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Camelid Single-Domain Antibodies: Promises and Challenges as Lifesaving Treatments

International journal of molecular sciences, 2022-04, Vol.23 (9), p.5009

Arbabi-Ghahroudi, Mehdi

2022

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Molecular basis for thermal stability and affinity in a VHH: Contribution of the framework region and its influence in the conformation of the CDR3

Protein science, 2022-11, Vol.31 (11), p.e4450-n/a

2022

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X-ray Crystal Structure Analysis of VHH-Protein Antigen Complexes

Methods in molecular biology (Clifton, N.J.), 2022, Vol.2446, p.513

2022

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Nanobodies: natural single-domain antibodies

Annual review of biochemistry, 2013-01, Vol.82 (1), p.775-797

Muyldermans, Serge

2013

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Inhibition of Tau seeding by targeting Tau nucleation core within neurons with a single domain antibody fragment

Molecular therapy, 2022-04, Vol.30 (4), p.1484-1499

2022

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Nanobodies: Robust miniprotein binders in biomedicine

Advanced drug delivery reviews, 2023-04, Vol.195, p.114726-114726, Article 114726

2023

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Evaluating single-domain antibodies as carriers for targeted vaccine delivery to the small intestinal epithelium

Journal of controlled release, 2020-05, Vol.321, p.416-429

2020

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Beyond bispecificity: Controlled Fab arm exchange for the generation of antibodies with multiple specificities

mAbs, 2022, Vol.14 (1), p.2018960-2018960

2022

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Nanobodies: From Serendipitous Discovery of Heavy Chain-Only Antibodies in Camelids to a Wide Range of Useful Applications

Methods in molecular biology (Clifton, N.J.), 2022, Vol.2446, p.3

2022

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Comparative analysis of nanobody sequence and structure data

Proteins, structure, function, and bioinformatics, 2018-07, Vol.86 (7), p.697-706

2018

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IgG-VHH bispecific fusion antibodies: challenges and opportunities as therapeutic agents

Expert opinion on biological therapy, 2024-04, Vol.24 (4), p.203-206

2024

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Targeting tumors with nanobodies for cancer imaging and therapy

Journal of controlled release, 2013-12, Vol.172 (3), p.607-617

2013

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Facile discovery of surrogate cytokine agonists

Cell, 2022-04, Vol.185 (8), p.1414-1430.e19

2022

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Recent advances in the selection and identification of antigen-specific nanobodies

Molecular immunology, 2018-04, Vol.96, p.37-47

2018

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An anti‐hapten camelid antibody reveals a cryptic binding site with significant energetic contributions from a nonhypervariable loop

Protein science, 2011-07, Vol.20 (7), p.1196-1207

2011

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On the humanization of VHHs: Prospective case studies, experimental and computational characterization of structural determinants for functionality

Protein science, 2024-11, Vol.33 (11), p.e5176-n/a

2024

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Nanobodies as molecular imaging probes

Free radical biology & medicine, 2022-03, Vol.182, p.260-275

2022

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Nanobody-based cancer therapy of solid tumors

Nanomedicine (London, England), 2015-01, Vol.10 (1), p.161-174

2015

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GlycoVHH: optimal sites for introducing N-glycans on the camelid VHH antibody scaffold and use for macrophage delivery

mAbs, 2023, Vol.15 (1), p.2210709-2210709

2023

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A potent bispecific nanobody protects hACE2 mice against SARS-CoV-2 infection via intranasal administration

Cell reports (Cambridge), 2021-10, Vol.37 (3), p.109869-109869, Article 109869

2021

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MICA-specific nanobodies for diagnosis and immunotherapy of MICA + tumors

Frontiers in immunology, 2024-03, Vol.15, p.1368586-1368586

2024

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Ultrasensitive and rapid colorimetric detection of paraquat via a high specific VHH nanobody

Biosensors & bioelectronics, 2022-06, Vol.205, p.114089-114089, Article 114089

2022

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Identification and characterization of a new 34 kDa MORN motif-containing sporozoite surface-exposed protein, Cp-P34, unique to Cryptosporidium

International journal for parasitology, 2021-08, Vol.51 (9), p.761-775

2021

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Ozoralizumab, a Humanized Anti-TNFα NANOBODY ® Compound, Exhibits Efficacy Not Only at the Onset of Arthritis in a Human TNF Transgenic Mouse but Also During Secondary Failure of Administration of an Anti-TNFα IgG

Frontiers in immunology, 2022-02, Vol.13, p.853008-853008

2022

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Analysis of nanobody paratopes reveals greater diversity than classical antibodies

Protein engineering, design and selection, 2018-07, Vol.31 (7-8), p.267-275

2018

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Camelid Single-Domain Antibodies: Promises and Challenges as Lifesaving Treatments

Molecular basis for thermal stability and affinity in a VHH: Contribution of the framework region and its influence in the conformation of the CDR3

X-ray Crystal Structure Analysis of VHH-Protein Antigen Complexes

Nanobodies: natural single-domain antibodies

Inhibition of Tau seeding by targeting Tau nucleation core within neurons with a single domain antibody fragment

Nanobodies: Robust miniprotein binders in biomedicine

Evaluating single-domain antibodies as carriers for targeted vaccine delivery to the small intestinal epithelium

Beyond bispecificity: Controlled Fab arm exchange for the generation of antibodies with multiple specificities

Nanobodies: From Serendipitous Discovery of Heavy Chain-Only Antibodies in Camelids to a Wide Range of Useful Applications

Comparative analysis of nanobody sequence and structure data

IgG-VHH bispecific fusion antibodies: challenges and opportunities as therapeutic agents

Targeting tumors with nanobodies for cancer imaging and therapy

Facile discovery of surrogate cytokine agonists

Recent advances in the selection and identification of antigen-specific nanobodies

An anti‐hapten camelid antibody reveals a cryptic binding site with significant energetic contributions from a nonhypervariable loop

On the humanization of VHHs: Prospective case studies, experimental and computational characterization of structural determinants for functionality

Nanobodies as molecular imaging probes

Nanobody-based cancer therapy of solid tumors

GlycoVHH: optimal sites for introducing N-glycans on the camelid VHH antibody scaffold and use for macrophage delivery

A potent bispecific nanobody protects hACE2 mice against SARS-CoV-2 infection via intranasal administration

MICA-specific nanobodies for diagnosis and immunotherapy of MICA + tumors

Ultrasensitive and rapid colorimetric detection of paraquat via a high specific VHH nanobody

Identification and characterization of a new 34 kDa MORN motif-containing sporozoite surface-exposed protein, Cp-P34, unique to Cryptosporidium

Ozoralizumab, a Humanized Anti-TNFα NANOBODY ® Compound, Exhibits Efficacy Not Only at the Onset of Arthritis in a Human TNF Transgenic Mouse but Also During Secondary Failure of Administration of an Anti-TNFα IgG

Analysis of nanobody paratopes reveals greater diversity than classical antibodies

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