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Deguelin targets multiple oncogenic signaling pathways to combat human malignancies

Pharmacological research, 2021-04, Vol.166, p.105487-105487, Article 105487

2021

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Biopharmacological considerations for accelerating drug development of deguelin, a rotenoid with potent chemotherapeutic and chemopreventive potential

Cancer, 2019-06, Vol.125 (11), p.1789-1798

2019

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Mitochondrial Complex I Inhibitors Expose a Vulnerability for Selective Killing of Pten-Null Cells

Cell reports (Cambridge), 2018-04, Vol.23 (1), p.58-67

2018

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A novel C-terminal heat shock protein 90 inhibitor that overcomes STAT3-Wnt-β-catenin signaling-mediated drug resistance and adverse effects

Theranostics, 2022, Vol.12 (1), p.105-125

2022

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Deguelin inhibits non-small cell lung cancer via down-regulating Hexokinases II-mediated glycolysis

Oncotarget, 2017-05, Vol.8 (20), p.32586-32599

2017

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Pharmacological basis and new insights of deguelin concerning its anticancer effects

Pharmacological research, 2021-12, Vol.174, p.105935-105935, Article 105935

2021

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Discovery of indazole inhibitors for heat shock protein 90 as anti-cancer agents

European journal of medicinal chemistry, 2024-10, Vol.276, p.116620, Article 116620

2024

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Inhibition of Autophagy by Deguelin Sensitizes Pancreatic Cancer Cells to Doxorubicin

International journal of molecular sciences, 2017-02, Vol.18 (2), p.370-370

2017

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Recent advances in flavonoid compounds for the treatment of prostate cancer

Molecular biology reports, 2024-12, Vol.51 (1), p.653-653, Article 653

2024

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Repression of Noxa by Bmi1 contributes to deguelin‐induced apoptosis in non‐small cell lung cancer cells

Journal of cellular and molecular medicine, 2018-12, Vol.22 (12), p.6213-6227

2018

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Investigation of B,C-ring truncated deguelin derivatives as heat shock protein 90 (HSP90) inhibitors for use as anti-breast cancer agents

Bioorganic & medicinal chemistry, 2019-04, Vol.27 (7), p.1370-1381

2019

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Intestinal deguelin drives resistance to acetaminophen-induced hepatotoxicity in female mice

Gut microbes, 2024-01, Vol.16 (1), p.2404138

2024

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Highly Variable Insect Control Efficacy of Tephrosia vogelii Chemotypes

Journal of agricultural and food chemistry, 2012-10, Vol.60 (40), p.10055-10063

2012

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Selective activity of deguelin identifies therapeutic targets for androgen receptor-positive breast cancer

Breast cancer research and treatment, 2016-06, Vol.157 (3), p.475-488

2016

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Deguelin inhibits the proliferation of human multiple myeloma cells by inducing apoptosis and G2/M cell cycle arrest: Involvement of Akt and p38 MAPK signalling pathway

Acta pharmaceutica (Zagreb, Croatia), 2024-03, Vol.74 (1), p.101-115

2024

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Screening of a small, well-curated natural product-based library identifies two rotenoids with potent nematocidal activity against Haemonchus contortus

Veterinary parasitology, 2017-09, Vol.244, p.172-175

2017

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Synthesis and biological evaluation of C-ring truncated deguelin derivatives as heat shock protein 90 (HSP90) inhibitors

Bioorganic & medicinal chemistry, 2016-11, Vol.24 (22), p.6082-6093

2016

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Deguelin inhibits RANKL‐induced osteoclastogenesis in vitro and prevents inflammation‐mediated bone loss in vivo

Journal of cellular physiology, 2019-03, Vol.234 (3), p.2719-2729

2019

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Deguelin and Paclitaxel Loaded PEG-PCL Nano-Micelles for Suppressing the Proliferation and Inducing Apoptosis of Breast Cancer Cells

Frontiers in bioscience (Landmark. Print), 2024-02, Vol.29 (2), p.90-90

2024

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Deguelin inhibits the migration and invasion of U-2 OS human osteosarcoma cells via the inhibition of matrix metalloproteinase-2/-9 in vitro

Molecules (Basel, Switzerland), 2014-10, Vol.19 (10), p.16588-16608

2014

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The Natural Rotenoid Deguelin Ameliorates Diabetic Neuropathy by Decreasing Oxidative Stress and Plasma Glucose Levels in Rats via the Nrf2 Signalling Pathway

Cellular physiology and biochemistry, 2018-08, Vol.48 (3), p.1164-1176

2018

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Ring-truncated deguelin derivatives as potent Hypoxia Inducible Factor-1α (HIF-1α) inhibitors

European journal of medicinal chemistry, 2015-11, Vol.104, p.157-164

2015

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Inhibition of Survivin Restores the Sensitivity of Breast Cancer Cells to Docetaxel and Vinblastine

Applied biochemistry and biotechnology, 2014-09, Vol.174 (2), p.667-681

2014

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Deguelin, an Aurora B Kinase Inhibitor, Exhibits Potent Anti-Tumor Effect in Human Esophageal Squamous Cell Carcinoma

EBioMedicine, 2017-12, Vol.26 (C), p.100-111

2017

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Natural product-inspired rational design, synthesis and biological evaluation of 2,3-dihydropyrano[2,3-f]chromen-4(8H)-one based hybrids as potential mitochondrial apoptosis inducers

European journal of medicinal chemistry, 2016-10, Vol.122, p.302-318

2016

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Deguelin targets multiple oncogenic signaling pathways to combat human malignancies

Biopharmacological considerations for accelerating drug development of deguelin, a rotenoid with potent chemotherapeutic and chemopreventive potential

Mitochondrial Complex I Inhibitors Expose a Vulnerability for Selective Killing of Pten-Null Cells

A novel C-terminal heat shock protein 90 inhibitor that overcomes STAT3-Wnt-β-catenin signaling-mediated drug resistance and adverse effects

Deguelin inhibits non-small cell lung cancer via down-regulating Hexokinases II-mediated glycolysis

Pharmacological basis and new insights of deguelin concerning its anticancer effects

Discovery of indazole inhibitors for heat shock protein 90 as anti-cancer agents

Inhibition of Autophagy by Deguelin Sensitizes Pancreatic Cancer Cells to Doxorubicin

Recent advances in flavonoid compounds for the treatment of prostate cancer

Repression of Noxa by Bmi1 contributes to deguelin‐induced apoptosis in non‐small cell lung cancer cells

Investigation of B,C-ring truncated deguelin derivatives as heat shock protein 90 (HSP90) inhibitors for use as anti-breast cancer agents

Intestinal deguelin drives resistance to acetaminophen-induced hepatotoxicity in female mice

Highly Variable Insect Control Efficacy of Tephrosia vogelii Chemotypes

Selective activity of deguelin identifies therapeutic targets for androgen receptor-positive breast cancer

Deguelin inhibits the proliferation of human multiple myeloma cells by inducing apoptosis and G2/M cell cycle arrest: Involvement of Akt and p38 MAPK signalling pathway

Screening of a small, well-curated natural product-based library identifies two rotenoids with potent nematocidal activity against Haemonchus contortus

Synthesis and biological evaluation of C-ring truncated deguelin derivatives as heat shock protein 90 (HSP90) inhibitors

Deguelin inhibits RANKL‐induced osteoclastogenesis in vitro and prevents inflammation‐mediated bone loss in vivo

Deguelin and Paclitaxel Loaded PEG-PCL Nano-Micelles for Suppressing the Proliferation and Inducing Apoptosis of Breast Cancer Cells

Deguelin inhibits the migration and invasion of U-2 OS human osteosarcoma cells via the inhibition of matrix metalloproteinase-2/-9 in vitro

The Natural Rotenoid Deguelin Ameliorates Diabetic Neuropathy by Decreasing Oxidative Stress and Plasma Glucose Levels in Rats via the Nrf2 Signalling Pathway

Ring-truncated deguelin derivatives as potent Hypoxia Inducible Factor-1α (HIF-1α) inhibitors

Inhibition of Survivin Restores the Sensitivity of Breast Cancer Cells to Docetaxel and Vinblastine

Deguelin, an Aurora B Kinase Inhibitor, Exhibits Potent Anti-Tumor Effect in Human Esophageal Squamous Cell Carcinoma

Natural product-inspired rational design, synthesis and biological evaluation of 2,3-dihydropyrano[2,3-f]chromen-4(8H)-one based hybrids as potential mitochondrial apoptosis inducers

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