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The application of targeted protein degradation technologies to G protein‐coupled receptors

British journal of pharmacology, 2024-07, Vol.181 (14), p.2351-2358

2024

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Signal transduction pathways activated by insulin‐like peptide 5 at the relaxin family peptide RXFP4 receptor

British journal of pharmacology, 2017-05, Vol.174 (10), p.1077-1089

2017

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Adenylyl cyclase signalling complexes - Pharmacological challenges and opportunities

Pharmacology & therapeutics (Oxford), 2017-04, Vol.172, p.171-180

2017

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Signalling in response to sub‐picomolar concentrations of active compounds: Pushing the boundaries of GPCR sensitivity

British journal of pharmacology, 2019-07, Vol.176 (14), p.2382-2401

2019

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Pathological changes in GPCR signal organisation: Opportunities for targeted therapies for triple negative breast cancer

Pharmacology & therapeutics (Oxford), 2023-01, Vol.241, p.108331-108331, Article 108331

2023

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Glucagon-like peptide-1 receptor internalisation controls spatiotemporal signalling mediated by biased agonists

Biochemical pharmacology, 2018-10, Vol.156, p.406-419

2018

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The β2‐adrenoceptor activates a positive cAMP‐calcium feedforward loop to drive breast cancer cell invasion

The FASEB journal, 2016-03, Vol.30 (3), p.1144-1154

2016

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Constitutive formation of an RXFP1‐signalosome: a novel paradigm in GPCR function and regulation

British journal of pharmacology, 2012-03, Vol.165 (6), p.1644-1658

Halls, Michelle L

2012

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The application of artificial intelligence to accelerate G protein‐coupled receptor drug discovery

British journal of pharmacology, 2024-07, Vol.181 (14), p.2371-2384

2024

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LYCHOS is a human hybrid of a plant-like PIN transporter and a GPCR

Nature (London), 2024-10

2024

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Relaxin inhibits renal myofibroblast differentiation via RXFP1, the nitric oxide pathway, and Smad2

The FASEB journal, 2009-04, Vol.23 (4), p.1219-1229

2009

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Relaxin Activates Multiple cAMP Signaling Pathway Profiles in Different Target Cells

Annals of the New York Academy of Sciences, 2009-04, Vol.1160 (1), p.108-111

2009

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Roles of the Receptor, the Ligand, and the Cell in the Signal Transduction Pathways Utilized by the Relaxin Family Peptide Receptors 1-3

Annals of the New York Academy of Sciences, 2009-04, Vol.1160 (1), p.99-104

2009

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Investigations into the Inhibitory Effects of Relaxin on Renal Myofibroblast Differentiation

Annals of the New York Academy of Sciences, 2009-04, Vol.1160 (1), p.294-299

2009

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Signal Switching after Stimulation of LGR7 Receptors by Human Relaxin 2

Annals of the New York Academy of Sciences, 2005-05, Vol.1041 (1), p.288-291

2005

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Signaling Pathways of the LGR7 and LGR8 Receptors Determined by Reporter Genes

Annals of the New York Academy of Sciences, 2005-05, Vol.1041 (1), p.292-295

2005

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Identification of Binding Sites with Differing Affinity and Potency for Relaxin Analogues on LGR7 and LGR8 Receptors

Annals of the New York Academy of Sciences, 2005-05, Vol.1041 (1), p.17-21

2005

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The β 2 ‐adrenoceptor activates a positive cAMP‐calcium feedforward loop to drive breast cancer cell invasion

The FASEB journal, 2016-03, Vol.30 (3), p.1144-1154

2016

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The pleiotropic physiological effects of relaxin are determined by the signalling pathway profile activated in target cells

The FASEB journal, 2008-03, Vol.22 (S1)

2008

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RXFP1 Couples to the Gαi3-Gβγ-PI3K-PKCζ Pathway via the Final 10 Amino Acids of the Receptor C-terminal Tail

Annals of the New York Academy of Sciences, 2009-04, Vol.1160 (1), p.117-120

2009

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Roles of the Receptor, the Ligand, and the Cell in the Signal Transduction Pathways Utilized by the Relaxin Family Peptide Receptors 1a3

Annals of the New York Academy of Sciences, 2009-04, Vol.1160 (1), p.99-104

2009

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RXFP1 Couples to the GI-i3-GbetaI3-PI3K-PKCIPG Pathway via the Final 10 Amino Acids of the Receptor C-terminal Tail

Annals of the New York Academy of Sciences, 2009-04, Vol.1160 (1), p.117-120

2009

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RXFP1 couples to the Galpha-Gbetagamma-PI3K-PKCzeta pathway via the final 10 amino acids of the receptor C-terminal tail

Annals of the New York Academy of Sciences, 2009-04, Vol.1160, p.117

2009

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First Case of 2019 Novel Coronavirus in the United States

The New England journal of medicine, 2020-03, Vol.382 (10), p.929-936

2020

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The application of targeted protein degradation technologies to G protein‐coupled receptors

Signal transduction pathways activated by insulin‐like peptide 5 at the relaxin family peptide RXFP4 receptor

Adenylyl cyclase signalling complexes - Pharmacological challenges and opportunities

Signalling in response to sub‐picomolar concentrations of active compounds: Pushing the boundaries of GPCR sensitivity

Pathological changes in GPCR signal organisation: Opportunities for targeted therapies for triple negative breast cancer

Glucagon-like peptide-1 receptor internalisation controls spatiotemporal signalling mediated by biased agonists

Neurokinin 1 receptor signaling in endosomes mediates sustained nociception and is a viable therapeutic target for prolonged pain relief

The β2‐adrenoceptor activates a positive cAMP‐calcium feedforward loop to drive breast cancer cell invasion

Constitutive formation of an RXFP1‐signalosome: a novel paradigm in GPCR function and regulation

The application of artificial intelligence to accelerate G protein‐coupled receptor drug discovery

LYCHOS is a human hybrid of a plant-like PIN transporter and a GPCR

Relaxin inhibits renal myofibroblast differentiation via RXFP1, the nitric oxide pathway, and Smad2

Relaxin Activates Multiple cAMP Signaling Pathway Profiles in Different Target Cells

Roles of the Receptor, the Ligand, and the Cell in the Signal Transduction Pathways Utilized by the Relaxin Family Peptide Receptors 1-3

Investigations into the Inhibitory Effects of Relaxin on Renal Myofibroblast Differentiation

Signal Switching after Stimulation of LGR7 Receptors by Human Relaxin 2

Signaling Pathways of the LGR7 and LGR8 Receptors Determined by Reporter Genes

Identification of Binding Sites with Differing Affinity and Potency for Relaxin Analogues on LGR7 and LGR8 Receptors

The β 2 ‐adrenoceptor activates a positive cAMP‐calcium feedforward loop to drive breast cancer cell invasion

The pleiotropic physiological effects of relaxin are determined by the signalling pathway profile activated in target cells

RXFP1 Couples to the Gαi3-Gβγ-PI3K-PKCζ Pathway via the Final 10 Amino Acids of the Receptor C-terminal Tail

Roles of the Receptor, the Ligand, and the Cell in the Signal Transduction Pathways Utilized by the Relaxin Family Peptide Receptors 1a3

RXFP1 Couples to the GI-i3-GbetaI3-PI3K-PKCIPG Pathway via the Final 10 Amino Acids of the Receptor C-terminal Tail

RXFP1 couples to the Galpha-Gbetagamma-PI3K-PKCzeta pathway via the final 10 amino acids of the receptor C-terminal tail

First Case of 2019 Novel Coronavirus in the United States

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