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Physicochemical Evaluation and Developability Assessment of Co-amorphouses of Low Soluble Drugs and Comparison to the Co-crystals

Chemical and Pharmaceutical Bulletin, 2016/12/01, Vol.64(12), pp.1739-1746

2016

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Different Degradation Mechanisms of Inhibitor of Apoptosis Proteins (IAPs) by the Specific and Nongenetic IAP-Dependent Protein Eraser (SNIPER)

Chemical and Pharmaceutical Bulletin, 2019/03/01, Vol.67(3), pp.203-209

2019

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Molecular Modeling, Design, Synthesis, and Biological Activity of 1H-Pyrrolo[2,3-c]pyridine-7-amine Derivatives as Potassium-Competitive Acid Blockers

Chemical and Pharmaceutical Bulletin, 2014/04/01, Vol.62(4), pp.336-342

2014

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Impact of Physicochemical Profiling for Rational Approach on Drug Discovery

Chemical and Pharmaceutical Bulletin, 2013/12/01, Vol.61(12), pp.1228-1238

2013

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Characterization and Quality Control of Pharmaceutical Cocrystals

Chemical and Pharmaceutical Bulletin, 2016/10/01, Vol.64(10), pp.1421-1430

2016

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Discovery of a Novel Series of Pyrazolo[1,5-a]pyrimidine-Based Phosphodiesterase 2A Inhibitors Structurally Different from N-((1S)-1-(3-Fluoro-4-(trifluoromethoxy)phenyl)-2-methoxyethyl)-7-methoxy-2-oxo-2,3-dihydropyrido[2,3-b]pyrazine-4(1H)-carboxamide (TAK-915), for the Treatment of Cognitive Disorders

Chemical and Pharmaceutical Bulletin, 2017/11/01, Vol.65(11), pp.1058-1077

2017

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Discovery of a Potent and Orally Available Acyl-CoA: Cholesterol Acyltransferase Inhibitor as an Anti-atherosclerotic Agent: (4-Phenylcoumarin)acetanilide Derivatives

Chemical and Pharmaceutical Bulletin, 2011/10/01, Vol.59(10), pp.1268-1273

2011

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Screening and Characterization of Hydrate Forms of T-3256336, a Novel Inhibitor of Apoptosis (IAP) Protein Antagonist

Chemical and Pharmaceutical Bulletin, 2015-11, Vol.63 (11), p.858-865

2015

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Synthesis and Biological Activities of 4-Phenyl-5-pyridyl-1,3-thiazole Derivatives as Selective Adenosine A3 Antagonists

Chemical and Pharmaceutical Bulletin, 2008/08/01, Vol.56(8), pp.1126-1137

2008

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A Novel Analytical Method for Pharmaceutical Polymorphs by Terahertz Spectroscopy and the Optimization of Crystal Form at the Discovery Stage

Chemical and Pharmaceutical Bulletin, 2010/01/01, Vol.58(1), pp.76-81

2010

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Characterization of the CYP3A4 Active Site by Homology Modeling

Chemical and Pharmaceutical Bulletin, 2004, Vol.52(7), pp.830-835

2004

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Synthesis and Biological Activities of 4-Phenyl-5-pyridyl-1,3-thiazole Derivatives as p38 MAP Kinase Inhibitors

Chemical and Pharmaceutical Bulletin, 2005, Vol.53(4), pp.410-418

2005

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Formulation Study for Lansoprazole Fast-disintegrating Tablet. III. Design of Rapidly Disintegrating Tablets

Chemical and Pharmaceutical Bulletin, 2003, Vol.51(10), pp.1121-1127

2003

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Optically Active Cyclohexene Derivative as a New Antisepsis Agent: An Efficient Synthesis of Ethyl (6R)-6-[N-(2-Chloro-4-fluorophenyl)sulfamoyl]cyclohex-1-ene-1-carboxylate (TAK-242)

Chemical and Pharmaceutical Bulletin, 2006, Vol.54(1), pp.58-62

2006

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Formulation Study for Lansoprazole Fast-disintegrating Tablet. I. Effect of Compression on Dissolution Behavior

Chemical and Pharmaceutical Bulletin, 2003, Vol.51(8), pp.942-947

2003

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Novel Acyl Coenzyme A: Diacylglycerol Acyltransferase 1 Inhibitors—Synthesis and Biological Activities of N-(Substituted heteroaryl)-4-(substituted phenyl)-4-oxobutanamides

Chemical and Pharmaceutical Bulletin, 2010/05/01, Vol.58(5), pp.673-679

2010

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Characterization of the CYP2C8 Active Site by Homology Modeling

Chemical and Pharmaceutical Bulletin, 2004, Vol.52(7), pp.836-841

2004

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Synthesis of 1-Benzothiepine and 1-Benzazepine Derivatives as Orally Active CCR5 Antagonists

Chemical and Pharmaceutical Bulletin, 2004, Vol.52(2), pp.254-258

2004

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Formulation Study for Lansoprazole Fast-disintegrating Tablet. II. Effect of Triethyl Citrate on the Quality of the Products

Chemical and Pharmaceutical Bulletin, 2003, Vol.51(9), pp.1029-1035

2003

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Orally Active CCR5 Antagonists as Anti-HIV-1 Agents: Synthesis and Biological Activity of 1-Benzothiepine 1,1-Dioxide and 1-Benzazepine Derivatives Containing a Tertiary Amine Moiety

Chemical and Pharmaceutical Bulletin, 2004, Vol.52(5), pp.577-590

2004

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Orally Active CCR5 Antagonists as Anti-HIV-1 Agents 2: Synthesis and Biological Activities of Anilide Derivatives Containing a Pyridine N-Oxide Moiety

Chemical and Pharmaceutical Bulletin, 2004, Vol.52(7), pp.818-829

2004

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CCR5 Antagonists as Anti-HIV-1 Agents. 1. Synthesis and Biological Evaluation of 5-Oxopyrrolidine-3-carboxamide Derivatives

Chemical and Pharmaceutical Bulletin, 2004, Vol.52(1), pp.63-73

2004

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Synthesis and Biological Activity of Novel 5-(ω-Aryloxyalkyl)oxazole Derivatives as Brain-Derived Neurotrophic Factor Inducers

Chemical and Pharmaceutical Bulletin, 2003, Vol.51(5), pp.565-573

2003

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Improvement of Impact Toughness of Sugar-Coated Tablets Manufactured by the Dusting Method

Chemical and Pharmaceutical Bulletin, 2004, Vol.52(3), pp.322-328

2004

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Determination of Ring Conformation in 1-Benzyl-1, 2, 3, 4-tetrahydroisoquinolines and a New Synthesis of the Chiral Compounds

Chemical and Pharmaceutical Bulletin, 1998/03/15, Vol.46(3), pp.430-433

1998

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Physicochemical Evaluation and Developability Assessment of Co-amorphouses of Low Soluble Drugs and Comparison to the Co-crystals

Different Degradation Mechanisms of Inhibitor of Apoptosis Proteins (IAPs) by the Specific and Nongenetic IAP-Dependent Protein Eraser (SNIPER)

Molecular Modeling, Design, Synthesis, and Biological Activity of 1H-Pyrrolo[2,3-c]pyridine-7-amine Derivatives as Potassium-Competitive Acid Blockers

Impact of Physicochemical Profiling for Rational Approach on Drug Discovery

Characterization and Quality Control of Pharmaceutical Cocrystals

Discovery of a Potent and Orally Available Acyl-CoA: Cholesterol Acyltransferase Inhibitor as an Anti-atherosclerotic Agent: (4-Phenylcoumarin)acetanilide Derivatives

Screening and Characterization of Hydrate Forms of T-3256336, a Novel Inhibitor of Apoptosis (IAP) Protein Antagonist

Synthesis and Biological Activities of 4-Phenyl-5-pyridyl-1,3-thiazole Derivatives as Selective Adenosine A3 Antagonists

A Novel Analytical Method for Pharmaceutical Polymorphs by Terahertz Spectroscopy and the Optimization of Crystal Form at the Discovery Stage

Characterization of the CYP3A4 Active Site by Homology Modeling

Synthesis and Biological Activities of 4-Phenyl-5-pyridyl-1,3-thiazole Derivatives as p38 MAP Kinase Inhibitors

Formulation Study for Lansoprazole Fast-disintegrating Tablet. III. Design of Rapidly Disintegrating Tablets

Optically Active Cyclohexene Derivative as a New Antisepsis Agent: An Efficient Synthesis of Ethyl (6R)-6-[N-(2-Chloro-4-fluorophenyl)sulfamoyl]cyclohex-1-ene-1-carboxylate (TAK-242)

Formulation Study for Lansoprazole Fast-disintegrating Tablet. I. Effect of Compression on Dissolution Behavior

Novel Acyl Coenzyme A: Diacylglycerol Acyltransferase 1 Inhibitors—Synthesis and Biological Activities of N-(Substituted heteroaryl)-4-(substituted phenyl)-4-oxobutanamides

Characterization of the CYP2C8 Active Site by Homology Modeling

Synthesis of 1-Benzothiepine and 1-Benzazepine Derivatives as Orally Active CCR5 Antagonists

Formulation Study for Lansoprazole Fast-disintegrating Tablet. II. Effect of Triethyl Citrate on the Quality of the Products

Orally Active CCR5 Antagonists as Anti-HIV-1 Agents: Synthesis and Biological Activity of 1-Benzothiepine 1,1-Dioxide and 1-Benzazepine Derivatives Containing a Tertiary Amine Moiety

Orally Active CCR5 Antagonists as Anti-HIV-1 Agents 2: Synthesis and Biological Activities of Anilide Derivatives Containing a Pyridine N-Oxide Moiety

CCR5 Antagonists as Anti-HIV-1 Agents. 1. Synthesis and Biological Evaluation of 5-Oxopyrrolidine-3-carboxamide Derivatives

Synthesis and Biological Activity of Novel 5-(ω-Aryloxyalkyl)oxazole Derivatives as Brain-Derived Neurotrophic Factor Inducers

Improvement of Impact Toughness of Sugar-Coated Tablets Manufactured by the Dusting Method

Determination of Ring Conformation in 1-Benzyl-1, 2, 3, 4-tetrahydroisoquinolines and a New Synthesis of the Chiral Compounds

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