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Target-Mediated Drug Disposition Pharmacokinetic–Pharmacodynamic Model of Bosentan and Endothelin-1

Clinical pharmacokinetics, 2017-12, Vol.56 (12), p.1499-1511

2017

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Clinical Pharmacology of Endothelin Receptor Antagonists Used in the Treatment of Pulmonary Arterial Hypertension

American journal of cardiovascular drugs : drugs, devices, and other interventions, 2015-02, Vol.15 (1), p.13-26

2015

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Clinical Pharmacokinetics and Pharmacodynamics of the Endothelin Receptor Antagonist Macitentan

Clinical pharmacokinetics, 2015-05, Vol.54 (5), p.457-471

2015

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Single-Dose Pharmacokinetics and Tolerability of Aprocitentan, a Dual Endothelin Receptor Antagonist, in Subjects with Severe Renal Function Impairment

Clinical drug investigation, 2019-11, Vol.39 (11), p.1117-1123

2019

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Effect of Combination Therapy of Endothelin Receptor Antagonist and Phosphodiesterase-5 Inhibitor on Clinical Outcome and Pulmonary Haemodynamics in Patients with Pulmonary Arterial Hypertension: A Meta-Analysis

Clinical drug investigation, 2019-11, Vol.39 (11), p.1031-1044

2019

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Comparative Safety and Tolerability of Endothelin Receptor Antagonists in Pulmonary Arterial Hypertension

Drug safety, 2015-05, Vol.38 (5), p.419-435

2015

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Macitentan: A Review in Pulmonary Arterial Hypertension

American journal of cardiovascular drugs : drugs, devices, and other interventions, 2016-12, Vol.16 (6), p.453-460

Keating, Gillian M.

2016

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Surveillance on The Safety and Efficacy of Ambrisentan (Volibris Tablet 2.5 mg) in Patients with Pulmonary Arterial Hypertension in Real Clinical Practice: Post-marketing Surveillance (Interim Analysis Report)

Clinical drug investigation, 2018-03, Vol.38 (3), p.219-229

2018

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Pharmacokinetic–Pharmacodynamic Relationships of Macitentan, a New Endothelin Receptor Antagonist, After Multiple Dosing in Healthy Korean Subjects

American journal of cardiovascular drugs : drugs, devices, and other interventions, 2014-10, Vol.14 (5), p.377-385

2014

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Physiologically-Based Pharmacokinetic Modeling of Macitentan: Prediction of Drug–Drug Interactions

Clinical pharmacokinetics, 2016-03, Vol.55 (3), p.369-380

2016

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Investigation of the Effects of Ketoconazole on the Pharmacokinetics of Macitentan, a Novel Dual Endothelin Receptor Antagonist, in Healthy Subjects

Clinical pharmacokinetics, 2013-08, Vol.52 (8), p.685-692

2013

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Effect of Cyclosporine and Rifampin on the Pharmacokinetics of Macitentan, a Tissue-Targeting Dual Endothelin Receptor Antagonist

The AAPS journal, 2012-03, Vol.14 (1), p.68-78

2012

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Endothelin Receptor Antagonists for Pulmonary Arterial Hypertension: Rationale and Place in Therapy

American journal of cardiovascular drugs : drugs, devices, and other interventions, 2008-01, Vol.8 (3), p.171-185

2008

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Overexpression of endothelin B receptor in glioblastoma: a prognostic marker and therapeutic target?

BMC cancer, 2018-02, Vol.18 (1), p.154-154, Article 154

2018

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RAGE mediates amyloid-β peptide transport across the blood-brain barrier and accumulation in brain

Nature medicine, 2003-07, Vol.9 (7), p.907-913

2003

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Targeted Oral Therapies in the Treatment of Pulmonary Arterial Hypertension

Clinical drug investigation, 2010-01, Vol.30 (12), p.811-826

Safdar, Zeenat

2010

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Effects of exogenous big endothelin-1 on postischemic cardiac dysfunction and norepinephrine overflow in rat hearts

Hypertension research, 2011-02, Vol.34 (2), p.218-224

2011

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Effects of Rifampicin (Rifampin) on the Pharmacokinetics and Safety of Ambrisentan in Healthy Subjects: A Single-Sequence, Open-Label Study

Clinical drug investigation, 2010-01, Vol.30 (12), p.875-885

2010

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Endothelin-1 mediates hypoxia-induced increases in vascular collagen in the newborn mouse lung

Pediatric research, 2007-05, Vol.61 (5), p.559-564

2007

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Adherence and Discontinuation of Disease-Specific Therapies for Pulmonary Arterial Hypertension: A Systematic Review and Meta-Analysis

American journal of cardiovascular drugs : drugs, devices, and other interventions, 2023, Vol.23 (1), p.19-33

2023

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Randomized study of adding tadalafil to existing ambrisentan in pulmonary arterial hypertension

Hypertension research, 2014-06, Vol.37 (6), p.507-512

2014

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Next generation multifunctional angiotensin receptor blockers

Hypertension research, 2009-10, Vol.32 (10), p.826-834

2009

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Clinical pharmacology of bosentan, a dual endothelin receptor antagonist

Clinical pharmacokinetics, 2004-01, Vol.43 (15), p.1089-1115

2004

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Drug Treatment of Pulmonary Hypertension in Children

Paediatric drugs, 2014-02, Vol.16 (1), p.43-65

2014

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New therapeutics that antagonize endothelin: promises and frustrations

Nature reviews. Drug discovery, 2002-12, Vol.1 (12), p.986-1001

2002

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Target-Mediated Drug Disposition Pharmacokinetic–Pharmacodynamic Model of Bosentan and Endothelin-1

Clinical Pharmacology of Endothelin Receptor Antagonists Used in the Treatment of Pulmonary Arterial Hypertension

Clinical Pharmacokinetics and Pharmacodynamics of the Endothelin Receptor Antagonist Macitentan

Single-Dose Pharmacokinetics and Tolerability of Aprocitentan, a Dual Endothelin Receptor Antagonist, in Subjects with Severe Renal Function Impairment

Effect of Combination Therapy of Endothelin Receptor Antagonist and Phosphodiesterase-5 Inhibitor on Clinical Outcome and Pulmonary Haemodynamics in Patients with Pulmonary Arterial Hypertension: A Meta-Analysis

Comparative Safety and Tolerability of Endothelin Receptor Antagonists in Pulmonary Arterial Hypertension

Macitentan: A Review in Pulmonary Arterial Hypertension

Surveillance on The Safety and Efficacy of Ambrisentan (Volibris Tablet 2.5 mg) in Patients with Pulmonary Arterial Hypertension in Real Clinical Practice: Post-marketing Surveillance (Interim Analysis Report)

Pharmacokinetic–Pharmacodynamic Relationships of Macitentan, a New Endothelin Receptor Antagonist, After Multiple Dosing in Healthy Korean Subjects

Physiologically-Based Pharmacokinetic Modeling of Macitentan: Prediction of Drug–Drug Interactions

Investigation of the Effects of Ketoconazole on the Pharmacokinetics of Macitentan, a Novel Dual Endothelin Receptor Antagonist, in Healthy Subjects

Effect of Cyclosporine and Rifampin on the Pharmacokinetics of Macitentan, a Tissue-Targeting Dual Endothelin Receptor Antagonist

Endothelin Receptor Antagonists for Pulmonary Arterial Hypertension: Rationale and Place in Therapy

Overexpression of endothelin B receptor in glioblastoma: a prognostic marker and therapeutic target?

RAGE mediates amyloid-β peptide transport across the blood-brain barrier and accumulation in brain

Targeted Oral Therapies in the Treatment of Pulmonary Arterial Hypertension

Effects of exogenous big endothelin-1 on postischemic cardiac dysfunction and norepinephrine overflow in rat hearts

Effects of Rifampicin (Rifampin) on the Pharmacokinetics and Safety of Ambrisentan in Healthy Subjects: A Single-Sequence, Open-Label Study

Endothelin-1 mediates hypoxia-induced increases in vascular collagen in the newborn mouse lung

Adherence and Discontinuation of Disease-Specific Therapies for Pulmonary Arterial Hypertension: A Systematic Review and Meta-Analysis

Randomized study of adding tadalafil to existing ambrisentan in pulmonary arterial hypertension

Next generation multifunctional angiotensin receptor blockers

Clinical pharmacology of bosentan, a dual endothelin receptor antagonist

Drug Treatment of Pulmonary Hypertension in Children

New therapeutics that antagonize endothelin: promises and frustrations

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