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Targeted anti-mitotic therapies: can we improve on tubulin agents?

Nature reviews. Cancer, 2007-02, Vol.7 (2), p.107-117

2007

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Distinct Concentration-Dependent Effects of the Polo-like Kinase 1―Specific Inhibitor GSK461364A, Including Differential Effect on Apoptosis

Cancer research (Chicago, Ill.), 2009-09, Vol.69 (17), p.6969-6977

2009

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An immune-active tumor microenvironment favors clinical response to ipilimumab

Cancer Immunology, Immunotherapy, 2012-07, Vol.61 (7), p.1019-1031

2012

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The identification and characterization of the marine natural product scytonemin as a novel antiproliferative pharmacophore

The Journal of pharmacology and experimental therapeutics, 2002-11, Vol.303 (2), p.858

2002

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Assessment of association between BRAF-V600E mutation status in melanomas and clinical response to ipilimumab

Cancer Immunology, Immunotherapy, 2012-05, Vol.61 (5), p.733-737

2012

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Antitumor activity of an allosteric inhibitor of centromere-associated protein-E

Proceedings of the National Academy of Sciences - PNAS, 2010-03, Vol.107 (13), p.5839-5844

2010

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Constitutive expression of angiopoietin-1 and -2 and modulation of their expression by inflammatory cytokines in rheumatoid arthritis synovial fibroblasts

Journal of rheumatology, 2002-02, Vol.29 (2), p.230

2002

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Past and future of the mitotic spindle as an oncology target

Current Opinion in Pharmacology, 2001-08, Vol.1 (4), p.370-377

2001

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Novel ATP-Competitive Kinesin Spindle Protein Inhibitors

Journal of medicinal chemistry, 2007-10, Vol.50 (20), p.4939-4952

2007

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ATP-competitive inhibitors of the mitotic kinesin KSP that function via an allosteric mechanism

Nature chemical biology, 2007-11, Vol.3 (11), p.722-726

2007

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Integrated analysis of breast cancer cell lines reveals unique signaling pathways

Genome biology, 2009-03, Vol.10 (3), p.R31-R31

2009

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An indolocarbazole inhibitor of human checkpoint kinase (Chk1) abrogates cell cycle arrest caused by DNA damage

Cancer research (Chicago, Ill.), 2000-02, Vol.60 (3), p.566-572

2000

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Design of potent thiophene inhibitors of polo-like kinase 1 with improved solubility and reduced protein binding

Bioorganic & medicinal chemistry letters, 2009-03, Vol.19 (6), p.1694-1697

2009

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Mechanism of Inhibition of Human KSP by Monastrol: Insights from Kinetic Analysis and the Effect of Ionic Strength on KSP Inhibition

Biochemistry (Easton), 2004-12, Vol.43 (48), p.15258-15266

2004

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Identification of Drosophila Myt1 kinase and its role in Golgi during mitosis

Cellular signalling, 2002-05, Vol.14 (5), p.467-476

2002

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G2 Checkpoint Control: Checking in to the Last Resort for DNA Damage

Cancer biology & therapy, 2004-03, Vol.3 (3), p.314-316

2004

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Heteroaryl-linked 5-(1H-benzimidazol-1-yl)-2-thiophenecarboxamides: Potent inhibitors of polo-like kinase 1 (PLK1) with improved drug-like properties

Bioorganic & medicinal chemistry letters, 2010-08, Vol.20 (15), p.4587-4592

2010

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Conformation-Dependent Ligand Regulation of ATP Hydrolysis by Human KSP: Activation of Basal Hydrolysis and Inhibition of Microtubule-Stimulated Hydrolysis by a Single, Small Molecule Modulator

Journal of the American Chemical Society, 2008-06, Vol.130 (24), p.7584-7591

2008

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Pharmacological effects of SB 220025, a selective inhibitor of P38 mitogen-activated protein kinase, in angiogenesis and chronic inflammatory disease models

The Journal of pharmacology and experimental therapeutics, 1998-02, Vol.284 (2), p.687

1998

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The role of platelet activating factor and other lipid mediators in inflammatory angiogenesis

Biochimica et biophysica acta, 1998-05, Vol.1392 (1), p.145-152

1998

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The codependence of angiogenesis and chronic inflammation

The FASEB journal, 1997-05, Vol.11 (6), p.457-465

1997

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In vitro antibody maturation. Improvement of a high affinity, neutralizing antibody against IL-1 beta

The Journal of immunology (1950), 1995-04, Vol.154 (7), p.3310

1995

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DNA - histone interactions are sufficient to position single nucleosome juxtaposing Drosophila Adh adult enhancer and distal promoter

Nucleic acids research, 1993-02, Vol.21 (4), p.957-967

1993

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Alternative DNA-protein interactions in variable-length internucleosomal regions associated with Drosophila Adh distal promoter expression

Nucleic acids research, 1990-04, Vol.18 (7), p.1771-1781

1990

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A Comparative Effectiveness Meta-Analysis of Drugs for the Prophylaxis of Migraine Headache

PloS one, 2015-07, Vol.10 (7), p.e0130733

2015

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Targeted anti-mitotic therapies: can we improve on tubulin agents?

Distinct Concentration-Dependent Effects of the Polo-like Kinase 1―Specific Inhibitor GSK461364A, Including Differential Effect on Apoptosis

An immune-active tumor microenvironment favors clinical response to ipilimumab

The identification and characterization of the marine natural product scytonemin as a novel antiproliferative pharmacophore

Assessment of association between BRAF-V600E mutation status in melanomas and clinical response to ipilimumab

Antitumor activity of an allosteric inhibitor of centromere-associated protein-E

Constitutive expression of angiopoietin-1 and -2 and modulation of their expression by inflammatory cytokines in rheumatoid arthritis synovial fibroblasts

Past and future of the mitotic spindle as an oncology target

Novel ATP-Competitive Kinesin Spindle Protein Inhibitors

ATP-competitive inhibitors of the mitotic kinesin KSP that function via an allosteric mechanism

Integrated analysis of breast cancer cell lines reveals unique signaling pathways

An indolocarbazole inhibitor of human checkpoint kinase (Chk1) abrogates cell cycle arrest caused by DNA damage

Design of potent thiophene inhibitors of polo-like kinase 1 with improved solubility and reduced protein binding

Mechanism of Inhibition of Human KSP by Monastrol: Insights from Kinetic Analysis and the Effect of Ionic Strength on KSP Inhibition

Identification of Drosophila Myt1 kinase and its role in Golgi during mitosis

G2 Checkpoint Control: Checking in to the Last Resort for DNA Damage

Heteroaryl-linked 5-(1H-benzimidazol-1-yl)-2-thiophenecarboxamides: Potent inhibitors of polo-like kinase 1 (PLK1) with improved drug-like properties

Conformation-Dependent Ligand Regulation of ATP Hydrolysis by Human KSP: Activation of Basal Hydrolysis and Inhibition of Microtubule-Stimulated Hydrolysis by a Single, Small Molecule Modulator

Pharmacological effects of SB 220025, a selective inhibitor of P38 mitogen-activated protein kinase, in angiogenesis and chronic inflammatory disease models

The role of platelet activating factor and other lipid mediators in inflammatory angiogenesis

The codependence of angiogenesis and chronic inflammation

In vitro antibody maturation. Improvement of a high affinity, neutralizing antibody against IL-1 beta

DNA - histone interactions are sufficient to position single nucleosome juxtaposing Drosophila Adh adult enhancer and distal promoter

Alternative DNA-protein interactions in variable-length internucleosomal regions associated with Drosophila Adh distal promoter expression

A Comparative Effectiveness Meta-Analysis of Drugs for the Prophylaxis of Migraine Headache

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