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Seven transmembrane receptors: something old, something new

Acta Physiologica, 2007-05, Vol.190 (1), p.9-19

Lefkowitz, R.J

2007

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Enhanced Morphine Analgesia in Mice Lacking β-Arrestin 2

Science (American Association for the Advancement of Science), 1999-12, Vol.286 (5449), p.2495-2498

1999

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Desensitization of G protein-coupled receptors and neuronal functions

Annual review of neuroscience, 2004-01, Vol.27 (1), p.107-144

2004

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β-Arrestin 2: A Receptor-Regulated MAPK Scaffold for the Activation of JNK3

Science (American Association for the Advancement of Science), 2000-11, Vol.290 (5496), p.1574-1577

2000

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G protein—coupled receptor kinases

Cell, 1993-08, Vol.74 (3), p.409-412

Lefkowitz, Robert J.

1993

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Constitutive activity of receptors coupled to guanine nucleotide regulatory proteins

Trends in pharmacological sciences (Regular ed.), 1993-08, Vol.14 (8), p.303-307

1993

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Cardiac Function in Mice Overexpressing the β-Adrenergic Receptor Kinase or a βARK Inhibitor

Science (American Association for the Advancement of Science), 1995-06, Vol.268 (5215), p.1350-1353

1995

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Reciprocal in vivo regulation of myocardial G protein-coupled receptor kinase expression by β-adrenergic receptor stimulation and blockade

Circulation (New York, N.Y.), 1998-10, Vol.98 (17), p.1783-1789

1998

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Beta-adrenergic receptor sequestration. A potential mechanism of receptor resensitization

The Journal of biological chemistry, 1993-01, Vol.268 (1), p.337-341

1993

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Inhibition of thrombin receptor signaling by a G-protein coupled receptor kinase. Functional specificity among G-protein coupled receptor kinases

The Journal of biological chemistry, 1994-01, Vol.269 (2), p.1125-1130

1994

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Structure and mechanism of the G protein-coupled receptor kinases

The Journal of biological chemistry, 1993-11, Vol.268 (32), p.23735-23738

1993

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Beta-arrestin2, a novel member of the arrestin/beta-arrestin gene family

The Journal of biological chemistry, 1992-09, Vol.267 (25), p.17882-17890

1992

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Identification, purification, and characterization of GRK5, a member of the family of G protein-coupled receptor kinases

The Journal of biological chemistry, 1994-03, Vol.269 (9), p.6832-6841

1994

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Turning off the signal: desensitization of β‐adrenergic receptor function

The FASEB journal, 1990-08, Vol.4 (11), p.2881-2889

1990

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μ-Opioid receptor desensitization by β-arrestin-2 determines morphine tolerance but not dependence

Nature (London), 2000-12, Vol.408 (6813), p.720-723

2000

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Regulation of G Protein–Coupled Receptor Signaling by Scaffold Proteins

Circulation research, 2002-10, Vol.91 (8), p.672-680

2002

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Hybrid Transgenic Mice Reveal In Vivo Specificity of G Protein–Coupled Receptor Kinases in the Heart

Circulation research, 2000-01, Vol.86 (1), p.43-43

2000

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Effector Coupling Mechanisms of the Cloned 5-HT1A Receptor

The Journal of biological chemistry, 1989-09, Vol.264 (25), p.14848-14852

1989

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Dishevelled 2 Recruits β-Arrestin 2 to Mediate Wnt5A-Stimulated Endocytosis of Frizzled 4

Science (American Association for the Advancement of Science), 2003-09, Vol.301 (5638), p.1391-1394

2003

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Isoprenylation in regulation of signal transduction by G-protein-coupled receptor kinases

Nature (London), 1992-09, Vol.359 (6391), p.147-150

1992

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Molecular Mechanism of β-Arrestin-Biased Agonism at Seven-Transmembrane Receptors

Annual review of pharmacology and toxicology, 2012-01, Vol.52 (1), p.179-197

2012

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β -adrenergic Receptor Kinase: Identification of a Novel Protein Kinase That Phosphorylates the Agonist-Occupied Form of the Receptor

Proceedings of the National Academy of Sciences - PNAS, 1986-05, Vol.83 (9), p.2797-2801

1986

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Functional Desensitization of the Isolated β -adrenergic Receptor by the β -adrenergic Receptor Kinase: Potential Role of an Analog of the Retinal Protein Arrestin (48-kDa Protein)

Proceedings of the National Academy of Sciences - PNAS, 1987-12, Vol.84 (24), p.8879-8882

1987

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In vivo inhibition of elevated myocardial β-adrenergic receptor kinase activity in hybrid transgenic mice restores normal β-adrenergic signaling and function

Circulation (New York, N.Y.), 1999-08, Vol.100 (6), p.648-653

1999

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Isoprenylation of a protein kinase. Requirement of farnesylation/alpha-carboxyl methylation for full enzymatic activity of rhodopsin kinase

The Journal of biological chemistry, 1992-01, Vol.267 (3), p.1422-1425

1992

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Seven transmembrane receptors: something old, something new

Enhanced Morphine Analgesia in Mice Lacking β-Arrestin 2

Desensitization of G protein-coupled receptors and neuronal functions

β-Arrestin 2: A Receptor-Regulated MAPK Scaffold for the Activation of JNK3

G protein—coupled receptor kinases

Constitutive activity of receptors coupled to guanine nucleotide regulatory proteins

Cardiac Function in Mice Overexpressing the β-Adrenergic Receptor Kinase or a βARK Inhibitor

Reciprocal in vivo regulation of myocardial G protein-coupled receptor kinase expression by β-adrenergic receptor stimulation and blockade

Beta-adrenergic receptor sequestration. A potential mechanism of receptor resensitization

Inhibition of thrombin receptor signaling by a G-protein coupled receptor kinase. Functional specificity among G-protein coupled receptor kinases

Structure and mechanism of the G protein-coupled receptor kinases

Beta-arrestin2, a novel member of the arrestin/beta-arrestin gene family

Identification, purification, and characterization of GRK5, a member of the family of G protein-coupled receptor kinases

Turning off the signal: desensitization of β‐adrenergic receptor function

μ-Opioid receptor desensitization by β-arrestin-2 determines morphine tolerance but not dependence

Regulation of G Protein–Coupled Receptor Signaling by Scaffold Proteins

Hybrid Transgenic Mice Reveal In Vivo Specificity of G Protein–Coupled Receptor Kinases in the Heart

Effector Coupling Mechanisms of the Cloned 5-HT1A Receptor

Dishevelled 2 Recruits β-Arrestin 2 to Mediate Wnt5A-Stimulated Endocytosis of Frizzled 4

Isoprenylation in regulation of signal transduction by G-protein-coupled receptor kinases

Molecular Mechanism of β-Arrestin-Biased Agonism at Seven-Transmembrane Receptors

β -adrenergic Receptor Kinase: Identification of a Novel Protein Kinase That Phosphorylates the Agonist-Occupied Form of the Receptor

Functional Desensitization of the Isolated β -adrenergic Receptor by the β -adrenergic Receptor Kinase: Potential Role of an Analog of the Retinal Protein Arrestin (48-kDa Protein)

In vivo inhibition of elevated myocardial β-adrenergic receptor kinase activity in hybrid transgenic mice restores normal β-adrenergic signaling and function

Isoprenylation of a protein kinase. Requirement of farnesylation/alpha-carboxyl methylation for full enzymatic activity of rhodopsin kinase

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