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Mutational, Structural, and Kinetic Evidence for a Dissociative Mechanism in the GDP-Mannose Mannosyl Hydrolase Reaction

Biochemistry (Easton), 2005-06, Vol.44 (25), p.8989-8997

2005

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Substrate analog inhibition and active site titration of purified recombinant HIV-1 protease

Biochemistry (Easton), 1990-01, Vol.29 (1), p.264-269

1990

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On the rational design of renin inhibitors: x-ray studies of aspartic proteinases complexed with transition-state analogs

Biochemistry (Easton), 1987-09, Vol.26 (18), p.5585-5590

1987

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Mechanism for slow-binding inhibition of human leukocyte elastase by valine-derived benzoxazinones

Biochemistry (Easton), 1987-06, Vol.26 (13), p.4126-4130

1987

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An investigation of functional similarities between the sarcoplasmic reticulum and platelet calcium-dependent adenosinetriphosphatases with the inhibitors quercetin and calmidazolium

Biochemistry (Easton), 1987-12, Vol.26 (24), p.8024-8030

1987

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Angiogenin activates phospholipase C and elicits a rapid incorporation of fatty acid into cholesterol esters in vascular smooth muscle cells

Biochemistry (Easton), 1990-01, Vol.29 (1), p.228-233

1990

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Purification and characterization of a carboxylesterase from the intestine of the nematode Caenorhabditis elegans

Biochemistry (Easton), 1987-06, Vol.26 (13), p.4101-4107

McGhee, James D.

1987

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Evidence for the presence of five distinct proteolytic components in the pituitary multicatalytic proteinase complex. Properties of two components cleaving bonds on the carboxyl side of branched chain and small neutral amino acids

Biochemistry (Easton), 1993-02, Vol.32 (6), p.1563-1572

1993

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Slow- and tight-binding inhibitors of the 85-kDa human phospholipase A2

Biochemistry (Easton), 1993-06, Vol.32 (23), p.5935-5940

1993

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Inhibitory effect of modified bafilomycins and concanamycins on P- and V-type adenosinetriphosphatases

Biochemistry (Easton), 1993-04, Vol.32 (15), p.3902-3906

1993

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Fluoro ketone inhibitors of hydrolytic enzymes

Biochemistry (Easton), 1985-04, Vol.24 (8), p.1813-1817

1985

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The activity of the tissue inhibitors of metalloproteinases is regulated by C-terminal domain interactions: A kinetic analysis of the inhibition of gelatinase A

Biochemistry (Easton), 1993-04, Vol.32 (16), p.4330-4337

1993

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Irreversible inhibition of serine proteases by peptide derivatives of (.alpha.-aminoalkyl)phosphonate diphenyl esters

Biochemistry (Easton), 1991-01, Vol.30 (2), p.485-493

1991

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Inhibition of human skin fibroblast collagenase, thermolysin, and Pseudomonas aeruginosa elastase by peptide hydroxamic acids

Biochemistry (Easton), 1992-08, Vol.31 (31), p.7152-7154

1992

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Stepwise activation mechanisms of the precursor of matrix metalloproteinase 3 (stromelysin) by proteinases and (4-aminophenyl)mercuric acetate

Biochemistry (Easton), 1990-06, Vol.29 (24), p.5783-5789

1990

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Human and murine cytotoxic T lymphocyte serine proteases: subsite mapping with peptide thioester substrates and inhibition of enzyme activity and cytolysis by isocoumarins

Biochemistry (Easton), 1991-02, Vol.30 (8), p.2217-2227

1991

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Active site labeling of the Yersinia protein tyrosine phosphatase: The determination of the pKa of the active site cysteine and the function of the conserved histidine 402

Biochemistry (Easton), 1993-09, Vol.32 (36), p.9340-9345

1993

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Thrombin is a Na+-activated enzyme

Biochemistry (Easton), 1992-12, Vol.31 (47), p.11721-11730

1992

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Design and characterization of hirulogs: a novel class of bivalent peptide inhibitors of thrombin

Biochemistry (Easton), 1990-07, Vol.29 (30), p.7095-7101

1990

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Inhibition of the chymotrypsin-like activity of the pituitary multicatalytic proteinase complex

Biochemistry (Easton), 1992-10, Vol.31 (39), p.9421-9428

1992

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Kinetics of the pH-induced inactivation of human cathepsin L

Biochemistry (Easton), 1993-01, Vol.32 (1), p.375-380

1993

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Synthesis and evaluation of an inhibitor of carboxypeptidase A with a Ki value in the femtomolar range

Biochemistry (Easton), 1991-08, Vol.30 (33), p.8165-8170

1991

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Human leukocyte and porcine pancreatic elastase: x-ray crystal structures, mechanism, substrate specificity, and mechanism-based inhibitors

Biochemistry (Easton), 1989-03, Vol.28 (5), p.1951-1963

1989

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Multiple magnesium ions in the ribonuclease P reaction mechanism

Biochemistry (Easton), 1993-05, Vol.32 (20), p.5273-5281

1993

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Rat and human pancreatic islet cells contain a calcium ion independent phospholipase A2 activity selective for hydrolysis of arachidonate which is stimulated by adenosine triphosphate and is specifically localized to islet .beta.-cells

Biochemistry (Easton), 1993-01, Vol.32 (1), p.327-336

1993

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Mutational, Structural, and Kinetic Evidence for a Dissociative Mechanism in the GDP-Mannose Mannosyl Hydrolase Reaction

Substrate analog inhibition and active site titration of purified recombinant HIV-1 protease

On the rational design of renin inhibitors: x-ray studies of aspartic proteinases complexed with transition-state analogs

Mechanism for slow-binding inhibition of human leukocyte elastase by valine-derived benzoxazinones

An investigation of functional similarities between the sarcoplasmic reticulum and platelet calcium-dependent adenosinetriphosphatases with the inhibitors quercetin and calmidazolium

Angiogenin activates phospholipase C and elicits a rapid incorporation of fatty acid into cholesterol esters in vascular smooth muscle cells

Purification and characterization of a carboxylesterase from the intestine of the nematode Caenorhabditis elegans

Evidence for the presence of five distinct proteolytic components in the pituitary multicatalytic proteinase complex. Properties of two components cleaving bonds on the carboxyl side of branched chain and small neutral amino acids

Slow- and tight-binding inhibitors of the 85-kDa human phospholipase A2

Inhibitory effect of modified bafilomycins and concanamycins on P- and V-type adenosinetriphosphatases

Fluoro ketone inhibitors of hydrolytic enzymes

The activity of the tissue inhibitors of metalloproteinases is regulated by C-terminal domain interactions: A kinetic analysis of the inhibition of gelatinase A

Irreversible inhibition of serine proteases by peptide derivatives of (.alpha.-aminoalkyl)phosphonate diphenyl esters

Inhibition of human skin fibroblast collagenase, thermolysin, and Pseudomonas aeruginosa elastase by peptide hydroxamic acids

Stepwise activation mechanisms of the precursor of matrix metalloproteinase 3 (stromelysin) by proteinases and (4-aminophenyl)mercuric acetate

Human and murine cytotoxic T lymphocyte serine proteases: subsite mapping with peptide thioester substrates and inhibition of enzyme activity and cytolysis by isocoumarins

Active site labeling of the Yersinia protein tyrosine phosphatase: The determination of the pKa of the active site cysteine and the function of the conserved histidine 402

Thrombin is a Na+-activated enzyme

Design and characterization of hirulogs: a novel class of bivalent peptide inhibitors of thrombin

Inhibition of the chymotrypsin-like activity of the pituitary multicatalytic proteinase complex

Kinetics of the pH-induced inactivation of human cathepsin L

Synthesis and evaluation of an inhibitor of carboxypeptidase A with a Ki value in the femtomolar range

Human leukocyte and porcine pancreatic elastase: x-ray crystal structures, mechanism, substrate specificity, and mechanism-based inhibitors

Multiple magnesium ions in the ribonuclease P reaction mechanism

Rat and human pancreatic islet cells contain a calcium ion independent phospholipase A2 activity selective for hydrolysis of arachidonate which is stimulated by adenosine triphosphate and is specifically localized to islet .beta.-cells

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