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Targeting HSP70: The second potentially druggable heat shock protein and molecular chaperone?

Cell cycle (Georgetown, Tex.), 2010-04, Vol.9 (8), p.1542-1550

2010

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Benzimidazole inhibitors of the protein kinase CHK2: Clarification of the binding mode by flexible side chain docking and protein–ligand crystallography

Bioorganic & medicinal chemistry, 2012-11, Vol.20 (22), p.6630-6639

2012

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Structure-based design of molecular cancer therapeutics

Trends in biotechnology (Regular ed.), 2009-05, Vol.27 (5), p.315-328

2009

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C8-substituted pyrido[3,4-d]pyrimidin-4(3H)-ones: Studies towards the identification of potent, cell penetrant Jumonji C domain containing histone lysine demethylase 4 subfamily (KDM4) inhibitors, compound profiling in cell-based target engagement assays

European journal of medicinal chemistry, 2019-09, Vol.177, p.316-337

2019

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Identification of autophosphorylation inhibitors of the inositol-requiring enzyme 1 alpha (IRE1α) by high-throughput screening using a DELFIA assay

Journal of biomolecular screening, 2013-03, Vol.18 (3), p.298-308

2013

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Oxidation state of the active-site cysteine in protein tyrosine phosphatase 1B

Nature (London), 2003-06, Vol.423 (6941), p.773-777

2003

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Synthesis and profiling of a 3-aminopyridin-2-one-based kinase targeted fragment library: Identification of 3-amino-5-(pyridin-4-yl)pyridin-2(1H)-one scaffold for monopolar spindle 1 (MPS1) and Aurora kinases inhibition

Bioorganic & medicinal chemistry, 2018-07, Vol.26 (11), p.3021-3029

2018

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A fragment-based approach applied to a highly flexible target: Insights and challenges towards the inhibition of HSP70 isoforms

Scientific reports, 2016-10, Vol.6 (1), p.34701-34701, Article 34701

2016

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Fragment-based screening maps inhibitor interactions in the ATP-binding site of checkpoint kinase 2

PloS one, 2013-06, Vol.8 (6), p.e65689-e65689

2013

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Unveiling the Secrets of the Ancestral PI3 Kinase Vps34

Cancer cell, 2010-05, Vol.17 (5), p.421-423

2010

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Insights into the Conformational Variability and Regulation of Human Nek2 Kinase

Journal of molecular biology, 2009-02, Vol.386 (2), p.476-485

2009

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PI(3) kinases: revealing the delta lady

Nature chemical biology, 2010-02, Vol.6 (2), p.82

2010

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Crystal structure of truncated human βB1‐crystallin

Protein science, 2003-11, Vol.12 (11), p.2606-2612

2003

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Fragment-based methods in drug discovery: it's the small things that matter

Current topics in medicinal chemistry, 2009, Vol.9 (18), p.1676

2009

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Crystallization of Enzyme IIB of the Cellobiose-specific Phosphotransferase System of Escherichia coli

Journal of molecular biology, 1994-06, Vol.239 (4), p.588-590

1994

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Targeting HSP70: The second potentially druggable heat shock protein and molecular chaperone?

Benzimidazole inhibitors of the protein kinase CHK2: Clarification of the binding mode by flexible side chain docking and protein–ligand crystallography

Structure-based design of molecular cancer therapeutics

C8-substituted pyrido[3,4-d]pyrimidin-4(3H)-ones: Studies towards the identification of potent, cell penetrant Jumonji C domain containing histone lysine demethylase 4 subfamily (KDM4) inhibitors, compound profiling in cell-based target engagement assays

Identification of autophosphorylation inhibitors of the inositol-requiring enzyme 1 alpha (IRE1α) by high-throughput screening using a DELFIA assay

Oxidation state of the active-site cysteine in protein tyrosine phosphatase 1B

Synthesis and profiling of a 3-aminopyridin-2-one-based kinase targeted fragment library: Identification of 3-amino-5-(pyridin-4-yl)pyridin-2(1H)-one scaffold for monopolar spindle 1 (MPS1) and Aurora kinases inhibition

Discovering cell-active BCL6 inhibitors: effectively combining biochemical HTS with multiple biophysical techniques, X-ray crystallography and cell-based assays

A fragment-based approach applied to a highly flexible target: Insights and challenges towards the inhibition of HSP70 isoforms

Fragment-based screening maps inhibitor interactions in the ATP-binding site of checkpoint kinase 2

Unveiling the Secrets of the Ancestral PI3 Kinase Vps34

Insights into the Conformational Variability and Regulation of Human Nek2 Kinase

PI(3) kinases: revealing the delta lady

Crystal structure of truncated human βB1‐crystallin

Fragment-based methods in drug discovery: it's the small things that matter

Crystallization of Enzyme IIB of the Cellobiose-specific Phosphotransferase System of Escherichia coli

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