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Valproic acid targets HDAC1/2 and HDAC1/PTEN/Akt signalling to inhibit cell proliferation via the induction of autophagy in gastric cancer

The FEBS journal, 2020-05, Vol.287 (10), p.2118-2133

2020

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Valproic acid reverses sorafenib resistance through inhibiting activated Notch/Akt signaling pathway in hepatocellular carcinoma

Fundamental & clinical pharmacology, 2021-08, Vol.35 (4), p.690-699

2021

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Lacosamide effects on placental carriers of essential compounds in comparison with valproate: Studies in perfused human placentas

Epilepsia (Copenhagen), 2022-11, Vol.63 (11), p.2949-2957

2022

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Persistent treatment resistance in genetic generalized epilepsy: A long‐term outcome study in a tertiary epilepsy center

Epilepsia (Copenhagen), 2020-11, Vol.61 (11), p.2452-2460

2020

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Response to the letter to the Editor from Araujo and colleagues on the research article entitled, “Effect of smoking habits and concomitant valproic acid use on relapse in patients with treatment‐resistant schizophrenia receiving clozapine: A 1‐year retrospective cohort study”

Acta psychiatrica Scandinavica, 2024-05, Vol.149 (5), p.436-438

2024

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Association of BDNF risk variant and dorsolateral cortical thickness with long‐term treatment response to valproate in type I bipolar disorder: An exploratory study

American journal of medical genetics. Part B, Neuropsychiatric genetics, 2024-04, Vol.195 (3), p.e32966-n/a

2024

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GABAergic synaptic transmission and cortical oscillation patterns in the primary somatosensory area of a valproic acid rat model of autism spectrum disorder

The European journal of neuroscience, 2023-02, Vol.57 (3), p.527-546

2023

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Phosphonate Derivatives of Paracetamol and Valproic Acid

ChemMedChem, 2023-02, Vol.18 (4), p.e202200526-n/a

2023

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Antiepileptic drugs: Impacts on human serum paraoxonase‐1

Journal of biochemical and molecular toxicology, 2017-06, Vol.31 (6), p.n/a

2017

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Antiseizure drug efficacy and tolerability in established and novel drug discovery seizure models in outbred vs inbred mice

Epilepsia (Copenhagen), 2020-09, Vol.61 (9), p.2022-2034

2020

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Efficacy of antiseizure medication in a mouse model of HCN1 developmental and epileptic encephalopathy

Epilepsia (Copenhagen), 2023-01, Vol.64 (1), p.e1-e8

2023

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Transcranial magnetic stimulation as biomarker of excitability in drug development: A randomized, double‐blind, placebo‐controlled, cross‐over study

British journal of clinical pharmacology, 2022-06, Vol.88 (6), p.2926-2937

2022

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Treatment effects of the combination of ceftriaxone and valproic acid on neuronal and behavioural functions in a rat model of epilepsy

Experimental physiology, 2021-08, Vol.106 (8), p.1814-1828

2021

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Valproic acid affects neuronal fate and microglial function via enhancing autophagic flux in mice after traumatic brain injury

Journal of neurochemistry, 2020-08, Vol.154 (3), p.284-300

2020

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Valproic acid increased the efficacy of EGFR TKIs on EGFR/TP53 co‐mutated lung cancers and downregulated mutant‐p53 levels

Molecular carcinogenesis, 2024-02, Vol.63 (2), p.275-285

2024

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Genome-wide DNA methylation analysis in an antimigraine-treated preclinical model of cortical spreading depolarization

Cephalalgia, 2023-02, Vol.43 (2), p.3331024221146317-3331024221146317

2023

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Transcriptomic profiling of peripheral blood cells in HPV‐associated carcinoma patients receiving combined valproic acid and avelumab

Molecular oncology, 2024-05, Vol.18 (5), p.1209-1230

2024

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The antiseizure medication valproate increases hemichannel activity found in brain cells, which could worsen disease outcomes

Journal of neurochemistry, 2024-06, Vol.168 (6), p.1045-1059

2024

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Breast cancer resistance protein polymorphism ABCG2 c.421C>A (rs2231142) moderates the effect of valproate on lamotrigine trough concentrations in adults with epilepsy

Fundamental & clinical pharmacology, 2024-04, Vol.38 (2), p.351-368

2024

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Histone Deacetylase Inhibition with Valproic Acid Downregulates Osteocalcin Gene Expression in Human Dental Pulp Stem Cells and Osteoblasts: Evidence for HDAC2 Involvement

Stem cells (Dayton, Ohio), 2014-01, Vol.32 (1), p.279-289

2014

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Switching the Mode of Cell Death between Apoptosis and Autophagy by Histone Deacetylase 6 Inhibition Levels

ChemMedChem, 2023-03, Vol.18 (5), p.e202200614-n/a

2023

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Inhibitory Effect of Valproic Acid on Cytochrome P450 2C9 Activity in Epilepsy Patients

Basic & clinical pharmacology & toxicology, 2007-06, Vol.100 (6), p.383-386

2007

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The effects of postnatal erythropoietin and nano‐erythropoietin on behavioral alterations by mediating K‐Cl co‐transporter 2 in the valproic acid‐induced rat model of autism

Developmental psychobiology, 2023-01, Vol.65 (1), p.e22353-n/a

2023

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Valproic acid ameliorates cauda equina injury by suppressing HDAC2‐mediated ferroptosis

CNS neuroscience & therapeutics, 2024-04, Vol.30 (4), p.e14524-n/a

2024

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Glia and epilepsy: Experimental investigation of antiepileptic drugs in an astroglia/microglia co‐culture model of inflammation

Epilepsia (Copenhagen), 2014-01, Vol.55 (1), p.184-192

2014

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Valproic acid targets HDAC1/2 and HDAC1/PTEN/Akt signalling to inhibit cell proliferation via the induction of autophagy in gastric cancer

Valproic acid reverses sorafenib resistance through inhibiting activated Notch/Akt signaling pathway in hepatocellular carcinoma

Lacosamide effects on placental carriers of essential compounds in comparison with valproate: Studies in perfused human placentas

Persistent treatment resistance in genetic generalized epilepsy: A long‐term outcome study in a tertiary epilepsy center

Response to the letter to the Editor from Araujo and colleagues on the research article entitled, “Effect of smoking habits and concomitant valproic acid use on relapse in patients with treatment‐resistant schizophrenia receiving clozapine: A 1‐year retrospective cohort study”

Association of BDNF risk variant and dorsolateral cortical thickness with long‐term treatment response to valproate in type I bipolar disorder: An exploratory study

GABAergic synaptic transmission and cortical oscillation patterns in the primary somatosensory area of a valproic acid rat model of autism spectrum disorder

Phosphonate Derivatives of Paracetamol and Valproic Acid

Antiepileptic drugs: Impacts on human serum paraoxonase‐1

Antiseizure drug efficacy and tolerability in established and novel drug discovery seizure models in outbred vs inbred mice

Efficacy of antiseizure medication in a mouse model of HCN1 developmental and epileptic encephalopathy

Transcranial magnetic stimulation as biomarker of excitability in drug development: A randomized, double‐blind, placebo‐controlled, cross‐over study

Treatment effects of the combination of ceftriaxone and valproic acid on neuronal and behavioural functions in a rat model of epilepsy

Valproic acid affects neuronal fate and microglial function via enhancing autophagic flux in mice after traumatic brain injury

Valproic acid increased the efficacy of EGFR TKIs on EGFR/TP53 co‐mutated lung cancers and downregulated mutant‐p53 levels

Genome-wide DNA methylation analysis in an antimigraine-treated preclinical model of cortical spreading depolarization

Transcriptomic profiling of peripheral blood cells in HPV‐associated carcinoma patients receiving combined valproic acid and avelumab

The antiseizure medication valproate increases hemichannel activity found in brain cells, which could worsen disease outcomes

Breast cancer resistance protein polymorphism ABCG2 c.421C>A (rs2231142) moderates the effect of valproate on lamotrigine trough concentrations in adults with epilepsy

Histone Deacetylase Inhibition with Valproic Acid Downregulates Osteocalcin Gene Expression in Human Dental Pulp Stem Cells and Osteoblasts: Evidence for HDAC2 Involvement

Switching the Mode of Cell Death between Apoptosis and Autophagy by Histone Deacetylase 6 Inhibition Levels

Inhibitory Effect of Valproic Acid on Cytochrome P450 2C9 Activity in Epilepsy Patients

The effects of postnatal erythropoietin and nano‐erythropoietin on behavioral alterations by mediating K‐Cl co‐transporter 2 in the valproic acid‐induced rat model of autism

Valproic acid ameliorates cauda equina injury by suppressing HDAC2‐mediated ferroptosis

Glia and epilepsy: Experimental investigation of antiepileptic drugs in an astroglia/microglia co‐culture model of inflammation

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