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First-in-human phase 1/2a trial of CRLX101, a cyclodextrin-containing polymer-camptothecin nanopharmaceutical in patients with advanced solid tumor malignancies

Investigational new drugs, 2013-08, Vol.31 (4), p.986-1000

2013

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Population Pharmacokinetics of Sacituzumab Govitecan in Patients with Metastatic Triple-Negative Breast Cancer and Other Solid Tumors

Clinical pharmacokinetics, 2024-05, Vol.63 (5), p.669-681

2024

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Fecal SN-38 Content as a Surrogate Predictor of Intestinal SN-38 Exposure and Associated Irinotecan-induced Severe Delayed-Onset Diarrhea by a Novel Use of the Spectrofluorimetric Method

Pharmaceutical research, 2024-09, Vol.41 (9), p.1855-1867

2024

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Phase I study of nanoliposomal irinotecan (PEP02) in advanced solid tumor patients

Cancer chemotherapy and pharmacology, 2015-03, Vol.75 (3), p.579-586

2015

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Population pharmacokinetic analysis of nanoparticle-bound and free camptothecin after administration of NLG207 in adults with advanced solid tumors

Cancer chemotherapy and pharmacology, 2020-10, Vol.86 (4), p.475-486

2020

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A Phase I study of olaparib and irinotecan in patients with colorectal cancer: Canadian Cancer Trials Group IND 187

Investigational new drugs, 2016-08, Vol.34 (4), p.450-457

2016

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Liposomal Irinotecan: A Review in Metastatic Pancreatic Adenocarcinoma

Drugs (New York, N.Y.), 2017-05, Vol.77 (7), p.785-792

2017

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Distribution and quantification of irinotecan and its active metabolite SN-38 in colon cancer murine model systems using MALDI MSI

Analytical and bioanalytical chemistry, 2015-03, Vol.407 (8), p.2107-2116

2015

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Elucidation of Carboxylesterase Mediated Pharmacokinetic Interactions between Irinotecan and Oroxylin A in Rats via Physiologically Based Pharmacokinetic Modeling

Pharmaceutical research, 2023-11, Vol.40 (11), p.2627-2638

2023

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Simulation and computational study of graphene oxide nano-carriers, absorption, and release of the anticancer drug of camptothecin

Journal of molecular modeling, 2021-09, Vol.27 (9), p.251-251, Article 251

2021

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Polypeptide-based Micelles for Delivery of Irinotecan: Physicochemical and In vivo Characterization

Pharmaceutical research, 2015-06, Vol.32 (6), p.1947-1956

2015

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A phase 1 trial of intravenous liposomal irinotecan in patients with recurrent high-grade glioma

Cancer chemotherapy and pharmacology, 2017-03, Vol.79 (3), p.603-610

2017

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A phase I dose-escalation study of PEP02 (irinotecan liposome injection) in combination with 5-fluorouracil and leucovorin in advanced solid tumors

BMC cancer, 2016-11, Vol.16 (1), p.907, Article 907

2016

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Pharmacokinetics of Irinotecan, Oxaliplatin and 5-Fluorouracil During Hepatic Artery Chronomodulated Infusion: A Translational European OPTILIV Study

Clinical pharmacokinetics, 2017-02, Vol.56 (2), p.165-177

2017

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The pharmacokinetic interaction between irinotecan and sunitinib

Cancer chemotherapy and pharmacology, 2020-02, Vol.85 (2), p.443-448

2020

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Population pharmacokinetic analysis of AR-67, a lactone stable camptothecin analogue, in cancer patients with solid tumors

Investigational new drugs, 2019-12, Vol.37 (6), p.1218-1230

2019

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Virtual Clinical Studies to Examine the Probability Distribution of the AUC at Target Tissues Using Physiologically-Based Pharmacokinetic Modeling: Application to Analyses of the Effect of Genetic Polymorphism of Enzymes and Transporters on Irinotecan Induced Side Effects

Pharmaceutical research, 2017-08, Vol.34 (8), p.1584-1600

2017

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A phase I dose escalation study of NK012, an SN-38 incorporating macromolecular polymeric micelle

Cancer chemotherapy and pharmacology, 2016-05, Vol.77 (5), p.1079-1086

2016

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A phase II study of UCN-01 in combination with irinotecan in patients with metastatic triple negative breast cancer

Breast cancer research and treatment, 2013-01, Vol.137 (2), p.483-492

2013

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DC BeadM1™: towards an optimal transcatheter hepatic tumour therapy

Journal of materials science. Materials in medicine, 2016-01, Vol.27 (1), p.13-12, Article 13

2016

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Phase I dose-escalation study of EZN-2208 (PEG-SN38), a novel conjugate of poly(ethylene) glycol and SN38, administered weekly in patients with advanced cancer

Cancer chemotherapy and pharmacology, 2013-06, Vol.71 (6), p.1499-1506

2013

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Effect of Single Nucleotide Polymorphisms in the Xenobiotic-sensing Receptors NR1I2 and NR1I3 on the Pharmacokinetics and Toxicity of Irinotecan in Colorectal Cancer Patients

Clinical pharmacokinetics, 2016-09, Vol.55 (9), p.1145-1157

2016

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Irinotecan Drug-Eluting Beads in the Treatment of Chemo-Naive Unresectable Colorectal Liver Metastasis with Concomitant Systemic Fluorouracil and Oxaliplatin: Results of Pharmacokinetics and Phase I Trial

Journal of gastrointestinal surgery, 2012-08, Vol.16 (8), p.1531-1538

2012

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Irinotecan and temozolomide brain distribution: a focus on ABCB1

Cancer chemotherapy and pharmacology, 2014-07, Vol.74 (1), p.185-193

2014

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Safety, efficacy, and pharmacokinetics of navitoclax (ABT-263) in combination with irinotecan: results of an open-label, phase 1 study

Cancer chemotherapy and pharmacology, 2015-11, Vol.76 (5), p.1041-1049

2015

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First-in-human phase 1/2a trial of CRLX101, a cyclodextrin-containing polymer-camptothecin nanopharmaceutical in patients with advanced solid tumor malignancies

Population Pharmacokinetics of Sacituzumab Govitecan in Patients with Metastatic Triple-Negative Breast Cancer and Other Solid Tumors

Fecal SN-38 Content as a Surrogate Predictor of Intestinal SN-38 Exposure and Associated Irinotecan-induced Severe Delayed-Onset Diarrhea by a Novel Use of the Spectrofluorimetric Method

Phase I study of nanoliposomal irinotecan (PEP02) in advanced solid tumor patients

Population pharmacokinetic analysis of nanoparticle-bound and free camptothecin after administration of NLG207 in adults with advanced solid tumors

A Phase I study of olaparib and irinotecan in patients with colorectal cancer: Canadian Cancer Trials Group IND 187

Liposomal Irinotecan: A Review in Metastatic Pancreatic Adenocarcinoma

Distribution and quantification of irinotecan and its active metabolite SN-38 in colon cancer murine model systems using MALDI MSI

Elucidation of Carboxylesterase Mediated Pharmacokinetic Interactions between Irinotecan and Oroxylin A in Rats via Physiologically Based Pharmacokinetic Modeling

Simulation and computational study of graphene oxide nano-carriers, absorption, and release of the anticancer drug of camptothecin

Polypeptide-based Micelles for Delivery of Irinotecan: Physicochemical and In vivo Characterization

A phase 1 trial of intravenous liposomal irinotecan in patients with recurrent high-grade glioma

A phase I dose-escalation study of PEP02 (irinotecan liposome injection) in combination with 5-fluorouracil and leucovorin in advanced solid tumors

Pharmacokinetics of Irinotecan, Oxaliplatin and 5-Fluorouracil During Hepatic Artery Chronomodulated Infusion: A Translational European OPTILIV Study

The pharmacokinetic interaction between irinotecan and sunitinib

Population pharmacokinetic analysis of AR-67, a lactone stable camptothecin analogue, in cancer patients with solid tumors

Virtual Clinical Studies to Examine the Probability Distribution of the AUC at Target Tissues Using Physiologically-Based Pharmacokinetic Modeling: Application to Analyses of the Effect of Genetic Polymorphism of Enzymes and Transporters on Irinotecan Induced Side Effects

A phase I dose escalation study of NK012, an SN-38 incorporating macromolecular polymeric micelle

A phase II study of UCN-01 in combination with irinotecan in patients with metastatic triple negative breast cancer

DC BeadM1™: towards an optimal transcatheter hepatic tumour therapy

Phase I dose-escalation study of EZN-2208 (PEG-SN38), a novel conjugate of poly(ethylene) glycol and SN38, administered weekly in patients with advanced cancer

Effect of Single Nucleotide Polymorphisms in the Xenobiotic-sensing Receptors NR1I2 and NR1I3 on the Pharmacokinetics and Toxicity of Irinotecan in Colorectal Cancer Patients

Irinotecan Drug-Eluting Beads in the Treatment of Chemo-Naive Unresectable Colorectal Liver Metastasis with Concomitant Systemic Fluorouracil and Oxaliplatin: Results of Pharmacokinetics and Phase I Trial

Irinotecan and temozolomide brain distribution: a focus on ABCB1

Safety, efficacy, and pharmacokinetics of navitoclax (ABT-263) in combination with irinotecan: results of an open-label, phase 1 study

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