invasion

Inhibition of EZH2 by chemo- and radiotherapy agents and small molecule inhibitors induces cell death in castration-resistant prostate cancer

Dual inhibition of AKT‐mTOR and AR signaling by targeting HDAC3 in PTEN‐ or SPOP‐mutated prostate cancer

P300 acetyltransferase regulates fatty acid synthase expression, lipid metabolism and prostate cancer growth

Inhibition of Cyclin-Dependent Kinase Phosphorylation of FOXO1 and Prostate Cancer Cell Growth by a Peptide Derived from FOXO1

CBP Loss Cooperates with PTEN Haploinsufficiency to Drive Prostate Cancer: Implications for Epigenetic Therapy

Androgens repress expression of the f-box protein Skp2 via p107 dependent and independent mechanisms in LNCaP prostate cancer cells

PTEN Induces Chemosensitivity in PTEN-mutated Prostate Cancer Cells by Suppression of Bcl-2 Expression

Overexpression of c-Jun induced by quercetin and resverol inhibits the expression and function of the androgen receptor in human prostate cancer cells

AKT‐phosphorylated FOXO1 suppresses ERK activation and chemoresistance by disrupting IQGAP1‐MAPK interaction

Chemopreventive agents modulate the protein expression profile of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone plus benzo[a]pyrene-induced lung tumors in A/J mice

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