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Conversion of Human Choriogonadotropin into a Follitropin by Protein Engineering

Proceedings of the National Academy of Sciences - PNAS, 1991-02, Vol.88 (3), p.760-764

1991

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Co-evolution of ligand-receptor pairs

Nature (London), 1994-03, Vol.368 (6468), p.251-255

1994

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Desensitization and resensitization of lutropin receptors expressed in transfected Y-1 adrenal cells

Journal of endocrinology, 1999-11, Vol.163 (2), p.289-297

1999

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Chimeric proteins can exceed the sum of their parts : Implications for evolution and protein design

Nature biotechnology, 1997-05, Vol.15 (5), p.439-443

1997

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Localization of residues that confer antibody binding specificity using human chorionic gonadotropin/luteinizing hormone beta subunit chimeras and mutants

The Journal of biological chemistry, 1990-05, Vol.265 (15), p.8511-8518

1990

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Leutropin/beta-adrenergic receptor chimeras bind choriogonadotropin and adrenergic ligands but are not expressed at the cell surface

The Journal of biological chemistry, 1991-06, Vol.266 (17), p.10807-10812

1991

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Deglycosylation of a bifunctional lutropin-follitropin agonist reduced its follitropin activity more than its lutropin activity

Fertility and sterility, 1999-12, Vol.72 (6), p.1093-1099

1999

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Cloning of rat lutropin (LH) receptor analogs lacking the soybean lectin domain

Molecular and cellular endocrinology, 1990-07, Vol.71 (3), p.R19-R23

1990

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Use of Monoclonal Antibodies to Subunits of Human Chorionic Gonadotropin to Examine the Orientation of the Hormone in Its Complex with Receptor

Proceedings of the National Academy of Sciences - PNAS, 1982-04, Vol.79 (7), p.2245-2249

1982

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Model of Human Chorionic Gonadotropin and Lutropin Receptor Interaction That Explains Signal Transduction of the Glycoprotein Hormones (∗)

The Journal of biological chemistry, 1995-08, Vol.270 (34), p.20020-20031

1995

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Tight attachment of chitin-binding-domain-tagged proteins to surfaces coated with acetylated chitosan

Analytical biochemistry, 2004-04, Vol.327 (2), p.278-283

2004

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Detection of conformational changes in human chorionic gonadotropin upon binding to rat gonadal receptors

The Journal of biological chemistry, 1987-12, Vol.262 (35), p.16920-16926

1987

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Role of carbohydrate of human chorionic gonadotropin in the mechanism of hormone action

The Journal of biological chemistry, 1975-12, Vol.250 (23), p.9163-9169

1975

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Mixing two monoclonal antibodies yields enhanced affinity for antigen

The Journal of immunology (1950), 1982-06, Vol.128 (6), p.2709-2713

1982

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Alternatively folded choriogonadotropin analogs. Implications for hormone folding and biological activity

The Journal of biological chemistry, 2001-12, Vol.276 (50), p.46953

2001

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Threading of a glycosylated protein loop through a protein hole: Implications for combination of human chorionic gonadotropin subunits

Protein science, 2001-02, Vol.10 (2), p.226-235

2001

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A circular antibody-antigen complex is responsible for increased affinity shown by mixtures of monoclonal antibodies to human chorionic gonadotropin

The Journal of immunology (1950), 1983-10, Vol.131 (4), p.1900-1905

1983

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Bifunctional hCG analogs adopt different conformations in LH and FSH receptor complexes

Molecular and cellular endocrinology, 2000-12, Vol.170 (1), p.67-77

2000

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Lutropins appear to contact two independent sites in the extracellular domain of their receptors

Biochemical journal, 1998-11, Vol.335 ( Pt 3) (3), p.611-617

1998

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The surface of α-subunit loop 1 distant from the subunit interface is exposed in the hCG lutropin receptor complex

Biochimica et biophysica acta, 2000-07, Vol.1475 (3), p.390-394

2000

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Effect of LH on steroidogenesis and cyclic AMP accumulation in rat Leydig cell preparations and mouse tumor Leydig cells

Endocrinology (Philadelphia), 1973-07, Vol.93 (1), p.127-134

1973

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hCGβ Residues 94–96 alter LH activity without appearing to make key receptor contacts

Molecular and cellular endocrinology, 1996-11, Vol.124 (1), p.151-161

1996

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Assembly and expression of a synthetic gene encoding the bovine glycoprotein hormone α-subunit

Molecular and cellular endocrinology, 1992-02, Vol.83 (2), p.195-200

1992

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Further characterization of cooperative interactions of monoclonal antibodies

The Journal of immunology (1950), 1983-10, Vol.131 (4), p.1906-1912

1983

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Use of the average antibody-antigen bond concept and probability theory to simplify modeling of linear and circular antibody-antigen complex formation

Journal of immunological methods, 1985-11, Vol.84 (1), p.251-263

1985

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Conversion of Human Choriogonadotropin into a Follitropin by Protein Engineering

Co-evolution of ligand-receptor pairs

Desensitization and resensitization of lutropin receptors expressed in transfected Y-1 adrenal cells

Chimeric proteins can exceed the sum of their parts : Implications for evolution and protein design

Localization of residues that confer antibody binding specificity using human chorionic gonadotropin/luteinizing hormone beta subunit chimeras and mutants

Leutropin/beta-adrenergic receptor chimeras bind choriogonadotropin and adrenergic ligands but are not expressed at the cell surface

Deglycosylation of a bifunctional lutropin-follitropin agonist reduced its follitropin activity more than its lutropin activity

Cloning of rat lutropin (LH) receptor analogs lacking the soybean lectin domain

Use of Monoclonal Antibodies to Subunits of Human Chorionic Gonadotropin to Examine the Orientation of the Hormone in Its Complex with Receptor

Model of Human Chorionic Gonadotropin and Lutropin Receptor Interaction That Explains Signal Transduction of the Glycoprotein Hormones (∗)

Tight attachment of chitin-binding-domain-tagged proteins to surfaces coated with acetylated chitosan

Detection of conformational changes in human chorionic gonadotropin upon binding to rat gonadal receptors

Role of carbohydrate of human chorionic gonadotropin in the mechanism of hormone action

Mixing two monoclonal antibodies yields enhanced affinity for antigen

Alternatively folded choriogonadotropin analogs. Implications for hormone folding and biological activity

Threading of a glycosylated protein loop through a protein hole: Implications for combination of human chorionic gonadotropin subunits

A circular antibody-antigen complex is responsible for increased affinity shown by mixtures of monoclonal antibodies to human chorionic gonadotropin

Bifunctional hCG analogs adopt different conformations in LH and FSH receptor complexes

Lutropins appear to contact two independent sites in the extracellular domain of their receptors

The surface of α-subunit loop 1 distant from the subunit interface is exposed in the hCG lutropin receptor complex

Effect of LH on steroidogenesis and cyclic AMP accumulation in rat Leydig cell preparations and mouse tumor Leydig cells

hCGβ Residues 94–96 alter LH activity without appearing to make key receptor contacts

Assembly and expression of a synthetic gene encoding the bovine glycoprotein hormone α-subunit

Further characterization of cooperative interactions of monoclonal antibodies

Use of the average antibody-antigen bond concept and probability theory to simplify modeling of linear and circular antibody-antigen complex formation

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