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A guide to picking the most selective kinase inhibitor tool compounds for pharmacological validation of drug targets

British journal of pharmacology, 2012-06, Vol.166 (3), p.858-876

2012

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Pharmacological validation of TDO as a target for Parkinson’s disease

The FEBS journal, 2021-07, Vol.288 (14), p.4311-4331

2021

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Optimized Target Residence Time: Type I1/2 Inhibitors for p38α MAP Kinase with Improved Binding Kinetics through Direct Interaction with the R‐Spine

Angewandte Chemie International Edition, 2017-05, Vol.56 (19), p.5363-5367

2017

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A model for signaling specificity of Wnt/Frizzled combinations through co-receptor recruitment

FEBS letters, 2010-09, Vol.584 (18), p.3850-3854

2010

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β-Galactosidase enzyme fragment complementation for the measurement of Wnt/β-catenin signaling

The FASEB journal, 2010-04, Vol.24 (4), p.1205-1217

2010

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Negative and depressive symptoms in suicidal schizophrenics

Acta psychiatrica Scandinavica, 1994-02, Vol.89 (2), p.81-87

1994

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Optimized Target Residence Time: Type I Inhibitors for p38α MAP Kinase with Improved Binding Kinetics through Direct Interaction with the R‐Spine

Angewandte Chemie International Edition, 2017-05, Vol.56 (19), p.5363-5367

2017

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Optimized Target Residence Time: TypeI1 /2 Inhibitors for p38[alpha] MAP Kinase with Improved Binding Kinetics through Direct Interaction with the R-Spine

Angewandte Chemie International Edition, 2017-05, Vol.56 (19), p.5363

International ed. in English, 2017

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Optimierte Bindungsdauer am Zielenzym: Typ-I1 /2 -Inhibitoren der p38[alpha]-MAP-Kinase mit verbesserter Bindungskinetik durch direkte Interaktion mit der R-Spine

Angewandte Chemie, 2017-05, Vol.129 (19), p.5448

2017

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Optimierte Bindungsdauer am Zielenzym: Typ‐I‐Inhibitoren der p38α‐MAP‐Kinase mit verbesserter Bindungskinetik durch direkte Interaktion mit der R‐Spine

Angewandte Chemie, 2017-05, Vol.129 (19), p.5448-5453

2017

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Optimierte Bindungsdauer am Zielenzym: Typ‐I1/2 ‐Inhibitoren der p38α‐MAP‐Kinase mit verbesserter Bindungskinetik durch direkte Interaktion mit der R‐Spine

Angewandte Chemie, 2017-05, Vol.129 (19), p.5448-5453

2017

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Mechanisms of MRP over‐expression in four human lung‐cancer cell lines and analysis of the MRP amplicon

International journal of cancer, 1995-03, Vol.60 (5), p.676-684

1995

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High expression of the multidrug resistance‐associated protein (MRP) in chronic and prolymphocytic leukaemia

British journal of haematology, 1994-10, Vol.88 (2), p.348-356

1994

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The Effect of Water Content on the Thermostability of Solid-State Proteins

Annals of the New York Academy of Sciences, 1996-10, Vol.799 (1), p.108-114

1996

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Microenvironmental Effect of Charged Polymeric Networks on Enzyme Performance

Annals of the New York Academy of Sciences, 1987-06, Vol.501 (1), p.108-112

1987

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Thermal and Chemical Deactivation of Soluble and Stabilized Enzymes

Annals of the New York Academy of Sciences, 1984-12, Vol.434 (1), p.007-019

1984

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Selection and characterization of randomly produced mutants of gene V protein of bacteriophage M13

European journal of biochemistry, 1992-03, Vol.204 (3), p.1003-1014

1992

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Translational regulation of M13 gene II protein by its cognate single‐stranded DNA binding protein

European journal of biochemistry, 1990-04, Vol.189 (1), p.119-124

1990

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Immobilization of Purified Penicillin Acylase in a Polarized Ultrafiltration Membrane Reactor

Annals of the New York Academy of Sciences, 1984-12, Vol.434 (1), p.127-130

1984

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Chiral Self‐Discrimination and Guest Recognition in Helicene‐Based Coordination Cages

Angewandte Chemie International Edition, 2019-04, Vol.58 (17), p.5562-5566

International ed. in English, 2019

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Fire and deforestation dynamics in Amazonia (1973–2014)

Global biogeochemical cycles, 2017-01, Vol.31 (1), p.24-38

2017

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A novel set‐up for the ex vivo analysis of mechanical properties of mouse aortic segments stretched at physiological pressure and frequency

The Journal of physiology, 2016-11, Vol.594 (21), p.6105-6115

2016

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Advancing Scientific Understanding of the Global Methane Budget in Support of the Paris Agreement

Global biogeochemical cycles, 2019-12, Vol.33 (12), p.1475-1512

2019

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Conservation of migratory fishes in the Amazon basin

Aquatic conservation, 2021-05, Vol.31 (5), p.1087-1105

2021

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Species trait diversity sustains multiple dietary nutrients supplied by freshwater fisheries

Ecology letters, 2023-11, Vol.26 (11), p.1887-1897

2023

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A guide to picking the most selective kinase inhibitor tool compounds for pharmacological validation of drug targets

Pharmacological validation of TDO as a target for Parkinson’s disease

Optimized Target Residence Time: Type I1/2 Inhibitors for p38α MAP Kinase with Improved Binding Kinetics through Direct Interaction with the R‐Spine

A model for signaling specificity of Wnt/Frizzled combinations through co-receptor recruitment

β-Galactosidase enzyme fragment complementation for the measurement of Wnt/β-catenin signaling

Negative and depressive symptoms in suicidal schizophrenics

Optimized Target Residence Time: Type I Inhibitors for p38α MAP Kinase with Improved Binding Kinetics through Direct Interaction with the R‐Spine

Optimized Target Residence Time: TypeI1 /2 Inhibitors for p38[alpha] MAP Kinase with Improved Binding Kinetics through Direct Interaction with the R-Spine

Optimierte Bindungsdauer am Zielenzym: Typ-I1 /2 -Inhibitoren der p38[alpha]-MAP-Kinase mit verbesserter Bindungskinetik durch direkte Interaktion mit der R-Spine

Optimierte Bindungsdauer am Zielenzym: Typ‐I‐Inhibitoren der p38α‐MAP‐Kinase mit verbesserter Bindungskinetik durch direkte Interaktion mit der R‐Spine

Optimierte Bindungsdauer am Zielenzym: Typ‐I1/2 ‐Inhibitoren der p38α‐MAP‐Kinase mit verbesserter Bindungskinetik durch direkte Interaktion mit der R‐Spine

Mechanisms of MRP over‐expression in four human lung‐cancer cell lines and analysis of the MRP amplicon

High expression of the multidrug resistance‐associated protein (MRP) in chronic and prolymphocytic leukaemia

The Effect of Water Content on the Thermostability of Solid-State Proteins

Microenvironmental Effect of Charged Polymeric Networks on Enzyme Performance

Thermal and Chemical Deactivation of Soluble and Stabilized Enzymes

Selection and characterization of randomly produced mutants of gene V protein of bacteriophage M13

Translational regulation of M13 gene II protein by its cognate single‐stranded DNA binding protein

Immobilization of Purified Penicillin Acylase in a Polarized Ultrafiltration Membrane Reactor

Chiral Self‐Discrimination and Guest Recognition in Helicene‐Based Coordination Cages

Fire and deforestation dynamics in Amazonia (1973–2014)

A novel set‐up for the ex vivo analysis of mechanical properties of mouse aortic segments stretched at physiological pressure and frequency

Advancing Scientific Understanding of the Global Methane Budget in Support of the Paris Agreement

Conservation of migratory fishes in the Amazon basin

Species trait diversity sustains multiple dietary nutrients supplied by freshwater fisheries

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