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The challenges of clinical trials in fragile X syndrome

Psychopharmacology, 2014-03, Vol.231 (6), p.1237-1250

2014

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Genetic models of cleavage-reduced and soluble TREM2 reveal distinct effects on myelination and microglia function in the cuprizone model

Journal of neuroinflammation, 2023-02, Vol.20 (1), p.29-29, Article 29

2023

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Fractalkine shedding is mediated by p38 and the ADAM10 protease under pro-inflammatory conditions in human astrocytes

Journal of neuroinflammation, 2016-08, Vol.13 (1), p.189-189, Article 189

2016

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Reciprocal changes in DNA methylation and hydroxymethylation and a broad repressive epigenetic switch characterize FMR1 transcriptional silencing in fragile X syndrome

Clinical epigenetics, 2016-02, Vol.8 (15), p.15-15, Article 15

2016

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The mGluR5 antagonist AFQ056 does not affect methylation and transcription of the mutant FMR1 gene in vitro

BMC medical genetics, 2012-03, Vol.13 (1), p.13-13, Article 13

2012

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Radiation dosimetry and biodistribution of 11C-ABP688 measured in healthy volunteers

European journal of nuclear medicine and molecular imaging, 2008-04, Vol.35 (4), p.766-770

2008

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Fragile X syndrome: a preclinical review on metabotropic glutamate receptor 5 (mGluR5) antagonists and drug development

Psychopharmacology, 2014-03, Vol.231 (6), p.1217-1226

2014

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Rescue of dendritic spine phenotype in Fmr1 KO mice with the mGluR5 antagonist AFQ056/Mavoglurant

Psychopharmacology, 2014-03, Vol.231 (6), p.1227-1235

2014

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Mavoglurant Augmentation in OCD Patients Resistant to Selective Serotonin Reuptake Inhibitors: A Proof-of-Concept, Randomized, Placebo-Controlled, Phase 2 Study

Advances in therapy, 2017-02, Vol.34 (2), p.524-541

2017

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Metabotropic glutamate 5 receptor blockade may attenuate cocaine self-administration by decreasing brain reward function in rats

Psychopharmacology, 2005-04, Vol.179 (1), p.247-254

2005

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Nicotine potentiation of brain stimulation reward reversed by DHβE and SCH 23390, but not by eticlopride, LY 314582 or MPEP in rats

Psychopharmacologia, 2002-02, Vol.160 (1), p.56-66

2002

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Decrease of mGluR5 receptor density goes parallel with changes in enkephalin and substance P immunoreactivity in Huntington’s disease: a preliminary investigation in the postmortem human brain

Brain Structure and Function, 2015-09, Vol.220 (5), p.3043-3051

2015

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Blockade of the mGlu5 receptor decreases basal and stress-induced cortical norepinephrine in rodents

Psychopharmacology, 2005-04, Vol.179 (1), p.240-246

2005

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Blockade of the mGlu5 receptor decreases basal and stress-induced cortical norepinephrine in rodents: Glutamate Receptor Subtypes: Promising New Pharmacotherapeutic Targets

Psychopharmacologia, 2005, Vol.179 (1), p.240-246

2005

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Nicotine potentiation of brain stimulation reward reversed by DH[Beta]E and SCH 23390, but not by eticlopride, LY 314582 or MPEP in rats

Psychopharmacology, 2002-02, Vol.160 (1), p.56

2002

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Metabotropic glutamate 5 receptor blockade may attenuate cocaine self-administration by decreasing brain reward function in rats: Glutamate Receptor Subtypes: Promising New Pharmacotherapeutic Targets

Psychopharmacologia, 2005, Vol.179 (1), p.247-254

2005

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Hypertension, seizures, and epilepsy: a review on pathophysiology and management

Neurological sciences, 2019-09, Vol.40 (9), p.1775-1783

2019

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Regional hippocampal atrophy reflects memory impairment in patients with early relapsing remitting multiple sclerosis

Journal of neurology, 2024-08, Vol.271 (8), p.4897-4908

2024

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Hypertension, seizures, and epilepsy: a review on pathophysiology and management

Neurological sciences, 2019-09, Vol.40 (9), p.1775-1783

2019

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Polypharmacy in older people: lessons from 10 years of experience with the REPOSI register

Internal and emergency medicine, 2018-12, Vol.13 (8), p.1191-1200

2018

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Frontal lobe dysfunction in essential tremor : A preliminary study

Journal of neurology, 2001-05, Vol.248 (5), p.399-402

2001

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A no-reference metric for demosaicing artifacts that fits psycho-visual experiments

EURASIP journal on advances in signal processing, 2012-06, Vol.2012 (1), p.1-15, Article 123

2012

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Prevalence and Determinants of the Use of Lipid-Lowering Agents in a Population of Older Hospitalized Patients: the Findings from the REPOSI (REgistro POliterapie Società Italiana di Medicina Interna) Study

Drugs & aging, 2017-04, Vol.34 (4), p.311-319

2017

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The challenges of clinical trials in fragile X syndrome

Genetic models of cleavage-reduced and soluble TREM2 reveal distinct effects on myelination and microglia function in the cuprizone model

Fractalkine shedding is mediated by p38 and the ADAM10 protease under pro-inflammatory conditions in human astrocytes

Reciprocal changes in DNA methylation and hydroxymethylation and a broad repressive epigenetic switch characterize FMR1 transcriptional silencing in fragile X syndrome

The mGluR5 antagonist AFQ056 does not affect methylation and transcription of the mutant FMR1 gene in vitro

Radiation dosimetry and biodistribution of 11C-ABP688 measured in healthy volunteers

Fragile X syndrome: a preclinical review on metabotropic glutamate receptor 5 (mGluR5) antagonists and drug development

Rescue of dendritic spine phenotype in Fmr1 KO mice with the mGluR5 antagonist AFQ056/Mavoglurant

Mavoglurant Augmentation in OCD Patients Resistant to Selective Serotonin Reuptake Inhibitors: A Proof-of-Concept, Randomized, Placebo-Controlled, Phase 2 Study

Metabotropic glutamate 5 receptor blockade may attenuate cocaine self-administration by decreasing brain reward function in rats

Nicotine potentiation of brain stimulation reward reversed by DHβE and SCH 23390, but not by eticlopride, LY 314582 or MPEP in rats

Decrease of mGluR5 receptor density goes parallel with changes in enkephalin and substance P immunoreactivity in Huntington’s disease: a preliminary investigation in the postmortem human brain

Blockade of the mGlu5 receptor decreases basal and stress-induced cortical norepinephrine in rodents

Blockade of the mGlu5 receptor decreases basal and stress-induced cortical norepinephrine in rodents: Glutamate Receptor Subtypes: Promising New Pharmacotherapeutic Targets

Nicotine potentiation of brain stimulation reward reversed by DH[Beta]E and SCH 23390, but not by eticlopride, LY 314582 or MPEP in rats

Metabotropic glutamate 5 receptor blockade may attenuate cocaine self-administration by decreasing brain reward function in rats: Glutamate Receptor Subtypes: Promising New Pharmacotherapeutic Targets

Hypertension, seizures, and epilepsy: a review on pathophysiology and management

Regional hippocampal atrophy reflects memory impairment in patients with early relapsing remitting multiple sclerosis

Hypertension, seizures, and epilepsy: a review on pathophysiology and management

Discovering the Italian phenotype of cerebral amyloid angiopathy (CAA): the SENECA project

Antidepressant effect of vagal nerve stimulation in epilepsy patients: a systematic review

Polypharmacy in older people: lessons from 10 years of experience with the REPOSI register

Frontal lobe dysfunction in essential tremor : A preliminary study

A no-reference metric for demosaicing artifacts that fits psycho-visual experiments

Prevalence and Determinants of the Use of Lipid-Lowering Agents in a Population of Older Hospitalized Patients: the Findings from the REPOSI (REgistro POliterapie Società Italiana di Medicina Interna) Study

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