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Apremilast is a selective PDE4 inhibitor with regulatory effects on innate immunity

Cellular signalling, 2014-09, Vol.26 (9), p.2016-2029

2014

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UCR1C is a novel activator of phosphodiesterase 4 (PDE4) long isoforms and attenuates cardiomyocyte hypertrophy

Cellular signalling, 2015-05, Vol.27 (5), p.908-922

2015

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Phosphodiesterase 4 inhibitors in diabetic nephropathy

Cellular signalling, 2022-02, Vol.90, p.110185-110185, Article 110185

2022

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Phosphodiesterase 4 in inflammatory diseases: Effects of apremilast in psoriatic blood and in dermal myofibroblasts through the PDE4/CD271 complex

Cellular signalling, 2016-07, Vol.28 (7), p.753-763

2016

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Dimerization of cAMP phosphodiesterase-4 (PDE4) in living cells requires interfaces located in both the UCR1 and catalytic unit domains

Cellular signalling, 2015-04, Vol.27 (4), p.756-769

2015

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Identification and characterization of a potent and biologically-active PDE4/7 inhibitor via fission yeast-based assays

Cellular signalling, 2017-12, Vol.40, p.73-80

2017

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Regulation of AMP-activated protein kinase by cAMP in adipocytes: Roles for phosphodiesterases, protein kinase B, protein kinase A, Epac and lipolysis

Cellular signalling, 2009-05, Vol.21 (5), p.760-766

2009

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The RNA-binding protein SERBP1 interacts selectively with the signaling protein RACK1

Cellular signalling, 2017-07, Vol.35, p.256-263

Bolger, Graeme B.

2017

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Specific interactions between Epac1, β-arrestin2 and PDE4D5 regulate β-adrenergic receptor subtype differential effects on cardiac hypertrophic signaling

Cellular signalling, 2013-04, Vol.25 (4), p.970-980

2013

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RACK1 and β-arrestin2 attenuate dimerization of PDE4 cAMP phosphodiesterase PDE4D5

Cellular signalling, 2016-07, Vol.28 (7), p.706-712

Bolger, Graeme B.

2016

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In resting COS1 cells a dominant negative approach shows that specific, anchored PDE4 cAMP phosphodiesterase isoforms gate the activation, by basal cyclic AMP production, of AKAP-tethered protein kinase A type II located in the centrosomal region

Cellular signalling, 2005-09, Vol.17 (9), p.1158-1173

2005

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Uncovering the function of Disrupted in Schizophrenia 1 through interactions with the cAMP phosphodiesterase PDE4: Contributions of the Houslay lab to molecular psychiatry

Cellular signalling, 2016-07, Vol.28 (7), p.749-752

Brandon, Nicholas J.

2016

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PDE4 inhibitor, roflumilast protects cardiomyocytes against NO-induced apoptosis via activation of PKA and Epac dual pathways

Cellular signalling, 2008-05, Vol.20 (5), p.803-814

2008

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Role of PDE3B in insulin-induced glucose uptake, GLUT-4 translocation and lipogenesis in primary rat adipocytes

Cellular signalling, 2006-03, Vol.18 (3), p.382-390

2006

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Ndel1 alters its conformation by sequestering cAMP-specific phosphodiesterase-4D3 (PDE4D3) in a manner that is dynamically regulated through Protein Kinase A (PKA)

Cellular signalling, 2008-12, Vol.20 (12), p.2356-2369

2008

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p62 (SQSTM1) and cyclic AMP phosphodiesterase-4A4 (PDE4A4) locate to a novel, reversible protein aggregate with links to autophagy and proteasome degradation pathways

Cellular signalling, 2010-10, Vol.22 (10), p.1576-1596

2010

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Oxidative stress employs phosphatidyl inositol 3-kinase and ERK signalling pathways to activate cAMP phosphodiesterase-4D3 (PDE4D3) through multi-site phosphorylation at Ser239 and Ser579

Cellular signalling, 2006-11, Vol.18 (11), p.2056-2069

2006

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In cardiac myocytes, cAMP elevation triggers the down-regulation of transcripts and promoter activity for cyclic AMP phosphodiesterase-4A10 (PDE4A10)

Cellular signalling, 2008-11, Vol.20 (11), p.2071-2083

2008

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Cloning and characterization of novel PDE4D isoforms PDE4D6 and PDE4D7

Cellular signalling, 2003-09, Vol.15 (9), p.883-891

2003

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The novel long PDE4A10 cyclic AMP phosphodiesterase shows a pattern of expression within brain that is distinct from the long PDE4A5 and short PDE4A1 isoforms

Cellular signalling, 2001-12, Vol.13 (12), p.911-918

2001

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Identification of inhibitor binding sites of the cAMP-specific phosphodiesterase 4

Cellular signalling, 2001-04, Vol.13 (4), p.287-297

2001

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Genomic Organisation of the Human Cyclic AMP-Specific Phosphodiesterase PDE4C Gene and Its Chromosomal Localisation to 19p13.1, Between RAB3A and JUND

Cellular signalling, 1999-10, Vol.11 (10), p.735-742

1999

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Effect of Pregnancy on PDE4 cAMP-Specific Phosphodiesterase Messenger Ribonucleic Acid Expression in Human Myometrium

Cellular signalling, 1999, Vol.11 (1), p.31-37

1999

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Apremilast is a selective PDE4 inhibitor with regulatory effects on innate immunity

UCR1C is a novel activator of phosphodiesterase 4 (PDE4) long isoforms and attenuates cardiomyocyte hypertrophy

Phosphodiesterase 4 inhibitors in diabetic nephropathy

Phosphodiesterase 4 in inflammatory diseases: Effects of apremilast in psoriatic blood and in dermal myofibroblasts through the PDE4/CD271 complex

Dimerization of cAMP phosphodiesterase-4 (PDE4) in living cells requires interfaces located in both the UCR1 and catalytic unit domains

Identification and characterization of a potent and biologically-active PDE4/7 inhibitor via fission yeast-based assays

Regulation of AMP-activated protein kinase by cAMP in adipocytes: Roles for phosphodiesterases, protein kinase B, protein kinase A, Epac and lipolysis

The RNA-binding protein SERBP1 interacts selectively with the signaling protein RACK1

Specific interactions between Epac1, β-arrestin2 and PDE4D5 regulate β-adrenergic receptor subtype differential effects on cardiac hypertrophic signaling

RACK1 and β-arrestin2 attenuate dimerization of PDE4 cAMP phosphodiesterase PDE4D5

In resting COS1 cells a dominant negative approach shows that specific, anchored PDE4 cAMP phosphodiesterase isoforms gate the activation, by basal cyclic AMP production, of AKAP-tethered protein kinase A type II located in the centrosomal region

Uncovering the function of Disrupted in Schizophrenia 1 through interactions with the cAMP phosphodiesterase PDE4: Contributions of the Houslay lab to molecular psychiatry

PDE4 inhibitor, roflumilast protects cardiomyocytes against NO-induced apoptosis via activation of PKA and Epac dual pathways

Role of PDE3B in insulin-induced glucose uptake, GLUT-4 translocation and lipogenesis in primary rat adipocytes

Ndel1 alters its conformation by sequestering cAMP-specific phosphodiesterase-4D3 (PDE4D3) in a manner that is dynamically regulated through Protein Kinase A (PKA)

p62 (SQSTM1) and cyclic AMP phosphodiesterase-4A4 (PDE4A4) locate to a novel, reversible protein aggregate with links to autophagy and proteasome degradation pathways

Oxidative stress employs phosphatidyl inositol 3-kinase and ERK signalling pathways to activate cAMP phosphodiesterase-4D3 (PDE4D3) through multi-site phosphorylation at Ser239 and Ser579

In cardiac myocytes, cAMP elevation triggers the down-regulation of transcripts and promoter activity for cyclic AMP phosphodiesterase-4A10 (PDE4A10)

Cloning and characterization of novel PDE4D isoforms PDE4D6 and PDE4D7

The novel long PDE4A10 cyclic AMP phosphodiesterase shows a pattern of expression within brain that is distinct from the long PDE4A5 and short PDE4A1 isoforms

Identification of inhibitor binding sites of the cAMP-specific phosphodiesterase 4

Genomic Organisation of the Human Cyclic AMP-Specific Phosphodiesterase PDE4C Gene and Its Chromosomal Localisation to 19p13.1, Between RAB3A and JUND

Effect of Pregnancy on PDE4 cAMP-Specific Phosphodiesterase Messenger Ribonucleic Acid Expression in Human Myometrium

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