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L-Type amino acid transporter 1 as a target for drug delivery

Pharmaceutical research, 2020-05, Vol.37 (5), p.88-88, Article 88

2020

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L-type amino acid transporter 1 utilizing prodrugs: How to achieve effective brain delivery and low systemic exposure of drugs

Journal of controlled release, 2017-09, Vol.261, p.93-104

2017

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L-Type amino acid transporter 1 (LAT1)-utilizing prodrugs are carrier-selective despite having low affinity for organic anion transporting polypeptides (OATPs)

International journal of pharmaceutics, 2019-11, Vol.571, p.118714, Article 118714

2019

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Pharmacoproteomics of Brain Barrier Transporters and Substrate Design for the Brain Targeted Drug Delivery

Pharmaceutical research, 2022-07, Vol.39 (7), p.1363-1392

2022

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Hemocompatible LAT1-inhibitor can induce apoptosis in cancer cells without affecting brain amino acid homeostasis

Apoptosis (London), 2020-06, Vol.25 (5-6), p.426-440

2020

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Species differences in the intra-brain distribution of an L-type amino acid transporter 1 (LAT1) -utilizing compound between mice and rats

International journal of pharmaceutics, 2021-03, Vol.596, p.120300, Article 120300

2021

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Metformin – a Future Therapy for Neurodegenerative Diseases: Theme: Drug Discovery, Development and Delivery in Alzheimer's Disease Guest Editor: Davide Brambilla

Pharmaceutical research, 2017-12, Vol.34 (12), p.2614-2627

2017

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Amino Acid Promoieties Alter Valproic Acid Pharmacokinetics and Enable Extended Brain Exposure

Neurochemical research, 2016-10, Vol.41 (10), p.2797-2809

2016

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Targeted efflux transporter inhibitors – A solution to improve poor cellular accumulation of anti-cancer agents

International journal of pharmaceutics, 2018-10, Vol.550 (1-2), p.278-289

2018

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L-type amino acid transporter 1 utilizing prodrugs of ferulic acid revealed structural features supporting the design of prodrugs for brain delivery

European journal of pharmaceutical sciences, 2019-03, Vol.129, p.99-109

2019

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Metformin derivatives – Researchers’ friends or foes?

Biochemical pharmacology, 2023-09, Vol.215, p.115743-115743, Article 115743

2023

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Amino acids as promoieties in prodrug design and development

Advanced drug delivery reviews, 2013-10, Vol.65 (10), p.1370-1385

2013

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Orchestrated modulation of rheumatoid arthritis via crosstalking intracellular signaling pathways

Inflammopharmacology, 2021-08, Vol.29 (4), p.965-974

2021

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Amino acid transporters in neurological disorders and neuroprotective effects of cysteine derivatives

Neurochemistry international, 2024-07, Vol.177, p.105771, Article 105771

2024

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Improved l-Type amino acid transporter 1 (LAT1)-mediated delivery of anti-inflammatory drugs into astrocytes and microglia with reduced prostaglandin production

International journal of pharmaceutics, 2021-05, Vol.601, p.120565-120565, Article 120565

2021

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Targeting of Perforin Inhibitor into the Brain Parenchyma Via a Prodrug Approach Can Decrease Oxidative Stress and Neuroinflammation and Improve Cell Survival

Molecular neurobiology, 2020-11, Vol.57 (11), p.4563-4577

2020

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Current approaches to facilitate improved drug delivery to the central nervous system

European journal of pharmaceutics and biopharmaceutics, 2022-12, Vol.181, p.249-262

2022

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L-type amino acid transporter 1 (LAT1)-utilizing efflux transporter inhibitors can improve the brain uptake and apoptosis-inducing effects of vinblastine in cancer cells

International journal of pharmaceutics, 2020-08, Vol.586, p.119585, Article 119585

2020

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Specific transport of temozolomide does not override DNA repair-mediated chemoresistance

European journal of pharmaceutical sciences, 2024-04, Vol.195, p.106661-106661, Article 106661

2024

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Oral genistein-loaded phytosomes with enhanced hepatic uptake, residence and improved therapeutic efficacy against hepatocellular carcinoma

International journal of pharmaceutics, 2021-05, Vol.601, p.120564-120564, Article 120564

2021

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Alzheimer’s Disease Phenotype or Inflammatory Insult Does Not Alter Function of L-Type Amino Acid Transporter 1 in Mouse Blood-Brain Barrier and Primary Astrocytes

Pharmaceutical research, 2019-01, Vol.36 (1), p.17-8, Article 17

2019

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l-Type amino acid transporter 1 (lat1)-mediated targeted delivery of perforin inhibitors

International journal of pharmaceutics, 2016-02, Vol.498 (1-2), p.205-216

2016

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Enhanced drug delivery by a prodrug approach effectively relieves neuroinflammation in mice

Life sciences (1973), 2022-12, Vol.310, p.121088-121088, Article 121088

2022

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New prodrugs of metformin do not influence the overall haemostasis potential and integrity of the erythrocyte membrane

European journal of pharmacology, 2017-09, Vol.811, p.208-221

2017

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Altering distribution profile of palbociclib by its prodrugs

European journal of pharmaceutical sciences, 2024-01, Vol.192, p.106637-106637, Article 106637

2024

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L-Type amino acid transporter 1 as a target for drug delivery

L-type amino acid transporter 1 utilizing prodrugs: How to achieve effective brain delivery and low systemic exposure of drugs

L-Type amino acid transporter 1 (LAT1)-utilizing prodrugs are carrier-selective despite having low affinity for organic anion transporting polypeptides (OATPs)

Pharmacoproteomics of Brain Barrier Transporters and Substrate Design for the Brain Targeted Drug Delivery

Hemocompatible LAT1-inhibitor can induce apoptosis in cancer cells without affecting brain amino acid homeostasis

Species differences in the intra-brain distribution of an L-type amino acid transporter 1 (LAT1) -utilizing compound between mice and rats

Metformin – a Future Therapy for Neurodegenerative Diseases: Theme: Drug Discovery, Development and Delivery in Alzheimer's Disease Guest Editor: Davide Brambilla

Amino Acid Promoieties Alter Valproic Acid Pharmacokinetics and Enable Extended Brain Exposure

Targeted efflux transporter inhibitors – A solution to improve poor cellular accumulation of anti-cancer agents

L-type amino acid transporter 1 utilizing prodrugs of ferulic acid revealed structural features supporting the design of prodrugs for brain delivery

Metformin derivatives – Researchers’ friends or foes?

Amino acids as promoieties in prodrug design and development

Orchestrated modulation of rheumatoid arthritis via crosstalking intracellular signaling pathways

Amino acid transporters in neurological disorders and neuroprotective effects of cysteine derivatives

Improved l-Type amino acid transporter 1 (LAT1)-mediated delivery of anti-inflammatory drugs into astrocytes and microglia with reduced prostaglandin production

Targeting of Perforin Inhibitor into the Brain Parenchyma Via a Prodrug Approach Can Decrease Oxidative Stress and Neuroinflammation and Improve Cell Survival

Current approaches to facilitate improved drug delivery to the central nervous system

L-type amino acid transporter 1 (LAT1)-utilizing efflux transporter inhibitors can improve the brain uptake and apoptosis-inducing effects of vinblastine in cancer cells

Specific transport of temozolomide does not override DNA repair-mediated chemoresistance

Oral genistein-loaded phytosomes with enhanced hepatic uptake, residence and improved therapeutic efficacy against hepatocellular carcinoma

Alzheimer’s Disease Phenotype or Inflammatory Insult Does Not Alter Function of L-Type Amino Acid Transporter 1 in Mouse Blood-Brain Barrier and Primary Astrocytes

l-Type amino acid transporter 1 (lat1)-mediated targeted delivery of perforin inhibitors

Enhanced drug delivery by a prodrug approach effectively relieves neuroinflammation in mice

New prodrugs of metformin do not influence the overall haemostasis potential and integrity of the erythrocyte membrane

Altering distribution profile of palbociclib by its prodrugs

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