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Huntington's disease alters human neurodevelopment

Science (American Association for the Advancement of Science), 2020-08, Vol.369 (6505), p.787-793

2020

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Vasohibins/SVBP are tubulin carboxypeptidases (TCPs) that regulate neuron differentiation

Science (American Association for the Advancement of Science), 2017-12, Vol.358 (6369), p.1448-1453

2017

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Phosphorylation of mutant huntingtin at S421 restores anterograde and retrograde transport in neurons

Human molecular genetics, 2008-12, Vol.17 (24), p.3837-3846

2008

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Serine 421 regulates mutant huntingtin toxicity and clearance in mice

The Journal of clinical investigation, 2016-09, Vol.126 (9), p.3585-3597

2016

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The striatal kinase DCLK3 produces neuroprotection against mutant huntingtin

Brain (London, England : 1878), 2018-05, Vol.141 (5), p.1434-1454

2018

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Mitogen- and stress-activated protein kinase-1 deficiency is involved in expanded-huntingtin-induced transcriptional dysregulation and striatal death

The FASEB journal, 2008-04, Vol.22 (4), p.1083-1093

2008

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Akt is altered in an animal model of Huntington's disease and in patients

The European journal of neuroscience, 2005-03, Vol.21 (6), p.1478-1488

2005

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The serum- and glucocorticoid-induced kinase SGK inhibits mutant huntingtin-induced toxicity by phosphorylating serine 421 of huntingtin

The European journal of neuroscience, 2004-01, Vol.19 (2), p.273-279

2004

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B44 Huntingtin regulates cortical development: consequences for huntington’s disease

Journal of neurology, neurosurgery and psychiatry, 2016-09, Vol.87 (Suppl 1), p.A24-A25

2016

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Longitudinal multimodal MRI characterization of a knock-in mouse model of Huntington’s disease reveals early gray and white matter alterations

Human molecular genetics, 2022-11, Vol.31 (21), p.3581-3596

2022

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Longitudinal multimodal MRI characterization of a knock-in mouse model of Huntington’s disease reveals early gray and white matter alterations

Human molecular genetics, 2022-11, Vol.31 (21), p.3581-3596

2022

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DNA Repair Helicase: A Component of BTF2 (TFIIH) Basic Transcription Factor

Science (American Association for the Advancement of Science), 1993-04, Vol.260 (5104), p.58-63

1993

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Longitudinal multimodal MRI characterization of a knock-in mouse model of Huntington's disease reveals early gray and white matter alterations

Human molecular genetics, 2022-10, Vol.31 (21), p.3581-3596

2022

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Treating early postnatal circuit defect delays Huntington's disease onset and pathology in mice

Science (American Association for the Advancement of Science), 2022-09, Vol.377 (6613), p.eabq5011-eabq5011

2022

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A phase II, open-label evaluation of cysteamine tolerability in patients with Huntington's disease

Movement disorders, 2015-02, Vol.30 (2), p.288-289

2015

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Calcineurin and huntingtin form a calcium-sensing machinery that directs neurotrophic signals to the nucleus

Science advances, 2022-01, Vol.8 (1), p.eabj8812-eabj8812

2022

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Increasing brain palmitoylation rescues behavior and neuropathology in Huntington disease mice

Science advances, 2021-03, Vol.7 (14)

2021

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Altered cholesterol homeostasis contributes to enhanced excitotoxicity in Huntington's disease

Journal of neurochemistry, 2010-10, Vol.115 (1), p.153-167

2010

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IGF-1 Intranasal Administration Rescues Huntington's Disease Phenotypes in YAC128 Mice

Molecular neurobiology, 2014-06, Vol.49 (3), p.1126-1142

2014

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Low cancer prevalence in polyglutamine expansion diseases

Neurology, 2017-03, Vol.88 (12), p.1114-1119

2017

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Activation of IGF-1 and Insulin Signaling Pathways Ameliorate Mitochondrial Function and Energy Metabolism in Huntington’s Disease Human Lymphoblasts

Molecular neurobiology, 2015-02, Vol.51 (1), p.331-348

2015

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Unraveling the Role of Huntingtin in Breast Cancer Metastasis

JNCI : Journal of the National Cancer Institute, 2015-10, Vol.107 (10), p.djv208

2015

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Cystamine and cysteamine increase brain levels of BDNF in Huntington disease via HSJ1b and transglutaminase

The Journal of clinical investigation, 2006-05, Vol.116 (5), p.1410-1424

2006

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MB-18POST-TRANSLATIONAL REGULATION OF ATOH1: FROM CEREBELLAR DEVELOPMENT TO MEDULLOBLASTOMA FORMATION

Neuro-oncology (Charlottesville, Va.), 2015-04, Vol.17 (Suppl 3), p.iii23-iii23

2015

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Unraveling the Role of Huntingtin in Breast Cancer Metastasis

JNCI : Journal of the National Cancer Institute, 2015-10, Vol.107 (10), p.1

2015

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Huntington's disease alters human neurodevelopment

Vasohibins/SVBP are tubulin carboxypeptidases (TCPs) that regulate neuron differentiation

Phosphorylation of mutant huntingtin at S421 restores anterograde and retrograde transport in neurons

Serine 421 regulates mutant huntingtin toxicity and clearance in mice

The striatal kinase DCLK3 produces neuroprotection against mutant huntingtin

Mitogen- and stress-activated protein kinase-1 deficiency is involved in expanded-huntingtin-induced transcriptional dysregulation and striatal death

Akt is altered in an animal model of Huntington's disease and in patients

The serum- and glucocorticoid-induced kinase SGK inhibits mutant huntingtin-induced toxicity by phosphorylating serine 421 of huntingtin

B44 Huntingtin regulates cortical development: consequences for huntington’s disease

Longitudinal multimodal MRI characterization of a knock-in mouse model of Huntington’s disease reveals early gray and white matter alterations

Longitudinal multimodal MRI characterization of a knock-in mouse model of Huntington’s disease reveals early gray and white matter alterations

DNA Repair Helicase: A Component of BTF2 (TFIIH) Basic Transcription Factor

Longitudinal multimodal MRI characterization of a knock-in mouse model of Huntington's disease reveals early gray and white matter alterations

Treating early postnatal circuit defect delays Huntington's disease onset and pathology in mice

A phase II, open-label evaluation of cysteamine tolerability in patients with Huntington's disease

Calcineurin and huntingtin form a calcium-sensing machinery that directs neurotrophic signals to the nucleus

Increasing brain palmitoylation rescues behavior and neuropathology in Huntington disease mice

Altered cholesterol homeostasis contributes to enhanced excitotoxicity in Huntington's disease

IGF-1 Intranasal Administration Rescues Huntington's Disease Phenotypes in YAC128 Mice

Low cancer prevalence in polyglutamine expansion diseases

Activation of IGF-1 and Insulin Signaling Pathways Ameliorate Mitochondrial Function and Energy Metabolism in Huntington’s Disease Human Lymphoblasts

Unraveling the Role of Huntingtin in Breast Cancer Metastasis

Cystamine and cysteamine increase brain levels of BDNF in Huntington disease via HSJ1b and transglutaminase

MB-18POST-TRANSLATIONAL REGULATION OF ATOH1: FROM CEREBELLAR DEVELOPMENT TO MEDULLOBLASTOMA FORMATION

Unraveling the Role of Huntingtin in Breast Cancer Metastasis

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