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Targeting a neoantigen derived from a common TP53 mutation

Science (American Association for the Advancement of Science), 2021-03, Vol.371 (6533)

2021

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Long-range regulation of p53 DNA binding by its intrinsically disordered N-terminal transactivation domain

Proceedings of the National Academy of Sciences - PNAS, 2018-11, Vol.115 (48), p.E11302-E11310

2018

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Mesoscopic protein-rich clusters host the nucleation of mutant p53 amyloid fibrils

Proceedings of the National Academy of Sciences - PNAS, 2021-03, Vol.118 (10), p.1

2021

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Mechanistic basis for impaired ferroptosis in cells expressing the African-centric S47 variant of p53

Proceedings of the National Academy of Sciences - PNAS, 2019-04, Vol.116 (17), p.8390-8396

2019

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Interaction between p53 N terminus and core domain regulates specific and nonspecific DNA binding

Proceedings of the National Academy of Sciences - PNAS, 2019-04, Vol.116 (18), p.8859-8868

2019

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Recognition of the disordered p53 transactivation domain by the transcriptional adapter zinc finger domains of CREB-binding protein

Proceedings of the National Academy of Sciences - PNAS, 2016-03, Vol.113 (13), p.E1853-E1862

2016

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A phosphorylation-dependent switch in the disordered p53 transactivation domain regulates DNA binding

Proceedings of the National Academy of Sciences - PNAS, 2021-01, Vol.118 (1), p.1

2021

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Design of a molecular support for cryo-EM structure determination

Proceedings of the National Academy of Sciences - PNAS, 2016-11, Vol.113 (47), p.E7456-E7463

2016

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Propagation of aggregated p53: Cross-reaction and coaggregation vs. seeding

Proceedings of the National Academy of Sciences - PNAS, 2015-02, Vol.112 (8), p.2443-2448

2015

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Sulfated glycosaminoglycans mediate prion-like behavior of p53 aggregates

Proceedings of the National Academy of Sciences - PNAS, 2020-12, Vol.117 (52), p.33225-33234

2020

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iASPP mediates p53 selectivity through a modular mechanism fine-tuning DNA recognition

Proceedings of the National Academy of Sciences - PNAS, 2019-08, Vol.116 (35), p.17470-17479

2019

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Structural basis for high-affinity peptide inhibition of p53 interactions with MDM2 and MDMX

Proceedings of the National Academy of Sciences - PNAS, 2009-03, Vol.106 (12), p.4665-4670

2009

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Multisite aggregation of p53 and implications for drug rescue

Proceedings of the National Academy of Sciences - PNAS, 2017-03, Vol.114 (13), p.E2634-E2643

2017

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Secondary interaction between MDMX and p53 core domain inhibits p53 DNA binding

Proceedings of the National Academy of Sciences - PNAS, 2016-05, Vol.113 (19), p.E2558-E2563

2016

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p53Ψ is a transcriptionally inactive p53 isoform able to reprogram cells toward a metastatic-like state

Proceedings of the National Academy of Sciences - PNAS, 2014-08, Vol.111 (32), p.E3287-E3296

2014

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Direct Activation of Bax by p53 Mediates Mitochondrial Membrane Permeabilization and Apoptosis

Science (American Association for the Advancement of Science), 2004-02, Vol.303 (5660), p.1010-1014

2004

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single-molecule characterization of p53 search on DNA

Proceedings of the National Academy of Sciences - PNAS, 2011-01, Vol.108 (2), p.563-568

2011

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Autoinhibition of MDMX by intramolecular p53 mimicry

Proceedings of the National Academy of Sciences - PNAS, 2015-04, Vol.112 (15), p.4624-4629

2015

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MOZ increases p53 acetylation and premature senescence through its complex formation with PML

Proceedings of the National Academy of Sciences - PNAS, 2013-03, Vol.110 (10), p.3895-3900

2013

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Cooperative regulation of p53 by modulation of ternary complex formation with CBP/p300 and HDM2

Proceedings of the National Academy of Sciences - PNAS, 2009-04, Vol.106 (16), p.6591-6596

2009

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Kinetic mechanism of p53 oncogenic mutant aggregation and its inhibition

Proceedings of the National Academy of Sciences - PNAS, 2012-08, Vol.109 (34), p.13584-13589

2012

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Structure of tumor suppressor p53 and its intrinsically disordered N-terminal transactivation domain

Proceedings of the National Academy of Sciences - PNAS, 2008-04, Vol.105 (15), p.5762-5767

2008

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Structural Evolution of p53, p63, and p73: Implication for Heterotetramer Formation

Proceedings of the National Academy of Sciences - PNAS, 2009-10, Vol.106 (42), p.17705-17710

2009

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Quaternary structures of tumor suppressor p53 and a specific p53-DNA complex

Proceedings of the National Academy of Sciences - PNAS, 2007-07, Vol.104 (30), p.12324-12329

2007

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XAF1 directs apoptotic switch of p53 signaling through activation of HIPK2 and ZNF313

Proceedings of the National Academy of Sciences - PNAS, 2014-10, Vol.111 (43), p.15532-15537

2014

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Targeting a neoantigen derived from a common TP53 mutation

Long-range regulation of p53 DNA binding by its intrinsically disordered N-terminal transactivation domain

Mesoscopic protein-rich clusters host the nucleation of mutant p53 amyloid fibrils

Mechanistic basis for impaired ferroptosis in cells expressing the African-centric S47 variant of p53

Interaction between p53 N terminus and core domain regulates specific and nonspecific DNA binding

Recognition of the disordered p53 transactivation domain by the transcriptional adapter zinc finger domains of CREB-binding protein

A phosphorylation-dependent switch in the disordered p53 transactivation domain regulates DNA binding

Design of a molecular support for cryo-EM structure determination

Propagation of aggregated p53: Cross-reaction and coaggregation vs. seeding

Sulfated glycosaminoglycans mediate prion-like behavior of p53 aggregates

iASPP mediates p53 selectivity through a modular mechanism fine-tuning DNA recognition

Structural basis for high-affinity peptide inhibition of p53 interactions with MDM2 and MDMX

Multisite aggregation of p53 and implications for drug rescue

Secondary interaction between MDMX and p53 core domain inhibits p53 DNA binding

p53Ψ is a transcriptionally inactive p53 isoform able to reprogram cells toward a metastatic-like state

Direct Activation of Bax by p53 Mediates Mitochondrial Membrane Permeabilization and Apoptosis

single-molecule characterization of p53 search on DNA

Autoinhibition of MDMX by intramolecular p53 mimicry

MOZ increases p53 acetylation and premature senescence through its complex formation with PML

Cooperative regulation of p53 by modulation of ternary complex formation with CBP/p300 and HDM2

Kinetic mechanism of p53 oncogenic mutant aggregation and its inhibition

Structure of tumor suppressor p53 and its intrinsically disordered N-terminal transactivation domain

Structural Evolution of p53, p63, and p73: Implication for Heterotetramer Formation

Quaternary structures of tumor suppressor p53 and a specific p53-DNA complex

XAF1 directs apoptotic switch of p53 signaling through activation of HIPK2 and ZNF313

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