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Radiation-induced acid ceramidase confers prostate cancer resistance and tumor relapse

The Journal of clinical investigation, 2013-10, Vol.123 (10), p.4344-4358

2013

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Neoplastic and nonneoplastic lesions in aging mice of unique and common inbred strains contribution to modeling of human neoplastic diseases

Veterinary pathology, 2014-05, Vol.51 (3), p.663

2014

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The Human FA2H Gene Encodes a Fatty Acid 2-Hydroxylase

The Journal of biological chemistry, 2004-11, Vol.279 (47), p.48562-48568

2004

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Ceramide is involved in triggering of cardiomyocyte apoptosis induced by ischemia and reperfusion

The American journal of pathology, 1997-11, Vol.151 (5), p.1257-1263

1997

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Ceramide 1-Phosphate Is a Direct Activator of Cytosolic Phospholipase A2

The Journal of biological chemistry, 2004-03, Vol.279 (12), p.11320-11326

2004

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Oxidative Stress Markers and Severity of Obstructive Sleep Apnea

Advances in experimental medicine and biology, 2019, Vol.1222, p.27-35

2019

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Acid Ceramidase Upregulation in Prostate Cancer Cells Confers Resistance to Radiation: AC Inhibition, a Potential Radiosensitizer

Molecular therapy, 2009-03, Vol.17 (3), p.430-438

2009

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Induction of apoptotic cell death and prevention of tumor growth by ceramide analogues in metastatic human colon cancer

Cancer research (Chicago, Ill.), 2001-02, Vol.61 (3), p.1233-1240

2001

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Ceramide Generated by Sphingomyelin Hydrolysis and the Salvage Pathway Is Involved in Hypoxia/Reoxygenation-induced Bax Redistribution to Mitochondria in NT-2 Cells

The Journal of biological chemistry, 2008-09, Vol.283 (39), p.26509-26517

2008

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The ceramide analog, B13, induces apoptosis in prostate cancer cell lines and inhibits tumor growth in prostate cancer xenografts

The Prostate, 2004-03, Vol.58 (4), p.382-393

2004

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Acid ceramidase upregulation in prostate cancer: role in tumor development and implications for therapy

Expert opinion on therapeutic targets, 2009-12, Vol.13 (12), p.1449-1458

2009

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Sphingosine Kinase 1 (SPHK1) Is Induced by Transforming Growth Factor-β and Mediates TIMP-1 Up-regulation

The Journal of biological chemistry, 2004-12, Vol.279 (52), p.53994-54001

2004

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Modulation of Ceramide Metabolism Enhances Viral Protein Apoptin's Cytotoxicity in Prostate Cancer

Molecular therapy, 2006-11, Vol.14 (5), p.637-646

2006

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Role of Acid Ceramidase in Resistance to FasL: Therapeutic Approaches Based on Acid Ceramidase Inhibitors and FasL Gene Therapy

Molecular therapy, 2007-07, Vol.15 (7), p.1259-1263

2007

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Bax and Bcl-xL exert their regulation on different sites of the ceramide channel

Biochemical journal, 2012-07, Vol.445 (1), p.81-91

2012

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Identification of ISC1 (YER019w) as inositol phosphosphingolipid phospholipase C in Saccharomyces cerevisiae

The Journal of biological chemistry, 2000-12, Vol.275 (50), p.39793-39798

2000

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Cloning and characterization of a novel human alkaline ceramidase. A mammalian enzyme that hydrolyzes phytoceramide

The Journal of biological chemistry, 2001-07, Vol.276 (28), p.26577-26588

2001

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Selectivity of ceramide-mediated biology. Lack of activity of erythro-dihydroceramide

The Journal of biological chemistry, 1993-12, Vol.268 (35), p.26226-26232

1993

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Cloning and characterization of a mouse endoplasmic reticulum alkaline ceramidase: an enzyme that preferentially regulates metabolism of very long chain ceramides

The Journal of biological chemistry, 2003-08, Vol.278 (33), p.31184-31191

2003

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Lysosomotropic acid ceramidase inhibitor induces apoptosis in prostate cancer cells

Cancer chemotherapy and pharmacology, 2008-02, Vol.61 (2), p.231-242

2008

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Combining anticancer agents photodynamic therapy and LCL85 leads to distinct changes in the sphingolipid profile, autophagy, caspase-3 activation in the absence of cell death, and long-term sensitization

Biochemical and biophysical research communications, 2011-06, Vol.409 (3), p.372-377

2011

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Anti-ceramidase LCL385 acutely reduces BCL-2 expression in the hippocampus but is not associated with an increase of learned helplessness in rats

Behavioural brain research, 2009-01, Vol.197 (1), p.41-44

2009

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Biochemical characterization of the reverse activity of rat brain ceramidase. A CoA-independent and fumonisin B1-insensitive ceramide synthase

The Journal of biological chemistry, 2001-05, Vol.276 (20), p.16758

2001

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Acid ceramidase inhibition: a novel target for cancer therapy

Frontiers in bioscience, 2008-01, Vol.13, p.2293

2008

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Involvement of Sphingolipids in Apoptin-Induced Cell Killing

Molecular therapy, 2006-11, Vol.14 (5), p.627-636

2006

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Radiation-induced acid ceramidase confers prostate cancer resistance and tumor relapse

Neoplastic and nonneoplastic lesions in aging mice of unique and common inbred strains contribution to modeling of human neoplastic diseases

The Human FA2H Gene Encodes a Fatty Acid 2-Hydroxylase

Ceramide is involved in triggering of cardiomyocyte apoptosis induced by ischemia and reperfusion

Ceramide 1-Phosphate Is a Direct Activator of Cytosolic Phospholipase A2

Oxidative Stress Markers and Severity of Obstructive Sleep Apnea

Acid Ceramidase Upregulation in Prostate Cancer Cells Confers Resistance to Radiation: AC Inhibition, a Potential Radiosensitizer

Induction of apoptotic cell death and prevention of tumor growth by ceramide analogues in metastatic human colon cancer

Ceramide Generated by Sphingomyelin Hydrolysis and the Salvage Pathway Is Involved in Hypoxia/Reoxygenation-induced Bax Redistribution to Mitochondria in NT-2 Cells

The ceramide analog, B13, induces apoptosis in prostate cancer cell lines and inhibits tumor growth in prostate cancer xenografts

Acid ceramidase upregulation in prostate cancer: role in tumor development and implications for therapy

Sphingosine Kinase 1 (SPHK1) Is Induced by Transforming Growth Factor-β and Mediates TIMP-1 Up-regulation

Modulation of Ceramide Metabolism Enhances Viral Protein Apoptin's Cytotoxicity in Prostate Cancer

Role of Acid Ceramidase in Resistance to FasL: Therapeutic Approaches Based on Acid Ceramidase Inhibitors and FasL Gene Therapy

Bax and Bcl-xL exert their regulation on different sites of the ceramide channel

Identification of ISC1 (YER019w) as inositol phosphosphingolipid phospholipase C in Saccharomyces cerevisiae

Cloning and characterization of a novel human alkaline ceramidase. A mammalian enzyme that hydrolyzes phytoceramide

Selectivity of ceramide-mediated biology. Lack of activity of erythro-dihydroceramide

Cloning and characterization of a mouse endoplasmic reticulum alkaline ceramidase: an enzyme that preferentially regulates metabolism of very long chain ceramides

Lysosomotropic acid ceramidase inhibitor induces apoptosis in prostate cancer cells

Combining anticancer agents photodynamic therapy and LCL85 leads to distinct changes in the sphingolipid profile, autophagy, caspase-3 activation in the absence of cell death, and long-term sensitization

Anti-ceramidase LCL385 acutely reduces BCL-2 expression in the hippocampus but is not associated with an increase of learned helplessness in rats

Biochemical characterization of the reverse activity of rat brain ceramidase. A CoA-independent and fumonisin B1-insensitive ceramide synthase

Acid ceramidase inhibition: a novel target for cancer therapy

Involvement of Sphingolipids in Apoptin-Induced Cell Killing

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