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Explanation of an unusual substituent effect in the benzylation of anisole and identification of the origin of the active sites in Clayzic

Tetrahedron letters, 1993-05, Vol.34 (20), p.3339-3342

1993

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Synthesis of Chiral Amines by C–C Bond Formation with Photoredox Catalysis

Synthesis (Stuttgart), 2021-07, Vol.53 (14), p.2319-2341

2021

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Polyunsaturated fatty acid amides from the Zanthoxylum genus - from culinary curiosities to probes for chemical biology

Natural product reports, 2018-01, Vol.35 (1), p.54-74

2018

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Inulin for surimi gel fortification: Performance and molecular weight-dependent effects

Carbohydrate polymers, 2023-04, Vol.305, p.120550-120550, Article 120550

2023

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Discovery of structural diverse reversible BTK inhibitors utilized to develop a novel in vivo CD69 and CD86 PK/PD mouse model

Bioorganic & medicinal chemistry letters, 2023-01, Vol.80, p.129108, Article 129108

2023

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Studies of intramolecular Diels–Alder reactions of nitroalkenes for the stereocontrolled synthesis of trans-decalin ring systems

Tetrahedron letters, 2011-04, Vol.52 (17), p.2120-2123

2011

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Substituted benzyloxytricyclic compounds as retinoic acid-related orphan receptor gamma t (RORγt) agonists

Bioorganic & medicinal chemistry letters, 2020-06, Vol.30 (12), p.127204-127204, Article 127204

2020

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Discovery and SAR of aryl hydroxy pyrimidinones as potent small molecule agonists of the GPCR APJ

Bioorganic & medicinal chemistry letters, 2020-04, Vol.30 (7), p.126955-126955, Article 126955

2020

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Substituted diaryl ether compounds as retinoic acid-related orphan Receptor-γt (RORγt) agonists

Bioorganic & medicinal chemistry letters, 2021-03, Vol.35, p.127778-127778, Article 127778

2021

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Synthesis and anti-HIV activity of new alkenyldiarylmethane (ADAM) non-nucleoside reverse transcriptase inhibitors (NNRTIs) incorporating benzoxazolone and benzisoxazole rings

Bioorganic & medicinal chemistry, 2006-04, Vol.14 (7), p.2366-2374

2006

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A cell-based approach to characterize antimicrobial compounds through kinetic dose response

Bioorganic & medicinal chemistry, 2016-12, Vol.24 (24), p.6315-6319

2016

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Heterologous expression and biochemical characterisation of cyanotoxin biosynthesis pathways

Natural product reports, 2019-08, Vol.36 (8), p.1117-1136

2019

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Use of polystyrene-supported 2-isobutoxy-1-isobutoxycarbonyl-1,2-dihydroquinoline for the preparation of a hapten–protein conjugate for antibody development

Bioorganic & medicinal chemistry letters, 2010-03, Vol.20 (5), p.1792-1795

2010

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Semi-synthetic analogues of thiostrepton delimit the critical nature of tail region modifications in the control of protein biosynthesis and antibacterial activity

Bioorganic & medicinal chemistry, 2010-06, Vol.18 (12), p.4231-4237

2010

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Discovery of novel pyridinones as MGAT2 inhibitors for the treatment of metabolic disorders

Bioorganic & medicinal chemistry letters, 2023-07, Vol.91, p.129362-129362, Article 129362

2023

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Optimization of novel reversible Bruton’s tyrosine kinase inhibitors identified using Tethering-fragment-based screens

Bioorganic & medicinal chemistry, 2019-07, Vol.27 (13), p.2905-2913

2019

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Utilizing structure based drug design and metabolic soft spot identification to optimize the in vitro potency and in vivo pharmacokinetic properties leading to the discovery of novel reversible Bruton’s tyrosine kinase inhibitors

Bioorganic & medicinal chemistry, 2021-08, Vol.44, p.116275-116275, Article 116275

2021

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Synthesis and SAR of potent and selective tetrahydropyrazinoisoquinolinone 5-HT2C receptor agonists

Bioorganic & medicinal chemistry letters, 2013-07, Vol.23 (13), p.3914-3919

2013

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Non-basic azolotriazinone MCHR1 antagonists for the treatment of obesity: An empirical brain-exposures-driven candidate selection for in vivo efficacy studies

Bioorganic & medicinal chemistry letters, 2015-10, Vol.25 (20), p.4412-4418

2015

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Dihydropyrrolopyrazol-6-one MCHR1 antagonists for the treatment of obesity: Insights on in vivo efficacy from a novel FLIPR assay setup

Bioorganic & medicinal chemistry letters, 2015-07, Vol.25 (14), p.2793-2799

2015

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Synthesis and SAR of 2,3,3a,4-tetrahydro-1H-pyrrolo[3,4-c]isoquinolin-5(9bH)-ones as 5-HT2C receptor agonists

Bioorganic & medicinal chemistry letters, 2013-01, Vol.23 (1), p.330-335

2013

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A new and efficient synthetic route for the anxiolytic agent CL285032

Bioorganic & medicinal chemistry letters, 2011-01, Vol.21 (1), p.259-261

2011

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The discovery of BMS-457, a potent and selective CCR1 antagonist

Bioorganic & medicinal chemistry letters, 2013-07, Vol.23 (13), p.3833-3840

2013

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Synthesis and structure–activity relationships of novel indazolyl glucocorticoid receptor partial agonists

Bioorganic & medicinal chemistry letters, 2013-10, Vol.23 (19), p.5448-5451

2013

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Investigation of the alkenyldiarylmethane non-nucleoside reverse transcriptase inhibitors as potential cAMP phosphodiesterase-4B2 inhibitors

Bioorganic & medicinal chemistry, 2008-02, Vol.18 (4), p.1530-1533

2008

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Explanation of an unusual substituent effect in the benzylation of anisole and identification of the origin of the active sites in Clayzic

Synthesis of Chiral Amines by C–C Bond Formation with Photoredox Catalysis

Polyunsaturated fatty acid amides from the Zanthoxylum genus - from culinary curiosities to probes for chemical biology

Inulin for surimi gel fortification: Performance and molecular weight-dependent effects

Discovery of structural diverse reversible BTK inhibitors utilized to develop a novel in vivo CD69 and CD86 PK/PD mouse model

Studies of intramolecular Diels–Alder reactions of nitroalkenes for the stereocontrolled synthesis of trans-decalin ring systems

Substituted benzyloxytricyclic compounds as retinoic acid-related orphan receptor gamma t (RORγt) agonists

Discovery and SAR of aryl hydroxy pyrimidinones as potent small molecule agonists of the GPCR APJ

Substituted diaryl ether compounds as retinoic acid-related orphan Receptor-γt (RORγt) agonists

Synthesis and anti-HIV activity of new alkenyldiarylmethane (ADAM) non-nucleoside reverse transcriptase inhibitors (NNRTIs) incorporating benzoxazolone and benzisoxazole rings

A cell-based approach to characterize antimicrobial compounds through kinetic dose response

Heterologous expression and biochemical characterisation of cyanotoxin biosynthesis pathways

Use of polystyrene-supported 2-isobutoxy-1-isobutoxycarbonyl-1,2-dihydroquinoline for the preparation of a hapten–protein conjugate for antibody development

Semi-synthetic analogues of thiostrepton delimit the critical nature of tail region modifications in the control of protein biosynthesis and antibacterial activity

Discovery of novel pyridinones as MGAT2 inhibitors for the treatment of metabolic disorders

Optimization of novel reversible Bruton’s tyrosine kinase inhibitors identified using Tethering-fragment-based screens

Utilizing structure based drug design and metabolic soft spot identification to optimize the in vitro potency and in vivo pharmacokinetic properties leading to the discovery of novel reversible Bruton’s tyrosine kinase inhibitors

Synthesis and SAR of potent and selective tetrahydropyrazinoisoquinolinone 5-HT2C receptor agonists

Non-basic azolotriazinone MCHR1 antagonists for the treatment of obesity: An empirical brain-exposures-driven candidate selection for in vivo efficacy studies

Dihydropyrrolopyrazol-6-one MCHR1 antagonists for the treatment of obesity: Insights on in vivo efficacy from a novel FLIPR assay setup

Synthesis and SAR of 2,3,3a,4-tetrahydro-1H-pyrrolo[3,4-c]isoquinolin-5(9bH)-ones as 5-HT2C receptor agonists

A new and efficient synthetic route for the anxiolytic agent CL285032

The discovery of BMS-457, a potent and selective CCR1 antagonist

Synthesis and structure–activity relationships of novel indazolyl glucocorticoid receptor partial agonists

Investigation of the alkenyldiarylmethane non-nucleoside reverse transcriptase inhibitors as potential cAMP phosphodiesterase-4B2 inhibitors

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