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Metabolite profiling and identification of enzymes responsible for the metabolism of mitragynine, the major alkaloid of Mitragyna speciosa (kratom)

Xenobiotica, 2019-11, Vol.49 (11), p.1279-1288

2019

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A comprehensive assay for nine major cytochrome P450 enzymes activities with 16 probe reactions on human liver microsomes by a single LC/MS/MS run to support reliable in vitro inhibitory drug-drug interaction evaluation

Xenobiotica, 2015-11, Vol.45 (11), p.961-977

2015

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The role of drug metabolizing enzymes in clearance

Expert opinion on drug metabolism & toxicology, 2014-03, Vol.10 (3), p.379-393

Di, Li

2014

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In vitro characterization of glycyrol metabolites in human liver microsomes using HR-resolution MS spectrometer coupled with tandem mass spectrometry

Xenobiotica, 2020-04, Vol.50 (4), p.380-388

2020

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Study on the metabolism of natural sesquiterpene lactones in human liver microsomes using LC-Q-TOF-MS/MS

Natural product research, 2024-06, Vol.38 (11), p.1855-1863

2024

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Interindividual variability in hepatic drug glucuronidation: studies into the role of age, sex, enzyme inducers, and genetic polymorphism using the human liver bank as a model system

Drug metabolism reviews, 2010-02, Vol.42 (1), p.209-224

Court, Michael H.

2010

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Rehmannioside A inhibits the activity of CYP3A4, 2C9 and 2D6 in vitro

Xenobiotica, 2024-04, Vol.54 (4), p.195-200

2024

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Drug-drug interaction between danshensu and irbesartan and its potential mechanism

Xenobiotica, 2024-04, Vol.54 (4), p.211-216

2024

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Untargeted metabolomics-assisted comparative cytochrome P450-dependent metabolism of fenbendazole in human and dog liver microsomes

Xenobiotica, 2022-11, Vol.52 (9-11), p.986-996

2022

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Age-related changes of hepatic clearances of cytochrome P450 probes, midazolam and R-/S-warfarin in combination with caffeine, omeprazole and metoprolol in cynomolgus monkeys using in vitro-in vivo correlation

Xenobiotica, 2015-04, Vol.45 (4), p.312-321

2015

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Protection against Fatty Liver but Normal Adipogenesis in Mice Lacking Adipose Differentiation-Related Protein

Molecular and Cellular Biology, 2006-02, Vol.26 (3), p.1063-1076

2006

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Effect of tubeimoside I on the activity of cytochrome P450 enzymes in human liver microsomes

Xenobiotica, 2024-02, Vol.54 (2), p.57-63

2024

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In vitro glucuronidation of bisphenol A in liver and intestinal microsomes: interspecies differences in humans and laboratory animals

Drug and chemical toxicology (New York, N.Y. 1978), 2022-07, Vol.45 (4), p.1565-1569

2022

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Non-specific binding of compounds in in vitro metabolism assays: a comparison of microsomal and hepatocyte binding in different species and an assessment of the accuracy of prediction models

Xenobiotica, 2022-08, Vol.52 (8), p.943-956

2022

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Effects of ticagrelor on the pharmacokinetics of rivaroxaban in rats

Pharmaceutical biology, 2020-01, Vol.58 (1), p.630-635

2020

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Identification of novel glutathione conjugates of terbinafine in liver microsomes and hepatocytes across species

Xenobiotica, 2019-12, Vol.49 (12), p.1403-1413

2019

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Pharmacogenomics of human liver cytochrome P450 oxidoreductase: multifactorial analysis and impact on microsomal drug oxidation

Pharmacogenomics, 2009-04, Vol.10 (4), p.579-599

2009

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In vitro inhibitory effects of dihydromyricetin on human liver cytochrome P450 enzymes

Pharmaceutical biology, 2017, Vol.55 (1), p.1868-1874

2017

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Inhibitory effect of resveratrol on the pharmacokinetic of ibrutinib by UPLC-MS/MS

Drug development and industrial pharmacy, 2019-01, Vol.45 (1), p.27-31

2019

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In vitro study on the effect of ophiopogonin D on the activity of cytochrome P450 enzymes

Xenobiotica, 2021-04, Vol.51 (3), p.262-267

2021

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The effects of triptolide on the pharmacokinetics of sorafenib in rats and its potential mechanism

Pharmaceutical biology, 2017, Vol.55 (1), p.1863-1867

2017

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Optimal pH 8.5 to 9 for the hydrolysis of vixotrigine and other basic substrates of carboxylesterase-1 in human liver microsomes

Xenobiotica, 2022-02, Vol.52 (2), p.105-112

2022

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Identification and analysis of the reactive metabolites related to the hepatotoxicity of safrole

Xenobiotica, 2018-11, Vol.48 (11), p.1164-1172

2018

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Impact of CYP2B6 polymorphism on hepatic efavirenz metabolism in vitro

Pharmacogenomics, 2007-06, Vol.8 (6), p.547-558

2007

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Metabolic map of osthole and its effect on lipids

Xenobiotica, 2018-03, Vol.48 (3), p.285-299

2018

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Metabolite profiling and identification of enzymes responsible for the metabolism of mitragynine, the major alkaloid of Mitragyna speciosa (kratom)

A comprehensive assay for nine major cytochrome P450 enzymes activities with 16 probe reactions on human liver microsomes by a single LC/MS/MS run to support reliable in vitro inhibitory drug-drug interaction evaluation

The role of drug metabolizing enzymes in clearance

In vitro characterization of glycyrol metabolites in human liver microsomes using HR-resolution MS spectrometer coupled with tandem mass spectrometry

Study on the metabolism of natural sesquiterpene lactones in human liver microsomes using LC-Q-TOF-MS/MS

Interindividual variability in hepatic drug glucuronidation: studies into the role of age, sex, enzyme inducers, and genetic polymorphism using the human liver bank as a model system

Rehmannioside A inhibits the activity of CYP3A4, 2C9 and 2D6 in vitro

Drug-drug interaction between danshensu and irbesartan and its potential mechanism

Untargeted metabolomics-assisted comparative cytochrome P450-dependent metabolism of fenbendazole in human and dog liver microsomes

Age-related changes of hepatic clearances of cytochrome P450 probes, midazolam and R-/S-warfarin in combination with caffeine, omeprazole and metoprolol in cynomolgus monkeys using in vitro-in vivo correlation

Protection against Fatty Liver but Normal Adipogenesis in Mice Lacking Adipose Differentiation-Related Protein

Effect of tubeimoside I on the activity of cytochrome P450 enzymes in human liver microsomes

In vitro glucuronidation of bisphenol A in liver and intestinal microsomes: interspecies differences in humans and laboratory animals

Non-specific binding of compounds in in vitro metabolism assays: a comparison of microsomal and hepatocyte binding in different species and an assessment of the accuracy of prediction models

Effects of ticagrelor on the pharmacokinetics of rivaroxaban in rats

Identification of novel glutathione conjugates of terbinafine in liver microsomes and hepatocytes across species

Pharmacogenomics of human liver cytochrome P450 oxidoreductase: multifactorial analysis and impact on microsomal drug oxidation

In vitro inhibitory effects of dihydromyricetin on human liver cytochrome P450 enzymes

Inhibitory effect of resveratrol on the pharmacokinetic of ibrutinib by UPLC-MS/MS

In vitro study on the effect of ophiopogonin D on the activity of cytochrome P450 enzymes

The effects of triptolide on the pharmacokinetics of sorafenib in rats and its potential mechanism

Optimal pH 8.5 to 9 for the hydrolysis of vixotrigine and other basic substrates of carboxylesterase-1 in human liver microsomes

Identification and analysis of the reactive metabolites related to the hepatotoxicity of safrole

Impact of CYP2B6 polymorphism on hepatic efavirenz metabolism in vitro

Metabolic map of osthole and its effect on lipids

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