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Adenosine Deaminases Acting on RNA Downregulate the Expression of Constitutive Androstane Receptor in the Human Liver-Derived Cells by Attenuating Splicing

The Journal of pharmacology and experimental therapeutics, 2019-09, Vol.370 (3), p.408-415

2019

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Genetic predictors of interindividual variability in hepatic CYP3A4 expression

The Journal of pharmacology and experimental therapeutics, 2010-03, Vol.332 (3), p.1088-1099

2010

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Camptothecin attenuates cytochrome P450 3A4 induction by blocking the activation of human pregnane X receptor

The Journal of pharmacology and experimental therapeutics, 2010-09, Vol.334 (3), p.999-1008

2010

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Pharmacokinetic-pharmacodynamic modeling of rifampicin-mediated Cyp3a11 induction in steroid and xenobiotic X receptor humanized mice

The Journal of pharmacology and experimental therapeutics, 2011-04, Vol.337 (1), p.75-82

2011

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Up-regulation of transporters and enzymes by the vitamin D receptor ligands, 1alpha,25-dihydroxyvitamin D3 and vitamin D analogs, in the Caco-2 cell monolayer

The Journal of pharmacology and experimental therapeutics, 2009-08, Vol.330 (2), p.389

2009

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Immunochemical detection of cytochrome P450 enzymes in liver microsomes of 27 cynomolgus monkeys

The Journal of pharmacology and experimental therapeutics, 2011-11, Vol.339 (2), p.654-661

2011

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Induction of drug metabolism enzymes and MDR1 using a novel human hepatocyte cell line

The Journal of pharmacology and experimental therapeutics, 2004-04, Vol.309 (1), p.303-309

2004

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Unmasking the dynamic interplay between intestinal P-glycoprotein and CYP3A4

The Journal of pharmacology and experimental therapeutics, 2002-03, Vol.300 (3), p.1036-1045

2002

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Human organic anion transporting polypeptide-C (SLC21A6) is a major determinant of rifampin-mediated pregnane X receptor activation

The Journal of pharmacology and experimental therapeutics, 2003-01, Vol.304 (1), p.223-228

2003

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Variability of CYP3A7 expression in human fetal liver

The Journal of pharmacology and experimental therapeutics, 2005-08, Vol.314 (2), p.626-635

2005

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Correlation of gene expression of ten drug efflux proteins of the ATP-binding cassette transporter family in normal human jejunum and in human intestinal epithelial Caco-2 cell monolayers

The Journal of pharmacology and experimental therapeutics, 2001-10, Vol.299 (1), p.164

2001

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Major role of human liver microsomal cytochrome P450 2C9 (CYP2C9) in the oxidative metabolism of celecoxib, a novel cyclooxygenase-II inhibitor

The Journal of pharmacology and experimental therapeutics, 2000-05, Vol.293 (2), p.453

2000

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Competition between cytochrome P-450 isozymes for NADPH-cytochrome P-450 oxidoreductase affects drug metabolism

The Journal of pharmacology and experimental therapeutics, 1999-05, Vol.289 (2), p.661

1999

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Mechanism-based inactivation of CYP3A by HIV protease inhibitors

The Journal of pharmacology and experimental therapeutics, 2005-02, Vol.312 (2), p.583-591

2005

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Selectivity of the multidrug resistance modulator, LY335979, for P-glycoprotein and effect on cytochrome P-450 activities

The Journal of pharmacology and experimental therapeutics, 1999-08, Vol.290 (2), p.854

1999

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A cell-based reporter gene assay for determining induction of CYP3A4 in a high-volume system

The Journal of pharmacology and experimental therapeutics, 2002-10, Vol.303 (1), p.412-423

2002

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Avasimibe induces CYP3A4 and multiple drug resistance protein 1 gene expression through activation of the pregnane X receptor

The Journal of pharmacology and experimental therapeutics, 2003-09, Vol.306 (3), p.1027-1034

2003

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The involvement of the pregnane X receptor in hepatic gene regulation during inflammation in mice

The Journal of pharmacology and experimental therapeutics, 2005-02, Vol.312 (2), p.841-848

2005

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Midazolam is a phenobarbital-like cytochrome p450 inducer in rats

The Journal of pharmacology and experimental therapeutics, 2001-12, Vol.299 (3), p.921

2001

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Activation of cytochrome P450 gene expression in the rat brain by phenobarbital-like inducers

The Journal of pharmacology and experimental therapeutics, 2000-09, Vol.294 (3), p.916

2000

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Regulation of CYP3A5 by glucocorticoids and cigarette smoke in human lung-derived cells

The Journal of pharmacology and experimental therapeutics, 2003-02, Vol.304 (2), p.745-752

2003

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Metabolism of methadone and levo-alpha-acetylmethadol (LAAM) by human intestinal cytochrome P450 3A4 (CYP3A4): potential contribution of intestinal metabolism to presystemic clearance and bioactivation

The Journal of pharmacology and experimental therapeutics, 2001-09, Vol.298 (3), p.1021

2001

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Guggulsterone activates multiple nuclear receptors and induces CYP3A gene expression through the pregnane X receptor

The Journal of pharmacology and experimental therapeutics, 2004-08, Vol.310 (2), p.528-535

2004

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Insulin differentially affects xenobiotic-enhanced, cytochrome P-450 (CYP)2E1, CYP2B, CYP3A, and CYP4A expression in primary cultured rat hepatocytes

The Journal of pharmacology and experimental therapeutics, 1999-05, Vol.289 (2), p.1121

1999

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O-Dealkylation of fluoxetine in relation to CYP2C19 gene dose and involvement of CYP3A4 in human liver microsomes

The Journal of pharmacology and experimental therapeutics, 2002-01, Vol.300 (1), p.105-111

2002

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Adenosine Deaminases Acting on RNA Downregulate the Expression of Constitutive Androstane Receptor in the Human Liver-Derived Cells by Attenuating Splicing

Genetic predictors of interindividual variability in hepatic CYP3A4 expression

Camptothecin attenuates cytochrome P450 3A4 induction by blocking the activation of human pregnane X receptor

Pharmacokinetic-pharmacodynamic modeling of rifampicin-mediated Cyp3a11 induction in steroid and xenobiotic X receptor humanized mice

Up-regulation of transporters and enzymes by the vitamin D receptor ligands, 1alpha,25-dihydroxyvitamin D3 and vitamin D analogs, in the Caco-2 cell monolayer

Immunochemical detection of cytochrome P450 enzymes in liver microsomes of 27 cynomolgus monkeys

Induction of drug metabolism enzymes and MDR1 using a novel human hepatocyte cell line

Unmasking the dynamic interplay between intestinal P-glycoprotein and CYP3A4

Human organic anion transporting polypeptide-C (SLC21A6) is a major determinant of rifampin-mediated pregnane X receptor activation

Variability of CYP3A7 expression in human fetal liver

Correlation of gene expression of ten drug efflux proteins of the ATP-binding cassette transporter family in normal human jejunum and in human intestinal epithelial Caco-2 cell monolayers

Major role of human liver microsomal cytochrome P450 2C9 (CYP2C9) in the oxidative metabolism of celecoxib, a novel cyclooxygenase-II inhibitor

Competition between cytochrome P-450 isozymes for NADPH-cytochrome P-450 oxidoreductase affects drug metabolism

Mechanism-based inactivation of CYP3A by HIV protease inhibitors

Selectivity of the multidrug resistance modulator, LY335979, for P-glycoprotein and effect on cytochrome P-450 activities

A cell-based reporter gene assay for determining induction of CYP3A4 in a high-volume system

Avasimibe induces CYP3A4 and multiple drug resistance protein 1 gene expression through activation of the pregnane X receptor

The involvement of the pregnane X receptor in hepatic gene regulation during inflammation in mice

Midazolam is a phenobarbital-like cytochrome p450 inducer in rats

Activation of cytochrome P450 gene expression in the rat brain by phenobarbital-like inducers

Regulation of CYP3A5 by glucocorticoids and cigarette smoke in human lung-derived cells

Metabolism of methadone and levo-alpha-acetylmethadol (LAAM) by human intestinal cytochrome P450 3A4 (CYP3A4): potential contribution of intestinal metabolism to presystemic clearance and bioactivation

Guggulsterone activates multiple nuclear receptors and induces CYP3A gene expression through the pregnane X receptor

Insulin differentially affects xenobiotic-enhanced, cytochrome P-450 (CYP)2E1, CYP2B, CYP3A, and CYP4A expression in primary cultured rat hepatocytes

O-Dealkylation of fluoxetine in relation to CYP2C19 gene dose and involvement of CYP3A4 in human liver microsomes

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