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Organic Synthesis and Current Understanding of the Mechanisms of CFTR Modulator Drugs Ivacaftor, Tezacaftor, and Elexacaftor

Molecules (Basel, Switzerland), 2024-02, Vol.29 (4), p.821

2024

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N - tert -Butanesulfinyl imines in the asymmetric synthesis of nitrogen-containing heterocycles

Beilstein journal of organic chemistry, 2021-05, Vol.17 (1), p.1096-1140

2021

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Synthesis, characterization and crystal structure of methyl 2-(2-oxo-2 H -chromen-4-ylamino)benzoate

Acta crystallographica. Section E, Crystallographic communications, 2023-09, Vol.79 (9), p.842-846

2023

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Theoretical and experimental studies of new modified isoflavonoids as potential inhibitors of topoisomerase I from Plasmodium falciparum

PloS one, 2014-03, Vol.9 (3), p.e91191

2014

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11a-N-tosyl-5-carbapterocarpans: Synthesis, antineoplastic evaluation and in silico prediction of ADMETox properties

Bioorganic chemistry, 2018-10, Vol.80, p.585-590

2018

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Identification of novel F508del-CFTR traffic correctors among triazole derivatives

European journal of pharmacology, 2023-01, Vol.938, p.175396-175396, Article 175396

2023

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Design, synthesis, structural characterization and in vitro evaluation of new 1,4-disubstituted-1,2,3-triazole derivatives against glioblastoma cells

Bioorganic chemistry, 2019-03, Vol.83, p.87-97

2019

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Interaction between bioactive compound 11a-N-tosyl-5-deoxi-pterocarpan (LQB-223) and Calf thymus DNA: Spectroscopic approach, electrophoresis and theoretical studies

International journal of biological macromolecules, 2017-03, Vol.96, p.223-233

2017

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Additive Potentiation of R334W-CFTR Function by Novel Small Molecules

Journal of personalized medicine, 2023-01, Vol.13 (1), p.102

2023

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Synthesis and preliminary pharmacological evaluation of new (±) 1,4-naphthoquinones structurally related to lapachol

Bioorganic & medicinal chemistry, 2002-08, Vol.10 (8), p.2731-2738

2002

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Synthesis of 3-aryl-4-(N-aryl)aminocoumarins via photoredox arylation and the evaluation of their biological activity

Bioorganic chemistry, 2021-09, Vol.114, p.105141-105141, Article 105141

2021

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11a-N-Tosyl-5-deoxi-pterocarpan (LQB-223), a promising prototype for targeting MDR leukemia cell lines

European journal of medicinal chemistry, 2014-05, Vol.78, p.190-197

2014

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Pterocarpanquinones, aza-pterocarpanquinone and derivatives: Synthesis, antineoplasic activity on human malignant cell lines and antileishmanial activity on Leishmania amazonensis

Bioorganic & medicinal chemistry, 2011-11, Vol.19 (22), p.6885-6891

2011

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Molecular structure of tetraaqua adenosine 5′-triphosphate aluminium(III) complex: A study involving Raman spectroscopy, theoretical DFT and potentiometry

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 2013-03, Vol.105, p.88-101

2013

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Palladium-Catalyzed Oxyarylation, Azaarylation and α-Arylation Reactions in the Synthesis of Bioactive Isoflavonoid Analogues

Current organic synthesis, 2015-09, Vol.12 (6), p.772-794

2015

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Experimental and theoretical investigation of [Al(PCr)(H2O)] complex in aqueous solution

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 2014-01, Vol.118, p.260-270

2014

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Palladium-catalyzed oxyarylation of olefins using silver carbonate as the base. Probing the mechanism by electrospray ionization mass spectrometry

Journal of organometallic chemistry, 2010-08, Vol.695 (18), p.2062-2067

2010

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Structure–activity relationship of wedelolactone analogues: Structural requirements for inhibition of Na+,K+-ATPase and binding to the central benzodiazepine receptor

Bioorganic & medicinal chemistry, 2006-12, Vol.14 (23), p.7962-7966

2006

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Ability of a synthetic coumestan to antagonize Bothrops snake venom activities

Toxicon (Oxford), 2010-02, Vol.55 (2), p.488-496

2010

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1,3-Dipolar cycloaddition reactions of enaminones and azides: Synthesis of 4-acyl-1,2,3-triazoles and mechanistic studies

Tetrahedron, 2022-08, Vol.120, p.132856, Article 132856

2022

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Direct access of 4-acyl-1,2,3-triazoles from acetophenones: A synthetic shortcut for novel p.Phe508del-CFTR traffic correctors

Journal of molecular structure, 2025-02, Vol.1321, p.139897, Article 139897

2025

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Synthesis and preliminary pharmacological evaluation of coumestans with different patterns of oxygenation

Bioorganic & medicinal chemistry letters, 2001-02, Vol.11 (3), p.283-286

2001

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Synthesis, Photophysical and Electrochemical Properties of Novel D-π-D and D-π-A Triphenylamino-Chalcones and β-Arylchalcones

Journal of the Brazilian Chemical Society, 2019-01, Vol.30 (1), p.81-89

2019

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Theoretical Study of the Reactivity of Phenyl Radicals Toward Enol Acetates

Journal of the Brazilian Chemical Society, 2021-02, Vol.32 (2), p.395-404

2021

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New α-Hydroxy-1,2,3-triazoles and 9H-Fluorenes-1,2,3-triazoles: Synthesis and Evaluation as Glycine Transporter 1 Inhibitors

Journal of the Brazilian Chemical Society, 2020-06, Vol.31 (6), p.1258-1269

2020

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Organic Synthesis and Current Understanding of the Mechanisms of CFTR Modulator Drugs Ivacaftor, Tezacaftor, and Elexacaftor

N - tert -Butanesulfinyl imines in the asymmetric synthesis of nitrogen-containing heterocycles

Synthesis, characterization and crystal structure of methyl 2-(2-oxo-2 H -chromen-4-ylamino)benzoate

Theoretical and experimental studies of new modified isoflavonoids as potential inhibitors of topoisomerase I from Plasmodium falciparum

11a-N-tosyl-5-carbapterocarpans: Synthesis, antineoplastic evaluation and in silico prediction of ADMETox properties

Identification of novel F508del-CFTR traffic correctors among triazole derivatives

Design, synthesis, structural characterization and in vitro evaluation of new 1,4-disubstituted-1,2,3-triazole derivatives against glioblastoma cells

Interaction between bioactive compound 11a-N-tosyl-5-deoxi-pterocarpan (LQB-223) and Calf thymus DNA: Spectroscopic approach, electrophoresis and theoretical studies

Additive Potentiation of R334W-CFTR Function by Novel Small Molecules

Synthesis and preliminary pharmacological evaluation of new (±) 1,4-naphthoquinones structurally related to lapachol

Synthesis of 3-aryl-4-(N-aryl)aminocoumarins via photoredox arylation and the evaluation of their biological activity

11a-N-Tosyl-5-deoxi-pterocarpan (LQB-223), a promising prototype for targeting MDR leukemia cell lines

Pterocarpanquinones, aza-pterocarpanquinone and derivatives: Synthesis, antineoplasic activity on human malignant cell lines and antileishmanial activity on Leishmania amazonensis

Molecular structure of tetraaqua adenosine 5′-triphosphate aluminium(III) complex: A study involving Raman spectroscopy, theoretical DFT and potentiometry

Palladium-Catalyzed Oxyarylation, Azaarylation and α-Arylation Reactions in the Synthesis of Bioactive Isoflavonoid Analogues

Experimental and theoretical investigation of [Al(PCr)(H2O)] complex in aqueous solution

Palladium-catalyzed oxyarylation of olefins using silver carbonate as the base. Probing the mechanism by electrospray ionization mass spectrometry

Structure–activity relationship of wedelolactone analogues: Structural requirements for inhibition of Na+,K+-ATPase and binding to the central benzodiazepine receptor

Ability of a synthetic coumestan to antagonize Bothrops snake venom activities

1,3-Dipolar cycloaddition reactions of enaminones and azides: Synthesis of 4-acyl-1,2,3-triazoles and mechanistic studies

Direct access of 4-acyl-1,2,3-triazoles from acetophenones: A synthetic shortcut for novel p.Phe508del-CFTR traffic correctors

Synthesis and preliminary pharmacological evaluation of coumestans with different patterns of oxygenation

Synthesis, Photophysical and Electrochemical Properties of Novel D-π-D and D-π-A Triphenylamino-Chalcones and β-Arylchalcones

Theoretical Study of the Reactivity of Phenyl Radicals Toward Enol Acetates

New α-Hydroxy-1,2,3-triazoles and 9H-Fluorenes-1,2,3-triazoles: Synthesis and Evaluation as Glycine Transporter 1 Inhibitors

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