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Sacituzumab govitecan (IMMU‐132), an anti‐Trop‐2‐SN‐38 antibody‐drug conjugate for the treatment of diverse epithelial cancers: Safety and pharmacokinetics

Cancer, 2017-10, Vol.123 (19), p.3843-3854

2017

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Drug Delivery with PEGylated MoS2 Nano-sheets for Combined Photothermal and Chemotherapy of Cancer

Advanced materials (Weinheim), 2014-06, Vol.26 (21), p.3433-3440

2014

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An Activatable Theranostic for Targeted Cancer Therapy and Imaging

Angewandte Chemie (International ed.), 2014-04, Vol.53 (17), p.4469-4474

International ed. in English, 2014

Volltextzugriff (PDF)

Hydrophobic Anticancer Drug Delivery by a 980 nm Laser-Driven Photothermal Vehicle for Efficient Synergistic Therapy of Cancer Cells In Vivo

Advanced materials (Weinheim), 2013-08, Vol.25 (32), p.4452-4458

2013

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A validated HPLC‐MS/MS method for determination of simmitecan and its metabolite chimmitecan in human plasma and its application to a pharmacokinetic study in Chinese patients with advanced solid tumor

Journal of separation science, 2021-11, Vol.44 (21), p.3959-3966

2021

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Fasting protects against the side effects of irinotecan treatment but does not affect anti‐tumour activity in mice

British journal of pharmacology, 2016-03, Vol.173 (5), p.804-814

2016

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Genotype‐directed, dose‐finding study of irinotecan in cancer patients with UGT1A128 and/or UGT1A16 polymorphisms

Cancer science, 2011-10, Vol.102 (10), p.1868-1873

2011

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Pharmacogenetics and pharmacogenomics of anticancer agents

CA: a cancer journal for clinicians, 2009-01, Vol.59 (1), p.42-55

2009

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Human Neural Stem Cell Tropism to Metastatic Breast Cancer

Stem cells (Dayton, Ohio), 2012-02, Vol.30 (2), p.314-325

2012

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The Inhibitory Effect of Ciprofloxacin on the β‐Glucuronidase‐mediated Deconjugation of the Irinotecan Metabolite SN‐38‐G

Basic & clinical pharmacology & toxicology, 2016-05, Vol.118 (5), p.333-337

2016

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Irinotecan-induced Diarrhea: Functional Significance of the Polymorphic ABCC2 Transporter Protein

Clinical pharmacology and therapeutics, 2007-01, Vol.81 (1), p.42-49

2007

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Arginine‐Modified Nanostructured Lipid Carriers with Charge‐Reversal and pH‐Sensitive Membranolytic Properties for Anticancer Drug Delivery

Advanced healthcare materials, 2017-04, Vol.6 (8), p.np-n/a

2017

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Irinotecan and its active metabolite, SN-38: review of bioanalytical methods and recent update from clinical pharmacology perspectives

Biomedical chromatography, 2010-01, Vol.24 (1), p.104-123

2010

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Pharmacokinetic modeling of the blood‐stable camptothecin analog AR‐67 in two different formulations

Biopharmaceutics & drug disposition, 2019-09, Vol.40 (8), p.265-275

2019

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Safety, pharmacokinetics, and activity of EZN‐2208, a novel conjugate of polyethylene glycol and SN38, in patients with advanced malignancies

Cancer, 2012-12, Vol.118 (24), p.6144-6151

2012

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Clinical pharmacokinetics of irinotecan and its metabolites in relation with diarrhea

Clinical pharmacology and therapeutics, 2002-09, Vol.72 (3), p.265-275

2002

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Synthesis, antitumor activity and pharmacokinetic study of 10‐propionyloxy camptothecin in rats

Biomedical chromatography, 2018-11, Vol.32 (11), p.e4336-n/a

2018

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Associations of ABCB1, ABCC2, and ABCG2 polymorphisms with irinotecan‐pharmacokinetics and clinical outcome in patients with advanced non‐small cell lung cancer

Cancer, 2007-07, Vol.110 (1), p.138-147

2007

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Determination of irinotecan, SN‐38 and SN‐38 glucuronide using HPLC/MS/MS: Application in a clinical pharmacokinetic and personalized medicine in colorectal cancer patients

Journal of clinical laboratory analysis, 2018-01, Vol.32 (1), p.n/a

2018

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Integrative population pharmacokinetic and pharmacodynamic dose finding approach of the new camptothecin compound namitecan (ST1968)

British journal of clinical pharmacology, 2015-07, Vol.80 (1), p.128-138

2015

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Pharmacokinetics and Tissue Distribution of Folate-Decorated Human Serum Albumin Loaded With Nano-Hydroxycamptothecin for Tumor Targeting

Journal of pharmaceutical sciences, 2016-06, Vol.105 (6), p.1874-1880

2016

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Efficient Intracellular Delivery of Camptothecin by Silica/Titania Hollow Nanoparticles

Chemistry : a European journal, 2012-04, Vol.18 (16), p.4902-4908

2012

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Phase 1 evaluation of EZN-2208, a polyethylene glycol conjugate of SN38, in children adolescents and young adults with relapsed or refractory solid tumors

Pediatric blood & cancer, 2014-10, Vol.61 (10), p.1792-1797

2014

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Diflomotecan pharmacokinetics in relation to ABCG2 421C>A genotype

Clinical pharmacology and therapeutics, 2004-07, Vol.76 (1), p.38-44

2004

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Administration of Cetuximab Every 2 Weeks in the Treatment of Metastatic Colorectal Cancer: An Effective, More Convenient Alternative to Weekly Administration?

The oncologist (Dayton, Ohio), 2008-02, Vol.13 (2), p.113-119

2008

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Sacituzumab govitecan (IMMU‐132), an anti‐Trop‐2‐SN‐38 antibody‐drug conjugate for the treatment of diverse epithelial cancers: Safety and pharmacokinetics

Drug Delivery with PEGylated MoS2 Nano-sheets for Combined Photothermal and Chemotherapy of Cancer

An Activatable Theranostic for Targeted Cancer Therapy and Imaging

Hydrophobic Anticancer Drug Delivery by a 980 nm Laser-Driven Photothermal Vehicle for Efficient Synergistic Therapy of Cancer Cells In Vivo

A validated HPLC‐MS/MS method for determination of simmitecan and its metabolite chimmitecan in human plasma and its application to a pharmacokinetic study in Chinese patients with advanced solid tumor

Fasting protects against the side effects of irinotecan treatment but does not affect anti‐tumour activity in mice

Genotype‐directed, dose‐finding study of irinotecan in cancer patients with UGT1A128 and/or UGT1A16 polymorphisms

Pharmacogenetics and pharmacogenomics of anticancer agents

Human Neural Stem Cell Tropism to Metastatic Breast Cancer

The Inhibitory Effect of Ciprofloxacin on the β‐Glucuronidase‐mediated Deconjugation of the Irinotecan Metabolite SN‐38‐G

Irinotecan-induced Diarrhea: Functional Significance of the Polymorphic ABCC2 Transporter Protein

Arginine‐Modified Nanostructured Lipid Carriers with Charge‐Reversal and pH‐Sensitive Membranolytic Properties for Anticancer Drug Delivery

Irinotecan and its active metabolite, SN-38: review of bioanalytical methods and recent update from clinical pharmacology perspectives

Pharmacokinetic modeling of the blood‐stable camptothecin analog AR‐67 in two different formulations

Safety, pharmacokinetics, and activity of EZN‐2208, a novel conjugate of polyethylene glycol and SN38, in patients with advanced malignancies

Clinical pharmacokinetics of irinotecan and its metabolites in relation with diarrhea

Synthesis, antitumor activity and pharmacokinetic study of 10‐propionyloxy camptothecin in rats

Associations of ABCB1, ABCC2, and ABCG2 polymorphisms with irinotecan‐pharmacokinetics and clinical outcome in patients with advanced non‐small cell lung cancer

Determination of irinotecan, SN‐38 and SN‐38 glucuronide using HPLC/MS/MS: Application in a clinical pharmacokinetic and personalized medicine in colorectal cancer patients

Integrative population pharmacokinetic and pharmacodynamic dose finding approach of the new camptothecin compound namitecan (ST1968)

Pharmacokinetics and Tissue Distribution of Folate-Decorated Human Serum Albumin Loaded With Nano-Hydroxycamptothecin for Tumor Targeting

Efficient Intracellular Delivery of Camptothecin by Silica/Titania Hollow Nanoparticles

Phase 1 evaluation of EZN-2208, a polyethylene glycol conjugate of SN38, in children adolescents and young adults with relapsed or refractory solid tumors

Diflomotecan pharmacokinetics in relation to ABCG2 421C>A genotype

Administration of Cetuximab Every 2 Weeks in the Treatment of Metastatic Colorectal Cancer: An Effective, More Convenient Alternative to Weekly Administration?

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