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Translating IL-6 biology into effective treatments

Nature reviews. Rheumatology, 2020-06, Vol.16 (6), p.335-345

2020

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IL-6/IL-6 receptor system and its role in physiological and pathological conditions

Clinical science (1979), 2012-02, Vol.122 (4), p.143

2012

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High molecular weight hyaluronic acid inhibits IL-6-induced MMP production from human chondrocytes by up-regulating the ERK inhibitor, MKP-1

Biochemical and biophysical research communications, 2010-12, Vol.403 (2), p.184-189

2010

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The Roles of Interleukin-6 in the Pathogenesis of Rheumatoid Arthritis

Arthritis, 2011-01, Vol.2011, p.765624-8

2011

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A phase 2 study of polatuzumab vedotin + bendamustine + rituximab in relapsed/refractory diffuse large B‐cell lymphoma

Cancer science, 2021-07, Vol.112 (7), p.2845-2854

2021

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Baseline Serum Osteopontin Levels Predict the Clinical Effectiveness of Tocilizumab but Not Infliximab in Biologic-Naïve Patients with Rheumatoid Arthritis: A Single-Center Prospective Study at 1 Year (the Keio First-Bio Cohort Study)

PloS one, 2015-12, Vol.10 (12), p.e0145468-e0145468

2015

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Anti‐interleukin‐6 receptor antibody prevents systemic bone mass loss via reducing the number of osteoclast precursors in bone marrow in a collagen‐induced arthritis model

Clinical and experimental immunology, 2014-02, Vol.175 (2), p.172-180

2014

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Tocilizumab, A Humanized Anti-IL-6R Antibody, as an Emerging Therapeutic Option for Rheumatoid Arthritis: Molecular and Cellular Mechanistic Insights

International Reviews of Immunology, 2015-05, Vol.34 (3), p.265-279

2015

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Tocilizumab, a Humanized Anti-interleukin-6 Receptor Antibody, Ameliorates Joint Swelling in Established Monkey Collagen-Induced Arthritis

Biological and Pharmaceutical Bulletin, 2008/06/01, Vol.31(6), pp.1159-1163

2008

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Correction: Baseline Serum Osteopontin Levels Predict the Clinical Effectiveness of Tocilizumab but Not Infliximab in Biologic-Naïve Patients with Rheumatoid Arthritis: A Single-Center Prospective Study at 1 Year (the Keio First-Bio Cohort Study)

PloS one, 2016, Vol.11 (3), p.e0152341-e0152341

2016

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High molecular weight hyaluronic acid relieved joint pain and prevented the progression of cartilage degeneration in a rabbit osteoarthritis model after onset of arthritis

Modern rheumatology, 2010-10, Vol.20 (5), p.432-438

2010

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Anti-inflammatory mechanism of tocilizumab, a humanized anti-IL-6R antibody: effect on the expression of chemokine and adhesion molecule

Rheumatology international, 2010-01, Vol.30 (3), p.309-315

2010

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Discriminating phenotypic signatures identified for tocilizumab, adalimumab, and tofacitinib monotherapy and their combinations with methotrexate

Journal of translational medicine, 2018-06, Vol.16 (1), p.156-156, Article 156

2018

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Atherogenic effects of TNF-α and IL-6 via up-regulation of scavenger receptors

Cytokine (Philadelphia, Pa.), 2012-06, Vol.58 (3), p.424-430

2012

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Induction of high-dose tolerance to the rat anti-mouse IL-6 receptor antibody in NZB/NZW F1 mice

Rheumatology international, 2011-11, Vol.31 (11), p.1445-1449

2011

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Blockade of IL-6 and TNF-α inhibited oxLDL-induced production of MCP-1 via scavenger receptor induction

European journal of pharmacology, 2012-08, Vol.689 (1-3), p.249-254

2012

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Interleukin-6 regulates anti-arthritic effect of methotrexate via reduction of SLC19A1 expression in a mouse arthritis model

Arthritis research & therapy, 2012-04, Vol.14 (2), p.R96-R96

2012

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Striking Species Difference in the Contribution of Concentrative Nucleoside Transporter 2 to Nucleoside Uptake between Mouse and Rat Hepatocytes

Antimicrobial Agents and Chemotherapy, 2010-07, Vol.54 (7), p.3035-3038

2010

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Peripheral blood CD4(+)CD25(+)CD127(low) regulatory T cells are significantly increased by tocilizumab treatment in patients with rheumatoid arthritis: increase in regulatory T cells correlates with clinical response

Arthritis research & therapy, 2015-01, Vol.17, p.10-10

2015

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IL-6 and lipid metabolism

Inflammation and Regeneration, 2011, Vol.31(3), pp.325-333

2011

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High molecular weight hyaluronic acid relieved joint pain and prevented the progression of cartilage degeneration in a rabbit osteoarthritis model after onset of arthritis

Modern rheumatology, 2010-10, Vol.20 (5), p.432-438

2010

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IL-6 plays an essential role in neutrophilia under inflammation

Cytokine (Philadelphia, Pa.), 2011-04, Vol.54 (1), p.92-99

2011

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Baseline levels of soluble interleukin-6 receptor predict clinical remission in patients with rheumatoid arthritis treated with tocilizumab: implications for molecular targeted therapy

Annals of the rheumatic diseases, 2014-05, Vol.73 (5), p.945-947

2014

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Characterization of ribavirin uptake systems in human hepatocytes

Journal of hepatology, 2010-04, Vol.52 (4), p.486-492

2010

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IL-6 as a target in autoimmune disease and inflammation

Folia Pharmacologica Japonica, 2014, Vol.144(4), pp.172-177

2014

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Translating IL-6 biology into effective treatments

IL-6/IL-6 receptor system and its role in physiological and pathological conditions

High molecular weight hyaluronic acid inhibits IL-6-induced MMP production from human chondrocytes by up-regulating the ERK inhibitor, MKP-1

The Roles of Interleukin-6 in the Pathogenesis of Rheumatoid Arthritis

A phase 2 study of polatuzumab vedotin + bendamustine + rituximab in relapsed/refractory diffuse large B‐cell lymphoma

Baseline Serum Osteopontin Levels Predict the Clinical Effectiveness of Tocilizumab but Not Infliximab in Biologic-Naïve Patients with Rheumatoid Arthritis: A Single-Center Prospective Study at 1 Year (the Keio First-Bio Cohort Study)

Anti‐interleukin‐6 receptor antibody prevents systemic bone mass loss via reducing the number of osteoclast precursors in bone marrow in a collagen‐induced arthritis model

Tocilizumab, A Humanized Anti-IL-6R Antibody, as an Emerging Therapeutic Option for Rheumatoid Arthritis: Molecular and Cellular Mechanistic Insights

Tocilizumab, a Humanized Anti-interleukin-6 Receptor Antibody, Ameliorates Joint Swelling in Established Monkey Collagen-Induced Arthritis

Correction: Baseline Serum Osteopontin Levels Predict the Clinical Effectiveness of Tocilizumab but Not Infliximab in Biologic-Naïve Patients with Rheumatoid Arthritis: A Single-Center Prospective Study at 1 Year (the Keio First-Bio Cohort Study)

High molecular weight hyaluronic acid relieved joint pain and prevented the progression of cartilage degeneration in a rabbit osteoarthritis model after onset of arthritis

Anti-inflammatory mechanism of tocilizumab, a humanized anti-IL-6R antibody: effect on the expression of chemokine and adhesion molecule

Discriminating phenotypic signatures identified for tocilizumab, adalimumab, and tofacitinib monotherapy and their combinations with methotrexate

Atherogenic effects of TNF-α and IL-6 via up-regulation of scavenger receptors

Induction of high-dose tolerance to the rat anti-mouse IL-6 receptor antibody in NZB/NZW F1 mice

Blockade of IL-6 and TNF-α inhibited oxLDL-induced production of MCP-1 via scavenger receptor induction

Interleukin-6 regulates anti-arthritic effect of methotrexate via reduction of SLC19A1 expression in a mouse arthritis model

Striking Species Difference in the Contribution of Concentrative Nucleoside Transporter 2 to Nucleoside Uptake between Mouse and Rat Hepatocytes

Peripheral blood CD4(+)CD25(+)CD127(low) regulatory T cells are significantly increased by tocilizumab treatment in patients with rheumatoid arthritis: increase in regulatory T cells correlates with clinical response

IL-6 and lipid metabolism

High molecular weight hyaluronic acid relieved joint pain and prevented the progression of cartilage degeneration in a rabbit osteoarthritis model after onset of arthritis

IL-6 plays an essential role in neutrophilia under inflammation

Baseline levels of soluble interleukin-6 receptor predict clinical remission in patients with rheumatoid arthritis treated with tocilizumab: implications for molecular targeted therapy

Characterization of ribavirin uptake systems in human hepatocytes

IL-6 as a target in autoimmune disease and inflammation

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