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SUMO1 degrader induces ER stress and ROS accumulation through deSUMOylation of TCF4 and inhibition of its transcription of StarD7 in colon cancer

Molecular carcinogenesis, 2023-09, Vol.62 (9), p.1249-1262

2023

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Ubiquitination and degradation of SUMO1 by small-molecule degraders extends survival of mice with patient-derived tumors

Science translational medicine, 2021-10, Vol.13 (615), p.eabh1486

2021

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Substituted pyrazoles as novel sEH antagonist: Investigation of key binding interactions within the catalytic domain

Bioorganic & medicinal chemistry letters, 2010-11, Vol.20 (22), p.6379-6383

2010

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Itk inhibitors: a patent review

Expert opinion on therapeutic patents, 2010-04, Vol.20 (4), p.459-469

Lo, Ho Yin

2010

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Benzimidazolone as potent chymase inhibitor: Modulation of reactive metabolite formation in the hydrophobic (P 1) region

Bioorganic & medicinal chemistry letters, 2011-08, Vol.21 (15), p.4533-4539

2011

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Discovery, SAR and X-ray structure of 1H-benzimidazole-5-carboxylic acid cyclohexyl-methyl-amides as inhibitors of inducible T-cell kinase (Itk)

Bioorganic & medicinal chemistry, 2008-10, Vol.18 (20), p.5545-5549

2008

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Synthesis, SAR, and Series Evolution of Novel Oxadiazole-Containing 5‑Lipoxygenase Activating Protein Inhibitors: Discovery of 2‑[4-(3-{(R)‑1-[4-(2-Amino-pyrimidin-5-yl)-phenyl]-1-cyclopropyl-ethyl}-[1,2,4]oxadiazol-5-yl)-pyrazol-1-yl]‑N,N‑dimethyl-acetamide (BI 665915)

Journal of medicinal chemistry, 2015-02, Vol.58 (4), p.1669-1690

2015

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Chemical Modification of a Highly Functionalized Taxane. The Consequences of an Absent Bridgehead Double Bond on Oxetane D-Ring Construction

Journal of organic chemistry, 2003-03, Vol.68 (6), p.2282-2289

2003

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2-Aminobenzimidazoles as potent ITK antagonists: trans-stilbene-like moieties targeting the kinase specificity pocket

Bioorganic & medicinal chemistry, 2008-12, Vol.18 (23), p.6218-6221

2008

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A delicate balance of energetics. Subtleties associated with alpha-ketol-based bridge migration to afford 9-keto-10beta-p-methoxybenzyloxytaxanes

Journal of organic chemistry, 2003-03, Vol.68 (6), p.2276-2281

2003

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Stereospecific Anionically Promoted Transannular Hydride Shifts in Medium-Ring Hydroxy Ketones. Probe of Their Reversibility and the Potential for Regiocontrol

Organic letters, 2001-05, Vol.3 (11), p.1777-1780

2001

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Echocardiographic mapping of left ventricular resynchronization during cardiac resynchronization therapy procedures

Chinese medical journal, 2010-07, Vol.123 (13), p.1645-1651

2010

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Frequency and Distribution of Chest Radiographic Findings in Patients Positive for COVID-19

Radiology, 2020-08, Vol.296 (2), p.E72-E78

2020

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CTNNB1‐related neurodevelopmental disorder in a Chinese population: A case series

American journal of medical genetics. Part A, 2022-01, Vol.188 (1), p.130-137

2022

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Prospective Study of Stereotactic Body Radiation Therapy for Hepatocellular Carcinoma on Waitlist for Liver Transplant

Hepatology (Baltimore, Md.), 2021-11, Vol.74 (5), p.2580-2594

2021

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CCL5 promotion of bioenergy metabolism is crucial for hippocampal synapse complex and memory formation

Molecular psychiatry, 2021-11, Vol.26 (11), p.6451-6468

2021

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Organoid cultures of early-onset colorectal cancers reveal distinct and rare genetic profiles

Gut, 2020-12, Vol.69 (12), p.2165-2179

2020

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Sleep and Academic Performance in Hong Kong Adolescents

The Journal of school health, 2012-11, Vol.82 (11), p.522-527

2012

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Machine learning application for the prediction of SARS-CoV-2 infection using blood tests and chest radiograph

Scientific reports, 2021-07, Vol.11 (1), p.14250-14250, Article 14250

2021

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QRS Fragmentation in Preserved Ejection Fraction Heart Failure: Functional Insights, Pathological Correlates, and Prognosis

Journal of the American Heart Association, 2023-03, Vol.12 (6), p.e028105-e028105

2023

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Sectoral cancer detection and tolerability of freehand transperineal prostate biopsy under local anaesthesia

Prostate cancer and prostatic diseases, 2021-06, Vol.24 (2), p.431-438

2021

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Switching of pyruvate kinase isoform L to M2 promotes metabolic reprogramming in hepatocarcinogenesis

PloS one, 2014-12, Vol.9 (12), p.e115036-e115036

2014

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Mowat–Wilson syndrome in a Chinese population: A case series

American journal of medical genetics. Part A, 2020-06, Vol.182 (6), p.1336-1341

2020

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Recombinant Bacillus caldovelox Arginase Mutant (BCA-M) Induces Apoptosis, Autophagy, Cell Cycle Arrest and Growth Inhibition in Human Cervical Cancer Cells

International journal of molecular sciences, 2020-10, Vol.21 (20), p.7445

2020

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LRRK2, GBA and their interaction in the regulation of autophagy: implications on therapeutics in Parkinson's disease

Translational neurodegeneration, 2022-01, Vol.11 (1), p.5-5, Article 5

2022

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SUMO1 degrader induces ER stress and ROS accumulation through deSUMOylation of TCF4 and inhibition of its transcription of StarD7 in colon cancer

Ubiquitination and degradation of SUMO1 by small-molecule degraders extends survival of mice with patient-derived tumors

Substituted pyrazoles as novel sEH antagonist: Investigation of key binding interactions within the catalytic domain

Itk inhibitors: a patent review

Benzimidazolone as potent chymase inhibitor: Modulation of reactive metabolite formation in the hydrophobic (P 1) region

Discovery, SAR and X-ray structure of 1H-benzimidazole-5-carboxylic acid cyclohexyl-methyl-amides as inhibitors of inducible T-cell kinase (Itk)

Synthesis, SAR, and Series Evolution of Novel Oxadiazole-Containing 5‑Lipoxygenase Activating Protein Inhibitors: Discovery of 2‑[4-(3-{(R)‑1-[4-(2-Amino-pyrimidin-5-yl)-phenyl]-1-cyclopropyl-ethyl}-[1,2,4]oxadiazol-5-yl)-pyrazol-1-yl]‑N,N‑dimethyl-acetamide (BI 665915)

Chemical Modification of a Highly Functionalized Taxane. The Consequences of an Absent Bridgehead Double Bond on Oxetane D-Ring Construction

2-Aminobenzimidazoles as potent ITK antagonists: trans-stilbene-like moieties targeting the kinase specificity pocket

A delicate balance of energetics. Subtleties associated with alpha-ketol-based bridge migration to afford 9-keto-10beta-p-methoxybenzyloxytaxanes

Stereospecific Anionically Promoted Transannular Hydride Shifts in Medium-Ring Hydroxy Ketones. Probe of Their Reversibility and the Potential for Regiocontrol

Echocardiographic mapping of left ventricular resynchronization during cardiac resynchronization therapy procedures

Frequency and Distribution of Chest Radiographic Findings in Patients Positive for COVID-19

CTNNB1‐related neurodevelopmental disorder in a Chinese population: A case series

Prospective Study of Stereotactic Body Radiation Therapy for Hepatocellular Carcinoma on Waitlist for Liver Transplant

CCL5 promotion of bioenergy metabolism is crucial for hippocampal synapse complex and memory formation

Organoid cultures of early-onset colorectal cancers reveal distinct and rare genetic profiles

Sleep and Academic Performance in Hong Kong Adolescents

Machine learning application for the prediction of SARS-CoV-2 infection using blood tests and chest radiograph

QRS Fragmentation in Preserved Ejection Fraction Heart Failure: Functional Insights, Pathological Correlates, and Prognosis

Sectoral cancer detection and tolerability of freehand transperineal prostate biopsy under local anaesthesia

Switching of pyruvate kinase isoform L to M2 promotes metabolic reprogramming in hepatocarcinogenesis

Mowat–Wilson syndrome in a Chinese population: A case series

Recombinant Bacillus caldovelox Arginase Mutant (BCA-M) Induces Apoptosis, Autophagy, Cell Cycle Arrest and Growth Inhibition in Human Cervical Cancer Cells

LRRK2, GBA and their interaction in the regulation of autophagy: implications on therapeutics in Parkinson's disease

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