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Prediction of Altered Bile Acid Disposition Due to Inhibition of Multiple Transporters: An Integrated Approach Using Sandwich-Cultured Hepatocytes, Mechanistic Modeling, and Simulation
The Journal of pharmacology and experimental therapeutics, 2016-08, Vol.358 (2), p.324
2016
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Species differences in hepatobiliary disposition of taurocholic acid in human and rat sandwich-cultured hepatocytes: implications for drug-induced liver injury
The Journal of pharmacology and experimental therapeutics, 2015-05, Vol.353 (2), p.415
2015
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Hepatic basolateral efflux contributes significantly to rosuvastatin disposition II: characterization of hepatic elimination by basolateral, biliary, and metabolic clearance pathways in rat isolated perfused liver
The Journal of pharmacology and experimental therapeutics, 2013-12, Vol.347 (3), p.737
2013
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Hepatic basolateral efflux contributes significantly to rosuvastatin disposition I: characterization of basolateral versus biliary clearance using a novel protocol in sandwich-cultured hepatocytes
The Journal of pharmacology and experimental therapeutics, 2013-12, Vol.347 (3), p.727
2013
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Hepatobiliary disposition of troglitazone and metabolites in rat and human sandwich-cultured hepatocytes: use of Monte Carlo simulations to assess the impact of changes in biliary excretion on troglitazone sulfate accumulation
The Journal of pharmacology and experimental therapeutics, 2010-01, Vol.332 (1), p.26
2010
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Differential inhibition of rat and human Na+-dependent taurocholate cotransporting polypeptide (NTCP/SLC10A1)by bosentan: a mechanism for species differences in hepatotoxicity
The Journal of pharmacology and experimental therapeutics, 2007-06, Vol.321 (3), p.1170
2007
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Differential involvement of Mrp2 (Abcc2) and Bcrp (Abcg2) in biliary excretion of 4-methylumbelliferyl glucuronide and sulfate in the rat
The Journal of pharmacology and experimental therapeutics, 2006-10, Vol.319 (1), p.459
2006
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Hepatobiliary disposition of a drug/metabolite pair: Comprehensive pharmacokinetic modeling in sandwich-cultured rat hepatocytes
The Journal of pharmacology and experimental therapeutics, 2006-08, Vol.318 (2), p.881
2006
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Pharmacokinetics of 5 (and 6)-carboxy-2',7'-dichlorofluorescein and its diacetate promoiety in the liver
The Journal of pharmacology and experimental therapeutics, 2003-02, Vol.304 (2), p.801
2003
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Secretory transport of ranitidine and famotidine across Caco-2 cell monolayers
The Journal of pharmacology and experimental therapeutics, 2002-11, Vol.303 (2), p.574
2002
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