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Removing T-cell epitopes with computational protein design

Proceedings of the National Academy of Sciences - PNAS, 2014-06, Vol.111 (23), p.8577-8582

2014

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Recombinant immunotoxin engineered for low immunogenicity and antigenicity by identifying and silencing human B-cell epitopes

Proceedings of the National Academy of Sciences - PNAS, 2012-07, Vol.109 (29), p.11782-11787

2012

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Control of large, established tumor xenografts with genetically retargeted human T cells containing CD28 and CD137 domains

Proceedings of the National Academy of Sciences - PNAS, 2009-03, Vol.106 (9), p.3360-3365

2009

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Recombinant immunotoxin for cancer treatment with low immunogenicity by identification and silencing of human T-cell epitopes

Proceedings of the National Academy of Sciences - PNAS, 2014-06, Vol.111 (23), p.8571-8576

2014

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Isolation of Anti-CD22 Fv with High Affinity by Fv Display on Human Cells

Proceedings of the National Academy of Sciences - PNAS, 2006-06, Vol.103 (25), p.9637-9642

2006

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Anti-BCMA immunotoxins produce durable complete remissions in two mouse myeloma models

Proceedings of the National Academy of Sciences - PNAS, 2019-03, Vol.116 (10), p.4592-4598

2019

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Systemic administration of a bispecific antibody targeting EGFRvIII successfully treats intracerebral glioma

Proceedings of the National Academy of Sciences - PNAS, 2013-01, Vol.110 (1), p.270-275

2013

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Immunotherapy-based targeting of MSLN⁺ activated portal fibroblasts is a strategy for treatment of cholestatic liver fibrosis

Proceedings of the National Academy of Sciences - PNAS, 2021-07, Vol.118 (29), p.1-12

2021

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Immunotoxin SS1P is rapidly removed by proximal tubule cells of kidney, whose damage contributes to albumin loss in urine

Proceedings of the National Academy of Sciences - PNAS, 2020-03, Vol.117 (11), p.6086-6091

2020

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Recombinant immunotoxin against B-cell malignancies with no immunogenicity in mice by removal of B-cell epitopes

Proceedings of the National Academy of Sciences - PNAS, 2011-04, Vol.108 (14), p.5742-5747

2011

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immunotoxin with greatly reduced immunogenicity by identification and removal of B cell epitopes

Proceedings of the National Academy of Sciences - PNAS, 2008-08, Vol.105 (32), p.11311-11316

2008

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Identification and elimination of an immunodominant T-cell epitope in recombinant immunotoxins based on Pseudomonas exotoxin A

Proceedings of the National Academy of Sciences - PNAS, 2012-12, Vol.109 (51), p.E3597-E3603

2012

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Immunotoxin and Taxol synergy results from a decrease in shed mesothelin levels in the extracellular space of tumors

Proceedings of the National Academy of Sciences - PNAS, 2007-10, Vol.104 (43), p.17099-17104

2007

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Loss of diphthamide pre-activates NF-κB and death receptor pathways and renders MCF7 cells hypersensitive to tumor necrosis factor

Proceedings of the National Academy of Sciences - PNAS, 2015-08, Vol.112 (34), p.10732-10737

2015

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Whole-genome RNAi screen highlights components of the endoplasmic reticulum/Golgi as a source of resistance to immunotoxin-mediated cytotoxicity

Proceedings of the National Academy of Sciences - PNAS, 2015-03, Vol.112 (10), p.E1135-E1142

2015

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Depletion of regulatory T cells in tumors with an anti-CD25 immunotoxin induces CD8 T cell-mediated systemic antitumor immunity

Proceedings of the National Academy of Sciences - PNAS, 2019-03, Vol.116 (10), p.4575-4582

2019

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Immunotoxin resistance via reversible methylation of the DPH4 promoter is a unique survival strategy

Proceedings of the National Academy of Sciences - PNAS, 2012-05, Vol.109 (18), p.6898-6903

2012

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Acetylcholine Enhancement in the Nucleus Accumbens Prevents Addictive Behaviors of Cocaine and Morphine

Proceedings of the National Academy of Sciences - PNAS, 2003-05, Vol.100 (10), p.6169-6173

2003

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Identification of Proangiogenic Genes and Pathways by High-Throughput Functional Genomics: TBK1 and the IRF3 Pathway

Proceedings of the National Academy of Sciences - PNAS, 2006-03, Vol.103 (11), p.4240-4245

2006

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Site-Specific Chemical Modification with Polyethylene Glycol of Recombinant Immunotoxin Anti-Tac(Fv)-PE38 (LMB-2) Improves Antitumor Activity and Reduces Animal Toxicity and Immunogenicity

Proceedings of the National Academy of Sciences - PNAS, 2000-07, Vol.97 (15), p.8548-8553

2000

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Impairment of Reward-Related Learning by Cholinergic Cell Ablation in the Striatum

Proceedings of the National Academy of Sciences - PNAS, 2003-06, Vol.100 (13), p.7965-7970

2003

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Evidence for Two Nonidentical Drug-Interaction Sites in the Human P-Glycoprotein

Proceedings of the National Academy of Sciences - PNAS, 1997-09, Vol.94 (20), p.10594-10599

1997

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model for obesity and gigantism due to disruption of the Ankrd26 gene

Proceedings of the National Academy of Sciences - PNAS, 2008-01, Vol.105 (1), p.270-275

2008

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Synaptic Integration Mediated by Striatal Cholinergic Interneurons in Basal Ganglia Function

Science (American Association for the Advancement of Science), 2000-07, Vol.289 (5479), p.633-637

2000

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Finding Fusion Genes Resulting from Chromosome Rearrangement by Analyzing the Expressed Sequence Databases

Proceedings of the National Academy of Sciences - PNAS, 2004-09, Vol.101 (36), p.13257-13261

2004

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Removing T-cell epitopes with computational protein design

Recombinant immunotoxin engineered for low immunogenicity and antigenicity by identifying and silencing human B-cell epitopes

Control of large, established tumor xenografts with genetically retargeted human T cells containing CD28 and CD137 domains

Recombinant immunotoxin for cancer treatment with low immunogenicity by identification and silencing of human T-cell epitopes

Isolation of Anti-CD22 Fv with High Affinity by Fv Display on Human Cells

Anti-BCMA immunotoxins produce durable complete remissions in two mouse myeloma models

Systemic administration of a bispecific antibody targeting EGFRvIII successfully treats intracerebral glioma

Immunotherapy-based targeting of MSLN⁺ activated portal fibroblasts is a strategy for treatment of cholestatic liver fibrosis

Immunotoxin SS1P is rapidly removed by proximal tubule cells of kidney, whose damage contributes to albumin loss in urine

Recombinant immunotoxin against B-cell malignancies with no immunogenicity in mice by removal of B-cell epitopes

immunotoxin with greatly reduced immunogenicity by identification and removal of B cell epitopes

Identification and elimination of an immunodominant T-cell epitope in recombinant immunotoxins based on Pseudomonas exotoxin A

Immunotoxin and Taxol synergy results from a decrease in shed mesothelin levels in the extracellular space of tumors

Loss of diphthamide pre-activates NF-κB and death receptor pathways and renders MCF7 cells hypersensitive to tumor necrosis factor

Whole-genome RNAi screen highlights components of the endoplasmic reticulum/Golgi as a source of resistance to immunotoxin-mediated cytotoxicity

Depletion of regulatory T cells in tumors with an anti-CD25 immunotoxin induces CD8 T cell-mediated systemic antitumor immunity

Immunotoxin resistance via reversible methylation of the DPH4 promoter is a unique survival strategy

Acetylcholine Enhancement in the Nucleus Accumbens Prevents Addictive Behaviors of Cocaine and Morphine

Identification of Proangiogenic Genes and Pathways by High-Throughput Functional Genomics: TBK1 and the IRF3 Pathway

Site-Specific Chemical Modification with Polyethylene Glycol of Recombinant Immunotoxin Anti-Tac(Fv)-PE38 (LMB-2) Improves Antitumor Activity and Reduces Animal Toxicity and Immunogenicity

Impairment of Reward-Related Learning by Cholinergic Cell Ablation in the Striatum

Evidence for Two Nonidentical Drug-Interaction Sites in the Human P-Glycoprotein

model for obesity and gigantism due to disruption of the Ankrd26 gene

Synaptic Integration Mediated by Striatal Cholinergic Interneurons in Basal Ganglia Function

Finding Fusion Genes Resulting from Chromosome Rearrangement by Analyzing the Expressed Sequence Databases

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