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Design, synthesis and mechanistic study of new 1,2,4-triazole derivatives as antimicrobial agents

Bioorganic chemistry, 2021-06, Vol.111, p.104841-104841, Article 104841

2021

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Design, synthesis, biological assessment, and in-Silico studies of 1,2,4-triazolo[1,5-a]pyrimidine derivatives as tubulin polymerization inhibitors

Bioorganic chemistry, 2022-04, Vol.121, p.105687-105687, Article 105687

2022

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Determination of Bendamustine, Gemcitabine and Vinorelbine (BEGEV) regimen in spiked human plasma using multivariate model update chemometric methods

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 2023-10, Vol.299, p.122836, Article 122836

2023

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Design, synthesis, molecular docking and antiproliferative activity of some novel benzothiazole derivatives targeting EGFR/HER2 and TS

Bioorganic chemistry, 2020-08, Vol.101, p.103976-103976, Article 103976

2020

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Discovery of novel urea-diarylpyrazole hybrids as dual COX-2/sEH inhibitors with improved anti-inflammatory activity and highly reduced cardiovascular risks

European journal of medicinal chemistry, 2020-11, Vol.205, p.112662, Article 112662

2020

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Design, synthesis and mechanistic studies of novel imidazo[1,2-a]pyridines as anticancer agents

Bioorganic chemistry, 2022-11, Vol.128, p.106042-106042, Article 106042

2022

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Design, synthesis and anticancer evaluation of novel spirobenzo[h]chromene and spirochromane derivatives with dual EGFR and B-RAF inhibitory activities

European journal of medicinal chemistry, 2018-04, Vol.150, p.567-578

2018

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Synthesis of 4-(thiazol-2-ylamino)-benzenesulfonamides with carbonic anhydrase I, II and IX inhibitory activity and cytotoxic effects against breast cancer cell lines

Bioorganic & medicinal chemistry, 2016-07, Vol.24 (13), p.3043-3051

2016

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Design, synthesis and molecular modeling studies of 2-styrylquinazoline derivatives as EGFR inhibitors and apoptosis inducers

Bioorganic chemistry, 2020-12, Vol.105, p.104358, Article 104358

2020

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Five spectrophotometric methods for simultaneous determination of Amlodipine besylate and celecoxib in presence of its toxic impurity

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 2021-12, Vol.263, p.120137, Article 120137

2021

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Development of certain aminoquinazoline scaffolds as potential multitarget anticancer agents with apoptotic and anti-proliferative effects: Design, synthesis and biological evaluation

Bioorganic chemistry, 2023-06, Vol.135, p.106496-106496, Article 106496

2023

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HCV NS5B RdRp mutations and their effects on ligand binding affinity

International journal of modelling & simulation, 2022-05, Vol.42 (3), p.415-425

2022

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Design, synthesis and mechanistic study of novel diarylpyrazole derivatives as anti-inflammatory agents with reduced cardiovascular side effects

Bioorganic chemistry, 2021-11, Vol.116, p.105394, Article 105394

2021

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Design, synthesis and mechanistic studies of benzophenones hydrazone derivatives as cathepsin inhibitors

Journal of molecular structure, 2023-02, Vol.1274, p.134583, Article 134583

2023

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Design, synthesis and biological evaluation of new imidazo[1,2-a]pyridine derivatives as selective COX-2 inhibitors

Journal of molecular structure, 2022-02, Vol.1250, p.131652, Article 131652

2022

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Design, synthesis and anti-inflammatory/analgesic evaluation of novel di-substituted urea derivatives bearing diaryl-1,2,4-triazole with dual COX-2/sEH inhibitory activities

Journal of molecular structure, 2021-09, Vol.1240, p.130565, Article 130565

2021

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Therapeutic drug monitoring of two co-administered drugs through development of two ecological chromatographic methods: Invivo application

Microchemical journal, 2020-07, Vol.156, p.104935, Article 104935

2020

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Albendazole-loaded cubosomes interrupt the ERK1/2-HIF-1α-p300/CREB axis in mice intoxicated with diethylnitrosamine: A new paradigm in drug repurposing for the inhibition of hepatocellular carcinoma progression

Biomedicine & pharmacotherapy, 2021-10, Vol.142, p.112029, Article 112029

2021

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Neuroprotective Effect of Gold Nanoparticles and Alpha-Lipoic Acid Mixture against Radiation-Induced Brain Damage in Rats

International journal of molecular sciences, 2022-09, Vol.23 (17), p.9640

2022

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Interference With the AMPKα/mTOR/NLRP3 Signaling and the IL-23/IL-17 Axis Effectively Protects Against the Dextran Sulfate Sodium Intoxication in Rats: A New Paradigm in Empagliflozin and Metformin Reprofiling for the Management of Ulcerative Colitis

Frontiers in pharmacology, 2021-08, Vol.12, p.719984-719984

2021

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BBG enhances OLT1177-induced NLRP3 inflammasome inactivation by targeting P2X7R/NLRP3 and MyD88/NF-κB signaling in DSS-induced colitis in rats

Life sciences (1973), 2021-04, Vol.270, p.119123, Article 119123

2021

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Coomassie brilliant blue G-250 dye attenuates bleomycin-induced lung fibrosis by regulating the NF-κB and NLRP3 crosstalk: A novel approach for filling an unmet medical need

Biomedicine & pharmacotherapy, 2022-04, Vol.148, p.112723-112723, Article 112723

2022

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The dynamic interplay between AMPK/NFκB signaling and NLRP3 is a new therapeutic target in inflammation: Emerging role of dapagliflozin in overcoming lipopolysaccharide-mediated lung injury

Biomedicine & pharmacotherapy, 2022-03, Vol.147, p.112628-112628, Article 112628

2022

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Hemofiltration as an Alternative for IL-6 Inhibitors in COVID-19 Cytokines Storm Associated with Underlaying Bacterial Infections: A Review Article

Infectious disorders drug targets, 2023, Vol.23 (6)

2023

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Draft genome sequence of a prodigiosin-hyperproducing Serratia marcescens strain isolated from Cairo, Egypt

G3 : genes - genomes - genetics, 2021-10, Vol.11 (10)

2021

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Design, synthesis and mechanistic study of new 1,2,4-triazole derivatives as antimicrobial agents

Design, synthesis, biological assessment, and in-Silico studies of 1,2,4-triazolo[1,5-a]pyrimidine derivatives as tubulin polymerization inhibitors

Determination of Bendamustine, Gemcitabine and Vinorelbine (BEGEV) regimen in spiked human plasma using multivariate model update chemometric methods

Design, synthesis, molecular docking and antiproliferative activity of some novel benzothiazole derivatives targeting EGFR/HER2 and TS

Discovery of novel urea-diarylpyrazole hybrids as dual COX-2/sEH inhibitors with improved anti-inflammatory activity and highly reduced cardiovascular risks

Design, synthesis and mechanistic studies of novel imidazo[1,2-a]pyridines as anticancer agents

Design, synthesis and anticancer evaluation of novel spirobenzo[h]chromene and spirochromane derivatives with dual EGFR and B-RAF inhibitory activities

Synthesis of 4-(thiazol-2-ylamino)-benzenesulfonamides with carbonic anhydrase I, II and IX inhibitory activity and cytotoxic effects against breast cancer cell lines

Design, synthesis and molecular modeling studies of 2-styrylquinazoline derivatives as EGFR inhibitors and apoptosis inducers

Five spectrophotometric methods for simultaneous determination of Amlodipine besylate and celecoxib in presence of its toxic impurity

Development of certain aminoquinazoline scaffolds as potential multitarget anticancer agents with apoptotic and anti-proliferative effects: Design, synthesis and biological evaluation

HCV NS5B RdRp mutations and their effects on ligand binding affinity

Design, synthesis and mechanistic study of novel diarylpyrazole derivatives as anti-inflammatory agents with reduced cardiovascular side effects

Design, synthesis and mechanistic studies of benzophenones hydrazone derivatives as cathepsin inhibitors

Design, synthesis and biological evaluation of new imidazo[1,2-a]pyridine derivatives as selective COX-2 inhibitors

Design, synthesis and anti-inflammatory/analgesic evaluation of novel di-substituted urea derivatives bearing diaryl-1,2,4-triazole with dual COX-2/sEH inhibitory activities

Therapeutic drug monitoring of two co-administered drugs through development of two ecological chromatographic methods: Invivo application

Albendazole-loaded cubosomes interrupt the ERK1/2-HIF-1α-p300/CREB axis in mice intoxicated with diethylnitrosamine: A new paradigm in drug repurposing for the inhibition of hepatocellular carcinoma progression

Neuroprotective Effect of Gold Nanoparticles and Alpha-Lipoic Acid Mixture against Radiation-Induced Brain Damage in Rats

Interference With the AMPKα/mTOR/NLRP3 Signaling and the IL-23/IL-17 Axis Effectively Protects Against the Dextran Sulfate Sodium Intoxication in Rats: A New Paradigm in Empagliflozin and Metformin Reprofiling for the Management of Ulcerative Colitis

BBG enhances OLT1177-induced NLRP3 inflammasome inactivation by targeting P2X7R/NLRP3 and MyD88/NF-κB signaling in DSS-induced colitis in rats

Coomassie brilliant blue G-250 dye attenuates bleomycin-induced lung fibrosis by regulating the NF-κB and NLRP3 crosstalk: A novel approach for filling an unmet medical need

The dynamic interplay between AMPK/NFκB signaling and NLRP3 is a new therapeutic target in inflammation: Emerging role of dapagliflozin in overcoming lipopolysaccharide-mediated lung injury

Hemofiltration as an Alternative for IL-6 Inhibitors in COVID-19 Cytokines Storm Associated with Underlaying Bacterial Infections: A Review Article

Draft genome sequence of a prodigiosin-hyperproducing Serratia marcescens strain isolated from Cairo, Egypt

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