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Valproic acid targets HDAC1/2 and HDAC1/PTEN/Akt signalling to inhibit cell proliferation via the induction of autophagy in gastric cancer

The FEBS journal, 2020-05, Vol.287 (10), p.2118-2133

2020

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Valproic acid reverses sorafenib resistance through inhibiting activated Notch/Akt signaling pathway in hepatocellular carcinoma

Fundamental & clinical pharmacology, 2021-08, Vol.35 (4), p.690-699

2021

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Lacosamide effects on placental carriers of essential compounds in comparison with valproate: Studies in perfused human placentas

Epilepsia (Copenhagen), 2022-11, Vol.63 (11), p.2949-2957

2022

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Persistent treatment resistance in genetic generalized epilepsy: A long‐term outcome study in a tertiary epilepsy center

Epilepsia (Copenhagen), 2020-11, Vol.61 (11), p.2452-2460

2020

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Response to the letter to the Editor from Araujo and colleagues on the research article entitled, “Effect of smoking habits and concomitant valproic acid use on relapse in patients with treatment‐resistant schizophrenia receiving clozapine: A 1‐year retrospective cohort study”

Acta psychiatrica Scandinavica, 2024-05, Vol.149 (5), p.436-438

2024

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Association of BDNF risk variant and dorsolateral cortical thickness with long‐term treatment response to valproate in type I bipolar disorder: An exploratory study

American journal of medical genetics. Part B, Neuropsychiatric genetics, 2024-04, Vol.195 (3), p.e32966-n/a

2024

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GABAergic synaptic transmission and cortical oscillation patterns in the primary somatosensory area of a valproic acid rat model of autism spectrum disorder

The European journal of neuroscience, 2023-02, Vol.57 (3), p.527-546

2023

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Antiseizure drug efficacy and tolerability in established and novel drug discovery seizure models in outbred vs inbred mice

Epilepsia (Copenhagen), 2020-09, Vol.61 (9), p.2022-2034

2020

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Efficacy of antiseizure medication in a mouse model of HCN1 developmental and epileptic encephalopathy

Epilepsia (Copenhagen), 2023-01, Vol.64 (1), p.e1-e8

2023

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Transcranial magnetic stimulation as biomarker of excitability in drug development: A randomized, double‐blind, placebo‐controlled, cross‐over study

British journal of clinical pharmacology, 2022-06, Vol.88 (6), p.2926-2937

2022

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Treatment effects of the combination of ceftriaxone and valproic acid on neuronal and behavioural functions in a rat model of epilepsy

Experimental physiology, 2021-08, Vol.106 (8), p.1814-1828

2021

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Valproic acid affects neuronal fate and microglial function via enhancing autophagic flux in mice after traumatic brain injury

Journal of neurochemistry, 2020-08, Vol.154 (3), p.284-300

2020

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Valproic acid increased the efficacy of EGFR TKIs on EGFR/TP53 co‐mutated lung cancers and downregulated mutant‐p53 levels

Molecular carcinogenesis, 2024-02, Vol.63 (2), p.275-285

2024

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Antiepileptic drugs: Impacts on human serum paraoxonase‐1

Journal of biochemical and molecular toxicology, 2017-06, Vol.31 (6), p.n/a

2017

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The antiseizure medication valproate increases hemichannel activity found in brain cells, which could worsen disease outcomes

Journal of neurochemistry, 2024-06, Vol.168 (6), p.1045-1059

2024

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The effects of postnatal erythropoietin and nano‐erythropoietin on behavioral alterations by mediating K‐Cl co‐transporter 2 in the valproic acid‐induced rat model of autism

Developmental psychobiology, 2023-01, Vol.65 (1), p.e22353-n/a

2023

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Breast cancer resistance protein polymorphism ABCG2 c.421C>A (rs2231142) moderates the effect of valproate on lamotrigine trough concentrations in adults with epilepsy

Fundamental & clinical pharmacology, 2024-04, Vol.38 (2), p.351-368

2024

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Valproic acid ameliorates cauda equina injury by suppressing HDAC2‐mediated ferroptosis

CNS neuroscience & therapeutics, 2024-04, Vol.30 (4), p.e14524-n/a

2024

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Valproate treatment induces age‐ and sex‐dependent neuronal activity changes according to a patch clamp study

Developmental neurobiology (Hoboken, N.J.), 2024-01, Vol.84 (1), p.32-43

2024

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Sustained release of sulforaphane by bioactive extracellular vesicles for neuroprotective effect on chick model

Journal of biomedical materials research. Part B, Applied biomaterials, 2022-12, Vol.110 (12), p.2636-2648

2022

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SMA valiant trial: A prospective, double-blind, placebo-controlled trial of valproic acid in ambulatory adults with spinal muscular atrophy

Muscle & nerve, 2014-02, Vol.49 (2), p.187-192

2014

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Xanthotoxin enhances the anticonvulsant potency of levetiracetam and valproate in the 6‐Hz corneal stimulation model in mice

Fundamental & clinical pharmacology, 2022-02, Vol.36 (1), p.133-142

2022

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Differential inflammation responses determine the variable phenotypes of epilepsy induced by GABRG2 mutations

CNS neuroscience & therapeutics, 2024-02, Vol.30 (2), p.e14583-n/a

2024

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Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells

The EMBO journal, 2001-12, Vol.20 (24), p.6969-6978

2001

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The effects of valproic acid on early pregnancy human placentas: Pilot ex vivo analysis in cultured placental villi

Epilepsia (Copenhagen), 2019-05, Vol.60 (5), p.e47-e51

2019

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Valproic acid targets HDAC1/2 and HDAC1/PTEN/Akt signalling to inhibit cell proliferation via the induction of autophagy in gastric cancer

Valproic acid reverses sorafenib resistance through inhibiting activated Notch/Akt signaling pathway in hepatocellular carcinoma

Lacosamide effects on placental carriers of essential compounds in comparison with valproate: Studies in perfused human placentas

Persistent treatment resistance in genetic generalized epilepsy: A long‐term outcome study in a tertiary epilepsy center

Response to the letter to the Editor from Araujo and colleagues on the research article entitled, “Effect of smoking habits and concomitant valproic acid use on relapse in patients with treatment‐resistant schizophrenia receiving clozapine: A 1‐year retrospective cohort study”

Association of BDNF risk variant and dorsolateral cortical thickness with long‐term treatment response to valproate in type I bipolar disorder: An exploratory study

GABAergic synaptic transmission and cortical oscillation patterns in the primary somatosensory area of a valproic acid rat model of autism spectrum disorder

Antiseizure drug efficacy and tolerability in established and novel drug discovery seizure models in outbred vs inbred mice

Efficacy of antiseizure medication in a mouse model of HCN1 developmental and epileptic encephalopathy

Transcranial magnetic stimulation as biomarker of excitability in drug development: A randomized, double‐blind, placebo‐controlled, cross‐over study

Treatment effects of the combination of ceftriaxone and valproic acid on neuronal and behavioural functions in a rat model of epilepsy

Valproic acid affects neuronal fate and microglial function via enhancing autophagic flux in mice after traumatic brain injury

Valproic acid increased the efficacy of EGFR TKIs on EGFR/TP53 co‐mutated lung cancers and downregulated mutant‐p53 levels

Antiepileptic drugs: Impacts on human serum paraoxonase‐1

The antiseizure medication valproate increases hemichannel activity found in brain cells, which could worsen disease outcomes

The effects of postnatal erythropoietin and nano‐erythropoietin on behavioral alterations by mediating K‐Cl co‐transporter 2 in the valproic acid‐induced rat model of autism

Breast cancer resistance protein polymorphism ABCG2 c.421C>A (rs2231142) moderates the effect of valproate on lamotrigine trough concentrations in adults with epilepsy

Valproic acid ameliorates cauda equina injury by suppressing HDAC2‐mediated ferroptosis

Valproate treatment induces age‐ and sex‐dependent neuronal activity changes according to a patch clamp study

Sustained release of sulforaphane by bioactive extracellular vesicles for neuroprotective effect on chick model

SMA valiant trial: A prospective, double-blind, placebo-controlled trial of valproic acid in ambulatory adults with spinal muscular atrophy

Xanthotoxin enhances the anticonvulsant potency of levetiracetam and valproate in the 6‐Hz corneal stimulation model in mice

Differential inflammation responses determine the variable phenotypes of epilepsy induced by GABRG2 mutations

Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells

The effects of valproic acid on early pregnancy human placentas: Pilot ex vivo analysis in cultured placental villi

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