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'Seed' analysis of off-target siRNAs reveals an essential role of Mcl-1 in resistance to the small-molecule Bcl-2/Bcl-XL inhibitor ABT-737

Oncogene, 2007-06, Vol.26 (27), p.3972-3979

2007

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Tumor vasculature is a key determinant for the efficiency of nanoparticle-mediated siRNA delivery

Gene therapy, 2012-07, Vol.19 (7), p.775-780

2012

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Privileged Molecules for Protein Binding Identified from NMR-Based Screening

Journal of medicinal chemistry, 2000-09, Vol.43 (18), p.3443-3447

2000

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Discovering High-Affinity Ligands for Proteins: SAR by NMR

Science (American Association for the Advancement of Science), 1996-11, Vol.274 (5292), p.1531-1534

1996

Volltextzugriff (PDF)

Myeloid cell leukemia-1 is an important apoptotic survival factor in triple-negative breast cancer

Cell death and differentiation, 2015-12, Vol.22 (12), p.2098-2106

2015

Volltextzugriff (PDF)

Novel p-Arylthio Cinnamides as Antagonists of Leukocyte Function-Associated Antigen-1/Intracellular Adhesion Molecule-1 Interaction. 2. Mechanism of Inhibition and Structure-Based Improvement of Pharmaceutical Properties

Journal of medicinal chemistry, 2001-04, Vol.44 (8), p.1202-1210

2001

Volltextzugriff (PDF)

RNAi-based screening of the human kinome identifies Akt-cooperating kinases: a new approach to designing efficacious multitargeted kinase inhibitors

Oncogene, 2006-03, Vol.25 (9), p.1340-1348

2006

Volltextzugriff (PDF)

NMR structure and mutagenesis of the inhibitor-of-apoptosis protein XIAP

Nature (London), 1999-10, Vol.401 (6755), p.818-822

1999

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Discovery of Potent Nonpeptide Inhibitors of Stromelysin Using SAR by NMR

Journal of the American Chemical Society, 1997-06, Vol.119 (25), p.5818-5827

1997

Volltextzugriff (PDF)

Pleckstrin homology domains bind to phosphatidylinositol-4,5-bisphosphate

Nature (London), 1994-09, Vol.371 (6493), p.168-170

1994

Volltextzugriff (PDF)

High-Throughput Nuclear Magnetic Resonance-Based Screening

Journal of medicinal chemistry, 1999-07, Vol.42 (13), p.2315-2317

1999

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Druggability Indices for Protein Targets Derived from NMR-Based Screening Data

Journal of medicinal chemistry, 2005-04, Vol.48 (7), p.2518-2525

2005

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Rational Design of Diflunisal Analogues with Reduced Affinity for Human Serum Albumin

Journal of the American Chemical Society, 2001-10, Vol.123 (43), p.10429-10435

2001

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NMR structure and mutagenesis of the FADD (Mort1) death-effector domain

Nature (London), 1998-04, Vol.392 (6679), p.941-945

1998

Volltextzugriff (PDF)

Insights into Programmed Cell Death through Structural Biology

Cell, 2000-10, Vol.103 (2), p.273-282

Fesik, Stephen W.

2000

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Evaluation of PMF Scoring in Docking Weak Ligands to the FK506 Binding Protein

Journal of medicinal chemistry, 1999-07, Vol.42 (14), p.2498-2503

1999

Volltextzugriff (PDF)

Specificity of Short Interfering RNA Determined through Gene Expression Signatures

Proceedings of the National Academy of Sciences - PNAS, 2003-05, Vol.100 (11), p.6347-6352

2003

Volltextzugriff (PDF)

Structure and ligand recognition of the phosphotyrosine binding domain of Shc

Nature (London), 1995-12, Vol.378 (6557), p.584-592

1995

Volltextzugriff (PDF)

Novel Inhibitors of Erm Methyltransferases from NMR and Parallel Synthesis

Journal of medicinal chemistry, 1999-09, Vol.42 (19), p.3852-3859

1999

Volltextzugriff (PDF)

Identification of Novel Inhibitors of Urokinase via NMR-Based Screening

Journal of medicinal chemistry, 2000-10, Vol.43 (21), p.3862-3866

2000

Volltextzugriff (PDF)

Structural Basis for the Inhibition of Caspase-3 by XIAP

Cell, 2001-03, Vol.104 (5), p.791-800

2001

Volltextzugriff (PDF)

Structural basis for binding of Smac/DIABLO to the XIAP BIR3 domain

Nature (London), 2000-12, Vol.408 (6815), p.1004-1008

2000

Volltextzugriff (PDF)

NMR-Based Discovery of Lead Inhibitors That Block DNA Binding of the Human Papillomavirus E2 Protein

Journal of medicinal chemistry, 1997-09, Vol.40 (20), p.3144-3150

1997

Volltextzugriff (PDF)

Design of Adenosine Kinase Inhibitors from the NMR-Based Screening of Fragments

Journal of medicinal chemistry, 2000-12, Vol.43 (25), p.4781-4786

2000

Volltextzugriff (PDF)

Structure of the N-Terminal RNA-Binding Domain of the SARS CoV Nucleocapsid Protein

Biochemistry (Easton), 2004-05, Vol.43 (20), p.6059-6063

2004

Volltextzugriff (PDF)

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'Seed' analysis of off-target siRNAs reveals an essential role of Mcl-1 in resistance to the small-molecule Bcl-2/Bcl-XL inhibitor ABT-737

Tumor vasculature is a key determinant for the efficiency of nanoparticle-mediated siRNA delivery

Privileged Molecules for Protein Binding Identified from NMR-Based Screening

Discovering High-Affinity Ligands for Proteins: SAR by NMR

Myeloid cell leukemia-1 is an important apoptotic survival factor in triple-negative breast cancer

Novel p-Arylthio Cinnamides as Antagonists of Leukocyte Function-Associated Antigen-1/Intracellular Adhesion Molecule-1 Interaction. 2. Mechanism of Inhibition and Structure-Based Improvement of Pharmaceutical Properties

RNAi-based screening of the human kinome identifies Akt-cooperating kinases: a new approach to designing efficacious multitargeted kinase inhibitors

NMR structure and mutagenesis of the inhibitor-of-apoptosis protein XIAP

Discovery of Potent Nonpeptide Inhibitors of Stromelysin Using SAR by NMR

Pleckstrin homology domains bind to phosphatidylinositol-4,5-bisphosphate

High-Throughput Nuclear Magnetic Resonance-Based Screening

Druggability Indices for Protein Targets Derived from NMR-Based Screening Data

Rational Design of Diflunisal Analogues with Reduced Affinity for Human Serum Albumin

NMR structure and mutagenesis of the FADD (Mort1) death-effector domain

Insights into Programmed Cell Death through Structural Biology

Evaluation of PMF Scoring in Docking Weak Ligands to the FK506 Binding Protein

Specificity of Short Interfering RNA Determined through Gene Expression Signatures

Structure and ligand recognition of the phosphotyrosine binding domain of Shc

Novel Inhibitors of Erm Methyltransferases from NMR and Parallel Synthesis

Identification of Novel Inhibitors of Urokinase via NMR-Based Screening

Structural Basis for the Inhibition of Caspase-3 by XIAP

Structural basis for binding of Smac/DIABLO to the XIAP BIR3 domain

NMR-Based Discovery of Lead Inhibitors That Block DNA Binding of the Human Papillomavirus E2 Protein

Design of Adenosine Kinase Inhibitors from the NMR-Based Screening of Fragments

Structure of the N-Terminal RNA-Binding Domain of the SARS CoV Nucleocapsid Protein

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