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Antifolates in cancer therapy: Structure, activity and mechanisms of drug resistance

Drug resistance updates, 2012-08, Vol.15 (4), p.183-210

2012

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Towards the overcoming of anticancer drug resistance mediated by p53 mutations

Drug resistance updates, 2020-03, Vol.49, p.100671-100671, Article 100671

2020

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Microenvironment acidity as a major determinant of tumor chemoresistance: Proton pump inhibitors (PPIs) as a novel therapeutic approach

Drug resistance updates, 2015-11, Vol.23, p.69-78

2015

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Structure and function of ABCG2-rich extracellular vesicles mediating multidrug resistance

PloS one, 2011-01, Vol.6 (1), p.e16007-e16007

2011

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MicroRNAs as a drug resistance mechanism to targeted therapies in EGFR-mutated NSCLC: Current implications and future directions

Drug resistance updates, 2019-01, Vol.42, p.1-11

2019

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Targeted Nanoparticles Harboring Jasmine-Oil-Entrapped Paclitaxel for Elimination of Lung Cancer Cells

International journal of molecular sciences, 2021-01, Vol.22 (3), p.1019

2021

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Deciphering molecular mechanisms underlying chemoresistance in relapsed AML patients: towards precision medicine overcoming drug resistance

Cancer cell international, 2021-01, Vol.21 (1), p.53-53, Article 53

2021

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Beta-casein Nanoparticles as an Oral Delivery System for Chemotherapeutic Drugs: Impact of Drug Structure and Properties on Co-assembly

Pharmaceutical research, 2010-10, Vol.27 (10), p.2175-2186

2010

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Overcoming multidrug resistance via photodestruction of ABCG2-rich extracellular vesicles sequestering photosensitive chemotherapeutics

PloS one, 2012-04, Vol.7 (4), p.e35487-e35487

2012

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Selective Targeting and Eradication of Various Human Non-Small Cell Lung Cancer Cell Lines Using Self-Assembled Aptamer-Decorated Nanoparticles

Pharmaceutics, 2022-08, Vol.14 (8), p.1650

2022

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Molecular basis and rationale for combining immune checkpoint inhibitors with chemotherapy in non-small cell lung cancer

Drug resistance updates, 2019-09, Vol.46, p.100644-100644, Article 100644

2019

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Endothelial Progenitor Cells Promote Osteosarcoma Progression and Invasiveness via AKT/PI3K Signaling

Cancers, 2023-03, Vol.15 (6), p.1818

2023

Volltextzugriff (PDF)

Folylpoly-γ-glutamate synthetase: A key determinant of folate homeostasis and antifolate resistance in cancer

Drug resistance updates, 2016-09, Vol.28, p.43-64

2016

Volltextzugriff (PDF)

Long non-coding RNAs as a determinant of cancer drug resistance: Towards the overcoming of chemoresistance via modulation of lncRNAs

Drug resistance updates, 2020-05, Vol.50, p.100683, Article 100683

2020

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Targeted nanomedicine modalities for prostate cancer treatment

Drug resistance updates, 2021-05, Vol.56, p.100762-100762, Article 100762

2021

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The role of multidrug resistance efflux transporters in antifolate resistance and folate homeostasis

Drug resistance updates, 2006-08, Vol.9 (4), p.227-246

Assaraf, Yehuda G.

2006

Volltextzugriff (PDF)

Medicinal chemistry strategies to discover P-glycoprotein inhibitors: An update

Drug resistance updates, 2020-03, Vol.49, p.100681-100681, Article 100681

2020

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The EGFR pathway regulates BCRP expression in NSCLC cells: role of erlotinib

Current drug targets, 2014-01, Vol.15 (14), p.1322

2014

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Harnessing Gene Expression Profiles for the Identification of Ex Vivo Drug Response Genes in Pediatric Acute Myeloid Leukemia

Cancers, 2020-05, Vol.12 (5), p.1247

2020

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Role of drug catabolism, modulation of oncogenic signaling and tumor microenvironment in microbe-mediated pancreatic cancer chemoresistance

Drug resistance updates, 2022-09, Vol.64, p.100864, Article 100864

2022

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PCFT/SLC46A1 promoter methylation and restoration of gene expression in human leukemia cells

Biochemical and biophysical research communications, 2008-11, Vol.376 (4), p.787-792

2008

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β-Casein nanoparticle-based oral drug delivery system for potential treatment of gastric carcinoma: Stability, target-activated release and cytotoxicity

European journal of pharmaceutics and biopharmaceutics, 2012-02, Vol.80 (2), p.298-305

2012

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Inhibition of the PI3K-Akt signaling pathway disrupts ABCG2-rich extracellular vesicles and overcomes multidrug resistance in breast cancer cells

Biochemical pharmacology, 2012-05, Vol.83 (10), p.1340-1348

2012

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Surmounting cancer drug resistance: New insights from the perspective of N6-methyladenosine RNA modification

Drug resistance updates, 2020-12, Vol.53, p.100720-100720, Article 100720

2020

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Methotrexate resistance in relation to treatment outcome in childhood acute lymphoblastic leukemia

Journal of hematology and oncology, 2015-05, Vol.8 (1), p.61-61, Article 61

2015

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Antifolates in cancer therapy: Structure, activity and mechanisms of drug resistance

Towards the overcoming of anticancer drug resistance mediated by p53 mutations

Microenvironment acidity as a major determinant of tumor chemoresistance: Proton pump inhibitors (PPIs) as a novel therapeutic approach

Structure and function of ABCG2-rich extracellular vesicles mediating multidrug resistance

MicroRNAs as a drug resistance mechanism to targeted therapies in EGFR-mutated NSCLC: Current implications and future directions

Targeted Nanoparticles Harboring Jasmine-Oil-Entrapped Paclitaxel for Elimination of Lung Cancer Cells

Deciphering molecular mechanisms underlying chemoresistance in relapsed AML patients: towards precision medicine overcoming drug resistance

Beta-casein Nanoparticles as an Oral Delivery System for Chemotherapeutic Drugs: Impact of Drug Structure and Properties on Co-assembly

Overcoming multidrug resistance via photodestruction of ABCG2-rich extracellular vesicles sequestering photosensitive chemotherapeutics

Selective Targeting and Eradication of Various Human Non-Small Cell Lung Cancer Cell Lines Using Self-Assembled Aptamer-Decorated Nanoparticles

Molecular basis and rationale for combining immune checkpoint inhibitors with chemotherapy in non-small cell lung cancer

Endothelial Progenitor Cells Promote Osteosarcoma Progression and Invasiveness via AKT/PI3K Signaling

Folylpoly-γ-glutamate synthetase: A key determinant of folate homeostasis and antifolate resistance in cancer

Long non-coding RNAs as a determinant of cancer drug resistance: Towards the overcoming of chemoresistance via modulation of lncRNAs

Targeted nanomedicine modalities for prostate cancer treatment

The role of multidrug resistance efflux transporters in antifolate resistance and folate homeostasis

Medicinal chemistry strategies to discover P-glycoprotein inhibitors: An update

The EGFR pathway regulates BCRP expression in NSCLC cells: role of erlotinib

Harnessing Gene Expression Profiles for the Identification of Ex Vivo Drug Response Genes in Pediatric Acute Myeloid Leukemia

Role of drug catabolism, modulation of oncogenic signaling and tumor microenvironment in microbe-mediated pancreatic cancer chemoresistance

PCFT/SLC46A1 promoter methylation and restoration of gene expression in human leukemia cells

β-Casein nanoparticle-based oral drug delivery system for potential treatment of gastric carcinoma: Stability, target-activated release and cytotoxicity

Inhibition of the PI3K-Akt signaling pathway disrupts ABCG2-rich extracellular vesicles and overcomes multidrug resistance in breast cancer cells

Surmounting cancer drug resistance: New insights from the perspective of N6-methyladenosine RNA modification

Methotrexate resistance in relation to treatment outcome in childhood acute lymphoblastic leukemia

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