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The Role of Heme and the Mitochondrion in the Chemical and Molecular Mechanisms of Mammalian Cell Death Induced by the Artemisinin Antimalarials

The Journal of biological chemistry, 2011-01, Vol.286 (2), p.987-996

2011

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Evidence for the Involvement of Carbon-centered Radicals in the Induction of Apoptotic Cell Death by Artemisinin Compounds

The Journal of biological chemistry, 2007-03, Vol.282 (13), p.9372-9382

2007

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The role of metabolic activation in drug-induced hepatotoxicity

Annual review of pharmacology and toxicology, 2005-01, Vol.45 (1), p.177-202

2005

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Acyl glucuronides: the good, the bad and the ugly

Biopharmaceutics & drug disposition, 2010-10, Vol.31 (7), p.367-395

2010

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Mass Spectrometric Characterization of Circulating Covalent Protein Adducts Derived from Epoxide Metabolites of Carbamazepine in Patients

Chemical research in toxicology, 2017-07, Vol.30 (7), p.1419-1435

2017

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Mass spectrometric characterization of circulating covalent protein adducts derived from a drug acyl glucuronide metabolite: multiple albumin adductions in diclofenac patients

The Journal of pharmacology and experimental therapeutics, 2014-08, Vol.350 (2), p.387-402

2014

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Direct evidence for the formation of diastereoisomeric benzylpenicilloyl haptens from benzylpenicillin and benzylpenicillenic acid in patients

The Journal of pharmacology and experimental therapeutics, 2011-09, Vol.338 (3), p.841-849

2011

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Quantifying the metabolic activation of nevirapine in patients by integrated applications of NMR and mass spectrometries

Drug metabolism and disposition, 2010-01, Vol.38 (1), p.122-132

2010

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Syntheses and Characterization of the Acyl Glucuronide and Hydroxy Metabolites of Diclofenac

Journal of medicinal chemistry, 2004-05, Vol.47 (11), p.2816-2825

2004

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Evaluation of clinical and genetic factors in the population pharmacokinetics of carbamazepine

British journal of clinical pharmacology, 2021-06, Vol.87 (6), p.2572-2588

2021

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Covalent Binding of the Nitroso Metabolite of Sulfamethoxazole Leads to Toxicity and Major Histocompatibility Complex-Restricted Antigen Presentation

Molecular pharmacology, 2002-09, Vol.62 (3), p.628-637

2002

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Glucuronidation of dihydroartemisinin in vivo and by human liver microsomes and expressed UDP-glucuronosyltransferases

Drug metabolism and disposition, 2002-09, Vol.30 (9), p.1005-1012

2002

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Identification of the thiophene ring of methapyrilene as a novel bioactivation-dependent hepatic toxicophore

The Journal of pharmacology and experimental therapeutics, 2008-08, Vol.326 (2), p.657-671

2008

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Activation of human dendritic cells by p-phenylenediamine

The Journal of pharmacology and experimental therapeutics, 2007-02, Vol.320 (2), p.885-892

2007

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Characterisation of the NRF2 transcriptional network and its response to chemical insult in primary human hepatocytes: implications for prediction of drug-induced liver injury

Archives of toxicology, 2019-02, Vol.93 (2), p.385-399

2019

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Enzyme-Induction Dependent Bioactivation of Troglitazone and Troglitazone Quinone In Vivo

Chemical research in toxicology, 2001-08, Vol.14 (8), p.965-974

2001

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Auto-oxidation of Isoniazid Leads to Isonicotinic-Lysine Adducts on Human Serum Albumin

Chemical research in toxicology, 2015-01, Vol.28 (1), p.51-58

2015

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Comparison of the Reactivity of Antimalarial 1,2,4,5-Tetraoxanes with 1,2,4-Trioxolanes in the Presence of Ferrous Iron Salts, Heme, and Ferrous Iron Salts/Phosphatidylcholine

Journal of medicinal chemistry, 2011-10, Vol.54 (19), p.6443-6455

2011

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Dapsone and Nitroso Dapsone Activation of Naı̈ve T‑Cells from Healthy Donors

Chemical research in toxicology, 2017-12, Vol.30 (12), p.2174-2186

2017

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Metabolism of Lamotrigine to a Reactive Arene Oxide Intermediate

Chemical research in toxicology, 2000-11, Vol.13 (11), p.1075-1081

2000

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Characterization of Peroxidases Expressed in Human Antigen Presenting Cells and Analysis of the Covalent Binding of Nitroso Sulfamethoxazole to Myeloperoxidase

Chemical research in toxicology, 2015-01, Vol.28 (1), p.144-154

2015

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Acyl Glucuronides: Biological Activity, Chemical Reactivity, and Chemical Synthesis

Journal of medicinal chemistry, 2006-11, Vol.49 (24), p.6931-6945

2006

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Nonenzymatic formation of a novel hydroxylated sulfamethoxazole derivative in human liver microsomes: implications for bioanalysis of sulfamethoxazole metabolites

Drug metabolism and disposition, 2008-12, Vol.36 (12), p.2424-2428

2008

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Convenient syntheses of halo-dibenz[b,f]azepines and carbamazepine analogues via N-arylindoles

Organic & biomolecular chemistry, 2013-12, Vol.11 (48), p.8426-8434

2013

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Multiple Adduction Reactions of Nitroso Sulfamethoxazole with Cysteinyl Residues of Peptides and Proteins: Implications for Hapten Formation

Chemical research in toxicology, 2009-05, Vol.22 (5), p.937-948

2009

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The Role of Heme and the Mitochondrion in the Chemical and Molecular Mechanisms of Mammalian Cell Death Induced by the Artemisinin Antimalarials

Evidence for the Involvement of Carbon-centered Radicals in the Induction of Apoptotic Cell Death by Artemisinin Compounds

The role of metabolic activation in drug-induced hepatotoxicity

Acyl glucuronides: the good, the bad and the ugly

Mass Spectrometric Characterization of Circulating Covalent Protein Adducts Derived from Epoxide Metabolites of Carbamazepine in Patients

Mass spectrometric characterization of circulating covalent protein adducts derived from a drug acyl glucuronide metabolite: multiple albumin adductions in diclofenac patients

Direct evidence for the formation of diastereoisomeric benzylpenicilloyl haptens from benzylpenicillin and benzylpenicillenic acid in patients

Quantifying the metabolic activation of nevirapine in patients by integrated applications of NMR and mass spectrometries

Syntheses and Characterization of the Acyl Glucuronide and Hydroxy Metabolites of Diclofenac

Evaluation of clinical and genetic factors in the population pharmacokinetics of carbamazepine

Covalent Binding of the Nitroso Metabolite of Sulfamethoxazole Leads to Toxicity and Major Histocompatibility Complex-Restricted Antigen Presentation

Glucuronidation of dihydroartemisinin in vivo and by human liver microsomes and expressed UDP-glucuronosyltransferases

Identification of the thiophene ring of methapyrilene as a novel bioactivation-dependent hepatic toxicophore

Activation of human dendritic cells by p-phenylenediamine

Characterisation of the NRF2 transcriptional network and its response to chemical insult in primary human hepatocytes: implications for prediction of drug-induced liver injury

Enzyme-Induction Dependent Bioactivation of Troglitazone and Troglitazone Quinone In Vivo

Auto-oxidation of Isoniazid Leads to Isonicotinic-Lysine Adducts on Human Serum Albumin

Comparison of the Reactivity of Antimalarial 1,2,4,5-Tetraoxanes with 1,2,4-Trioxolanes in the Presence of Ferrous Iron Salts, Heme, and Ferrous Iron Salts/Phosphatidylcholine

Dapsone and Nitroso Dapsone Activation of Naı̈ve T‑Cells from Healthy Donors

Metabolism of Lamotrigine to a Reactive Arene Oxide Intermediate

Characterization of Peroxidases Expressed in Human Antigen Presenting Cells and Analysis of the Covalent Binding of Nitroso Sulfamethoxazole to Myeloperoxidase

Acyl Glucuronides: Biological Activity, Chemical Reactivity, and Chemical Synthesis

Nonenzymatic formation of a novel hydroxylated sulfamethoxazole derivative in human liver microsomes: implications for bioanalysis of sulfamethoxazole metabolites

Convenient syntheses of halo-dibenz[b,f]azepines and carbamazepine analogues via N-arylindoles

Multiple Adduction Reactions of Nitroso Sulfamethoxazole with Cysteinyl Residues of Peptides and Proteins: Implications for Hapten Formation

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