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Novel orally bioavailable EZH1/2 dual inhibitors with greater antitumor efficacy than an EZH2 selective inhibitor

Cancer science, 2017-10, Vol.108 (10), p.2069-2078

2017

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Discovery of novel thieno[2,3- d]pyrimidin-4-yl hydrazone-based inhibitors of Cyclin D1-CDK4: Synthesis, biological evaluation, and structure–activity relationships

Bioorganic & medicinal chemistry letters, 2009-01, Vol.19 (2), p.305-308

2009

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Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway

Nature immunology, 2002-02, Vol.3 (2), p.196-200

2002

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Cutting Edge: Role of Toll-Like Receptor 1 in Mediating Immune Response to Microbial Lipoproteins

The Journal of immunology (1950), 2002-07, Vol.169 (1), p.10-14

2002

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Discovery of Novel Thieno[2,3-d]pyrimidin-4-yl Hydrazone-Based Cyclin-Dependent Kinase 4 Inhibitors: Synthesis, Biological Evaluation and Structure–Activity Relationships

Chemical and Pharmaceutical Bulletin, 2011/08/01, Vol.59(8), pp.991-1002

2011

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Structure–Activity Relationships of 1,3-Benzoxazole-4-carbonitriles as Novel Antifungal Agents with Potent in Vivo Efficacy

Chemical and Pharmaceutical Bulletin, 2011/03/01, Vol.59(3), pp.341-352

2011

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Helicobacter pylori DNA in Drinking Water in Japan

Microbiology and immunology, 2001-01, Vol.45 (7), p.515-519

2001

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Highly potent, orally active novel small-molecule HPK1 inhibitor DS21150768 induces anti-tumor responses in multiple syngeneic tumor mouse models

European journal of pharmacology, 2023-12, Vol.961, p.176184-176184, Article 176184

2023

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Severe Duodenal Hemorrhage Induced by Lugol's Solution Administered for Thyroid Crisis Treatment

Internal Medicine, 2010, Vol.49(8), pp.759-761

2010

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Discovery of novel thieno[2,3- d]pyrimidin-4-yl hydrazone-based inhibitors of Cyclin D1-CDK4: Synthesis, biological evaluation and structure–activity relationships. Part 2

Bioorganic & medicinal chemistry, 2009-12, Vol.17 (23), p.7850-7860

2009

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4-(Pyrrolidinyl)methoxybenzoic Acid Derivatives as a Potent, Orally Active VLA-4 Antagonist

Chemical and Pharmaceutical Bulletin, 2006, Vol.54(11), pp.1515-1529

2006

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1,3-Benzoxazole-4-carbonitrile as a novel antifungal scaffold of β-1,6-glucan synthesis inhibitors

Bioorganic & medicinal chemistry, 2010-11, Vol.18 (21), p.7593-7606

2010

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Disappearance of multiple hyperplastic polyps after eradication of Helicobacter pylori

Gastrointestinal endoscopy, 1997-12, Vol.46 (6), p.566-568

1997

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Construction of a plasmid vector for the regulatable high level expression of eukaryotic genes in Escherichia coli: an application to overproduction of chicken lysozyme

Protein engineering, 1987-08, Vol.1 (4), p.327-332

1987

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Syntheses and Absolute Structures of the Disaccharide and Aglycone of Acaricidal Gualamycin

The Journal of Antibiotics, 1995/07/25, Vol.48(7), pp.741-744

1995

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New highly active taxoids from 9beta-dihydrobaccatin-9,10-acetals. Part 4

Bioorganic & medicinal chemistry, 2003-10, Vol.11 (20), p.4431-4447

2003

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An abdominal follicular dendritic cell tumor in Castleman's disease

Rinshō ketsueki, 2004-09, Vol.45 (9), p.1033

2004

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Changes in serum pepsinogen, gastrin, and immunoglobulin G antibody titers in helicobacter pylori-positive gastric ulcer after eradication of infection

Journal of clinical gastroenterology, 1997-07, Vol.25 (1), p.317-322

1997

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Wilms’ tumor 1-associating protein complex regulates alternative splicing and polyadenylation at potential G-quadruplex-forming splice site sequences

The Journal of biological chemistry, 2021-11, Vol.297 (5), p.101248-101248, Article 101248

2021

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Identification of Wilms' Tumor 1-associating Protein Complex and Its Role in Alternative Splicing and the Cell Cycle

The Journal of biological chemistry, 2013-11, Vol.288 (46), p.33292-33302

2013

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Introduction of sugar-modified nucleotides into CpG-containing antisense oligonucleotides inhibits TLR9 activation

Scientific reports, 2024-05, Vol.14 (1), p.11540-11540, Article 11540

2024

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A genome-wide association study identified AFF1 as a susceptibility locus for systemic lupus eyrthematosus in Japanese

PLoS genetics, 2012-01, Vol.8 (1), p.e1002455-e1002455

2012

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Long‐term outcomes of esophageal squamous cell carcinoma with invasion depth of pathological T1a‐muscularis mucosae and T1b‐submucosa by endoscopic resection followed by appropriate additional treatment

Digestive endoscopy, 2022-05, Vol.34 (4), p.793-804

2022

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Synthesis of natural product-like polyprenylated phenols and quinones: Evaluation of their neuroprotective activities

Bioorganic & medicinal chemistry, 2020-01, Vol.28 (1), p.115156, Article 115156

2020

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Diagnostic and prognostic biomarkers for progressive fibrosing interstitial lung disease

PloS one, 2023-03, Vol.18 (3), p.e0283288-e0283288

2023

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Novel orally bioavailable EZH1/2 dual inhibitors with greater antitumor efficacy than an EZH2 selective inhibitor

Discovery of novel thieno[2,3- d]pyrimidin-4-yl hydrazone-based inhibitors of Cyclin D1-CDK4: Synthesis, biological evaluation, and structure–activity relationships

Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway

Cutting Edge: Role of Toll-Like Receptor 1 in Mediating Immune Response to Microbial Lipoproteins

Discovery of Novel Thieno[2,3-d]pyrimidin-4-yl Hydrazone-Based Cyclin-Dependent Kinase 4 Inhibitors: Synthesis, Biological Evaluation and Structure–Activity Relationships

Structure–Activity Relationships of 1,3-Benzoxazole-4-carbonitriles as Novel Antifungal Agents with Potent in Vivo Efficacy

Helicobacter pylori DNA in Drinking Water in Japan

Highly potent, orally active novel small-molecule HPK1 inhibitor DS21150768 induces anti-tumor responses in multiple syngeneic tumor mouse models

Severe Duodenal Hemorrhage Induced by Lugol's Solution Administered for Thyroid Crisis Treatment

Discovery of novel thieno[2,3- d]pyrimidin-4-yl hydrazone-based inhibitors of Cyclin D1-CDK4: Synthesis, biological evaluation and structure–activity relationships. Part 2

4-(Pyrrolidinyl)methoxybenzoic Acid Derivatives as a Potent, Orally Active VLA-4 Antagonist

1,3-Benzoxazole-4-carbonitrile as a novel antifungal scaffold of β-1,6-glucan synthesis inhibitors

Disappearance of multiple hyperplastic polyps after eradication of Helicobacter pylori

Construction of a plasmid vector for the regulatable high level expression of eukaryotic genes in Escherichia coli: an application to overproduction of chicken lysozyme

Syntheses and Absolute Structures of the Disaccharide and Aglycone of Acaricidal Gualamycin

New highly active taxoids from 9beta-dihydrobaccatin-9,10-acetals. Part 4

An abdominal follicular dendritic cell tumor in Castleman's disease

Changes in serum pepsinogen, gastrin, and immunoglobulin G antibody titers in helicobacter pylori-positive gastric ulcer after eradication of infection

Wilms’ tumor 1-associating protein complex regulates alternative splicing and polyadenylation at potential G-quadruplex-forming splice site sequences

Identification of Wilms' Tumor 1-associating Protein Complex and Its Role in Alternative Splicing and the Cell Cycle

Introduction of sugar-modified nucleotides into CpG-containing antisense oligonucleotides inhibits TLR9 activation

A genome-wide association study identified AFF1 as a susceptibility locus for systemic lupus eyrthematosus in Japanese

Long‐term outcomes of esophageal squamous cell carcinoma with invasion depth of pathological T1a‐muscularis mucosae and T1b‐submucosa by endoscopic resection followed by appropriate additional treatment

Synthesis of natural product-like polyprenylated phenols and quinones: Evaluation of their neuroprotective activities

Diagnostic and prognostic biomarkers for progressive fibrosing interstitial lung disease

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