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Isotope chemistry; a useful tool in the drug discovery arsenal

Bioorganic & medicinal chemistry letters, 2015-01, Vol.25 (2), p.167-171

2015

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Apolipoprotein E Binding Drives Structural and Compositional Rearrangement of mRNA-Containing Lipid Nanoparticles

ACS nano, 2021-04, Vol.15 (4), p.6709-6722

2021

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Computationally-Guided Development of a Chelated NHC‑P Iridium(I) Complex for the Directed Hydrogen Isotope Exchange of Aryl Sulfones

ACS catalysis, 2020-10, Vol.10 (19), p.11120-11126

2020

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New trends and applications in carboxylation for isotope chemistry

Journal of labelled compounds & radiopharmaceuticals, 2018-11, Vol.61 (13), p.934-948

2018

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Structure-enantioselectivity effects in 3,4-dihydropyrimido[2,1-b]benzothiazole-based isothioureas as enantioselective acylation catalysts

Organic & biomolecular chemistry, 2011-01, Vol.9 (2), p.559-570

2011

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Disposition of orally administered atuliflapon, a novel 5‐lipoxygenase‐activating protein inhibitor in healthy participants

Pharmacology research & perspectives, 2024-10, Vol.12 (5), p.e70029-n/a

2024

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Isothiourea-Mediated Asymmetric O- to C-Carboxyl Transfer of Oxazolyl Carbonates: Structure-Selectivity Profiles and Mechanistic Studies

Chemistry : a European journal, 2012-02, Vol.18 (8), p.2398-2408

2012

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Isothiourea-Mediated Stereoselective C-Acylation of Silyl Ketene Acetals

Organic letters, 2010-06, Vol.12 (11), p.2660-2663

2010

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A Phase I Study To Determine the Absolute Bioavailability and Absorption, Distribution, Metabolism, and Excretion of Capivasertib in Healthy Male Participants

Drug metabolism and disposition, 2024-09, Vol.52 (9), p.939-948

2024

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Selective Deuteration and Tritiation of Pharmaceutically Relevant Sulfoximines

Angewandte Chemie International Edition, 2024-10, p.e202417179

2024

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Mass Balance and Absorption, Distribution, Metabolism, and Excretion Properties of Balcinrenone following Oral Administration in Combination with Intravenous Microtracer in Healthy Subjects

Drug metabolism and disposition, 2023-08, Vol.51 (8), p.995-1004

2023

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Synthesis of Stable Isotope, Tritiated, and Carbon‐14 Labeled Balcinrenone

Journal of labelled compounds & radiopharmaceuticals, 2024-04, Vol.67 (4), p.145-153

2024

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Application of Accelerator Mass Spectrometry to Characterize the Mass Balance Recovery and Disposition of AZD4831, a Novel Myeloperoxidase Inhibitor, following Administration of an Oral Radiolabeled Microtracer Dose in Humans

Drug metabolism and disposition, 2023-04, Vol.51 (4), p.451-463

2023

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Aortic Binding of AZD5248: Mechanistic Insight and Reactivity Assays To Support Lead Optimzation

Chemical research in toxicology, 2015-10, Vol.28 (10), p.1991-1999

2015

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Stereodynamics of Bond Rotation in Tertiary Aromatic Amides

Chemistry : a European journal, 2002-03, Vol.8 (6), p.1279-1289

2002

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Microbiome-derived carnitine mimics as previously unknown mediators of gut-brain axis communication

Science advances, 2020-03, Vol.6 (11), p.eaax6328-eaax6328

2020

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Using Symmetry to Monitor Geared Bond Rotation in Aromatic Amides by Dynamic NMR

Organic letters, 2000-10, Vol.2 (21), p.3351-3354

2000

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Isothiourea-Catalysed Asymmetric C-Acylation of Silyl Ketene Acetals

Chemistry : a European journal, 2011-09, Vol.17 (39), p.11060-11067

2011

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Isotope labelling by reduction of nitriles: Application to the synthesis of isotopologues of tolmetin and celecoxib

Journal of labelled compounds & radiopharmaceuticals, 2017-04, Vol.60 (4), p.213-220

2017

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The synthesis of tritium, carbon-14 and stable isotope labelled selective estrogen receptor degraders

Journal of labelled compounds & radiopharmaceuticals, 2016-09, Vol.59 (11), p.454-461

2016

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Structure–activity relationships of the peptide deformylase inhibitor BB-3497: modification of the methylene spacer and the P1′ side chain

Bioorganic & medicinal chemistry letters, 2003-08, Vol.13 (16), p.2709-2713

2003

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The synthesis of a tritium, carbon‐14, and stable isotope‐labeled cathepsin C inhibitors

Journal of labelled compounds & radiopharmaceuticals, 2017-02, Vol.60 (2), p.124-129

2017

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A convenient new synthesis of quaternary ammonium glucuronides of drug molecules

Tetrahedron, 2010-01, Vol.66 (2), p.537-541

2010

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Barriers to rotation about the chiral axis of tertiary aromatic amides

Tetrahedron, 1998-10, Vol.54 (43), p.13277-13294

1998

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Syntheses and structures of anomeric quaternary ammonium β-glucosides and comments on the anomeric C–N bond lengths

Tetrahedron, 2009-08, Vol.65 (32), p.6396-6402

2009

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Isotope chemistry; a useful tool in the drug discovery arsenal

Apolipoprotein E Binding Drives Structural and Compositional Rearrangement of mRNA-Containing Lipid Nanoparticles

Computationally-Guided Development of a Chelated NHC‑P Iridium(I) Complex for the Directed Hydrogen Isotope Exchange of Aryl Sulfones

New trends and applications in carboxylation for isotope chemistry

Structure-enantioselectivity effects in 3,4-dihydropyrimido[2,1-b]benzothiazole-based isothioureas as enantioselective acylation catalysts

Disposition of orally administered atuliflapon, a novel 5‐lipoxygenase‐activating protein inhibitor in healthy participants

Isothiourea-Mediated Asymmetric O- to C-Carboxyl Transfer of Oxazolyl Carbonates: Structure-Selectivity Profiles and Mechanistic Studies

Isothiourea-Mediated Stereoselective C-Acylation of Silyl Ketene Acetals

A Phase I Study To Determine the Absolute Bioavailability and Absorption, Distribution, Metabolism, and Excretion of Capivasertib in Healthy Male Participants

Selective Deuteration and Tritiation of Pharmaceutically Relevant Sulfoximines

Mass Balance and Absorption, Distribution, Metabolism, and Excretion Properties of Balcinrenone following Oral Administration in Combination with Intravenous Microtracer in Healthy Subjects

Synthesis of Stable Isotope, Tritiated, and Carbon‐14 Labeled Balcinrenone

Application of Accelerator Mass Spectrometry to Characterize the Mass Balance Recovery and Disposition of AZD4831, a Novel Myeloperoxidase Inhibitor, following Administration of an Oral Radiolabeled Microtracer Dose in Humans

Aortic Binding of AZD5248: Mechanistic Insight and Reactivity Assays To Support Lead Optimzation

Stereodynamics of Bond Rotation in Tertiary Aromatic Amides

Microbiome-derived carnitine mimics as previously unknown mediators of gut-brain axis communication

Using Symmetry to Monitor Geared Bond Rotation in Aromatic Amides by Dynamic NMR

Isothiourea-Catalysed Asymmetric C-Acylation of Silyl Ketene Acetals

Isotope labelling by reduction of nitriles: Application to the synthesis of isotopologues of tolmetin and celecoxib

The synthesis of tritium, carbon-14 and stable isotope labelled selective estrogen receptor degraders

Structure–activity relationships of the peptide deformylase inhibitor BB-3497: modification of the methylene spacer and the P1′ side chain

The synthesis of a tritium, carbon‐14, and stable isotope‐labeled cathepsin C inhibitors

A convenient new synthesis of quaternary ammonium glucuronides of drug molecules

Barriers to rotation about the chiral axis of tertiary aromatic amides

Syntheses and structures of anomeric quaternary ammonium β-glucosides and comments on the anomeric C–N bond lengths

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