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Lipids on Trial: The Search for the Offending Metabolite in Niemann-Pick type C Disease

Traffic (Copenhagen, Denmark), 2010-04, Vol.11 (4), p.419-428

2010

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PIP2 depletion and altered endocytosis caused by expression of Alzheimer's disease‐protective variant PLCγ2 R522

The EMBO journal, 2021-09, Vol.40 (17), p.e105603-n/a

2021

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Endolysosomal calcium regulation and disease

Biochemical Society transactions, 2010-12, Vol.38 (6), p.1458-1464

2010

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Regulation of TRPML1 function

Biochemical Society transactions, 2015-06, Vol.43 (3), p.442-446

2015

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Unbiased Cell-based Screening in a Neuronal Cell Model of Batten Disease Highlights an Interaction between Ca2+ Homeostasis, Autophagy, and CLN3 Protein Function

The Journal of biological chemistry, 2015-06, Vol.290 (23), p.14361-14380

2015

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A rapid method for the preparation of ultrapure, functional lysosomes using functionalized superparamagnetic iron oxide nanoparticles

Methods in cell biology, 2015, Vol.126, p.21-43

2015

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The Crystal Structure of Bacillus thuringiensis Tpp80Aa1 and Its Interaction with Galactose-Containing Glycolipids

Toxins, 2022-12, Vol.14 (12), p.863

2022

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Compromised astrocyte function and survival negatively impact neurons in infantile neuronal ceroid lipofuscinosis

Acta neuropathologica communications, 2018-08, Vol.6 (1), p.74-74, Article 74

2018

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Enhanced calcium release in the acute neuronopathic form of Gaucher disease

Neurobiology of disease, 2005-02, Vol.18 (1), p.83-88

2005

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Glucosylceramide and Glucosylsphingosine Modulate Calcium Mobilization from Brain Microsomes via Different Mechanisms

The Journal of biological chemistry, 2003-06, Vol.278 (26), p.23594-23599

2003

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Accumulation of Glycosphingolipids in Niemann-Pick C Disease Disrupts Endosomal Transport

The Journal of biological chemistry, 2004-06, Vol.279 (25), p.26167-26175

2004

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Inhibition of Calcium Uptake via the Sarco/Endoplasmic Reticulum Ca2+-ATPase in a Mouse Model of Sandhoff Disease and Prevention by Treatment with N-Butyldeoxynojirimycin

The Journal of biological chemistry, 2003-08, Vol.278 (32), p.29496-29501

2003

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Treatment with miglustat reverses the lipid-trafficking defect in Niemann–Pick disease type C

Neurobiology of disease, 2004-08, Vol.16 (3), p.654-658

2004

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Beneficial effects of substrate reduction therapy in a mouse model of GM1 gangliosidosis

Molecular genetics and metabolism, 2008-06, Vol.94 (2), p.204-211

2008

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Biosynthesis and signalling functions of central and peripheral nervous system neurosteroids in health and disease

Essays in biochemistry, 2020-09, Vol.64 (3), p.591-606

2020

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On the move, lysosomal CAX drives Ca2+ transport and motility

The Journal of cell biology, 2016-03, Vol.212 (7), p.755-757

Lloyd-Evans, Emyr

2016

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Molecular mechanisms of endolysosomal Ca2+ signalling in health and disease

Biochemical journal, 2011-11, Vol.439 (3), p.349-378

2011

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Lyso-glycosphingolipids mobilize calcium from brain microsomes via multiple mechanisms

Biochemical journal, 2003-11, Vol.375 (Pt 3), p.561-565

2003

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Phosphatidic acid: an emerging versatile class of cellular mediators

Essays in biochemistry, 2020-09, Vol.64 (3), p.533-546

2020

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The lysosomal storage disease continuum with ageing-related neurodegenerative disease

Ageing research reviews, 2016-12, Vol.32, p.104-121

2016

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Lysosomal Ca(2+) homeostasis: role in pathogenesis of lysosomal storage diseases

Cell calcium (Edinburgh), 2011-08, Vol.50 (2), p.200-205

2011

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Presenilin 1 Maintains Lysosomal Ca(2+) Homeostasis via TRPML1 by Regulating vATPase-Mediated Lysosome Acidification

Cell reports (Cambridge), 2015-09, Vol.12 (9), p.1430-1444

2015

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Investigating the Prevalence of Reactive Online Searching in the COVID-19 Pandemic: Infoveillance Study

Journal of medical Internet research, 2020-10, Vol.22 (10), p.e19791

2020

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The role of glycoconjugates as receptors for insecticidal proteins

FEMS microbiology reviews, 2023-07, Vol.47 (4), p.1

2023

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Niemann-Pick disease type C1 is a sphingosine storage disease that causes deregulation of lysosomal calcium

Nature medicine, 2008-11, Vol.14 (11), p.1247-1255

2008

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Lipids on Trial: The Search for the Offending Metabolite in Niemann-Pick type C Disease

PIP2 depletion and altered endocytosis caused by expression of Alzheimer's disease‐protective variant PLCγ2 R522

Endolysosomal calcium regulation and disease

Regulation of TRPML1 function

Unbiased Cell-based Screening in a Neuronal Cell Model of Batten Disease Highlights an Interaction between Ca2+ Homeostasis, Autophagy, and CLN3 Protein Function

A rapid method for the preparation of ultrapure, functional lysosomes using functionalized superparamagnetic iron oxide nanoparticles

The Crystal Structure of Bacillus thuringiensis Tpp80Aa1 and Its Interaction with Galactose-Containing Glycolipids

Compromised astrocyte function and survival negatively impact neurons in infantile neuronal ceroid lipofuscinosis

Enhanced calcium release in the acute neuronopathic form of Gaucher disease

Glucosylceramide and Glucosylsphingosine Modulate Calcium Mobilization from Brain Microsomes via Different Mechanisms

Accumulation of Glycosphingolipids in Niemann-Pick C Disease Disrupts Endosomal Transport

Inhibition of Calcium Uptake via the Sarco/Endoplasmic Reticulum Ca2+-ATPase in a Mouse Model of Sandhoff Disease and Prevention by Treatment with N-Butyldeoxynojirimycin

Treatment with miglustat reverses the lipid-trafficking defect in Niemann–Pick disease type C

Beneficial effects of substrate reduction therapy in a mouse model of GM1 gangliosidosis

Biosynthesis and signalling functions of central and peripheral nervous system neurosteroids in health and disease

On the move, lysosomal CAX drives Ca2+ transport and motility

Molecular mechanisms of endolysosomal Ca2+ signalling in health and disease

Lyso-glycosphingolipids mobilize calcium from brain microsomes via multiple mechanisms

Phosphatidic acid: an emerging versatile class of cellular mediators

The lysosomal storage disease continuum with ageing-related neurodegenerative disease

Lysosomal Ca(2+) homeostasis: role in pathogenesis of lysosomal storage diseases

Presenilin 1 Maintains Lysosomal Ca(2+) Homeostasis via TRPML1 by Regulating vATPase-Mediated Lysosome Acidification

Investigating the Prevalence of Reactive Online Searching in the COVID-19 Pandemic: Infoveillance Study

The role of glycoconjugates as receptors for insecticidal proteins

Niemann-Pick disease type C1 is a sphingosine storage disease that causes deregulation of lysosomal calcium

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