UB Paderborn / Katalog / Suche / in CDI

1 – 25 von 250

Sortiert nach

DYRK1A inhibitors for disease therapy: Current status and perspectives

European journal of medicinal chemistry, 2022-02, Vol.229, p.114062, Article 114062

2022

Link zum Volltext

Verfügbarkeit prüfen

Design, synthesis and evaluation of the first DYRK1A degraders for promoting the proliferation of pancreatic β-cells

Chinese chemical letters, 2024-02, p.109570, Article 109570

2024

Link zum Volltext

Verfügbarkeit prüfen

A Phase 2b randomized trial of lorecivivint, a novel intra-articular CLK2/DYRK1A inhibitor and Wnt pathway modulator for knee osteoarthritis

Osteoarthritis and cartilage, 2021-05, Vol.29 (5), p.654-666

2021

Link zum Volltext

Verfügbarkeit prüfen

QSAR modeling, molecular docking, ADMET prediction and molecular dynamics simulations of some 6-arylquinazolin-4-amine derivatives as DYRK1A inhibitors

Journal of molecular structure, 2022-06, Vol.1258, p.132659, Article 132659

2022

Link zum Volltext

Verfügbarkeit prüfen

Function and inhibition of DYRK1A: Emerging roles of treating multiple human diseases

Biochemical pharmacology, 2023-06, Vol.212, p.115521-115521, Article 115521

2023

Link zum Volltext

Verfügbarkeit prüfen

DYRK1A regulates the recruitment of 53BP1 to the sites of DNA damage in part through interaction with RNF169

Cell cycle (Georgetown, Tex.), 2019-03, Vol.18 (5), p.531-551

2019

Link zum Volltext

Verfügbarkeit prüfen

Modulation of the Wnt pathway through inhibition of CLK2 and DYRK1A by lorecivivint as a novel, potentially disease-modifying approach for knee osteoarthritis treatment

Osteoarthritis and cartilage, 2019-09, Vol.27 (9), p.1347-1360

2019

Link zum Volltext

Verfügbarkeit prüfen

Modification of histidine repeat proteins by inorganic polyphosphate

Cell reports (Cambridge), 2023-09, Vol.42 (9), p.113082-113082, Article 113082

2023

Link zum Volltext

Verfügbarkeit prüfen

Combined Inhibition of DYRK1A, SMAD, and Trithorax Pathways Synergizes to Induce Robust Replication in Adult Human Beta Cells

Cell metabolism, 2019-03, Vol.29 (3), p.638-652.e5

2019

Link zum Volltext

Verfügbarkeit prüfen

Corrigendum: Gut and spleen anomalies associated with DYRK1A syndrome

Frontiers in pediatrics, 2024, Vol.12, p.1372269-1372269

2024

Link zum Volltext

Verfügbarkeit prüfen

Neurogenesis impairment: An early developmental defect in Down syndrome

Free radical biology & medicine, 2018-01, Vol.114, p.15-32

2018

Link zum Volltext

Verfügbarkeit prüfen

Structural based study to identify new potential inhibitors for dual specificity tyrosine-phosphorylation- regulated kinase

Computer methods and programs in biomedicine, 2020-10, Vol.194, p.105494, Article 105494

2020

Link zum Volltext

Verfügbarkeit prüfen

Discovery of novel benzothiophene derivatives as potent and narrow spectrum inhibitors of DYRK1A and DYRK1B

Bioorganic & medicinal chemistry letters, 2022-07, Vol.68, p.128764-128764, Article 128764

2022

Link zum Volltext

Verfügbarkeit prüfen

DnaK promotes autophosphorylation of DYRK1A and its family kinases in Escherichia coli-based cell-free protein expression

Biochemical and biophysical research communications, 2023-12, Vol.688, p.149220-149220, Article 149220

2023

Link zum Volltext

Verfügbarkeit prüfen

LncRNA OIP5-AS1 regulates radioresistance by targeting DYRK1A through miR-369-3p in colorectal cancer cells

European journal of cell biology, 2018-06, Vol.97 (5), p.369-378

2018

Link zum Volltext

Verfügbarkeit prüfen

Dose imbalance of DYRK1A kinase causes systemic progeroid status in Down syndrome by increasing the un-repaired DNA damage and reducing LaminB1 levels

EBioMedicine, 2023-08, Vol.94, p.104692-104692, Article 104692

2023

Link zum Volltext

Verfügbarkeit prüfen

Aristolactam BIII, a naturally derived DYRK1A inhibitor, rescues Down syndrome-related phenotypes

Phytomedicine (Stuttgart), 2021-11, Vol.92, p.153695-153695, Article 153695

2021

Link zum Volltext

Verfügbarkeit prüfen

Imidazo[1,2-b]pyridazines as inhibitors of DYRK kinases

European journal of medicinal chemistry, 2024-04, Vol.269, p.116292-116292, Article 116292

2024

Link zum Volltext

Verfügbarkeit prüfen

Identification of two novel and one rare mutation in DYRK1A and prenatal diagnoses in three Chinese families with intellectual Disability-7

Frontiers in genetics, 2023-12, Vol.14, p.1290949-1290949

2023

Link zum Volltext

Verfügbarkeit prüfen

Design, synthesis and biological evaluation of harmine derivatives as potent GSK-3β/DYRK1A dual inhibitors for the treatment of Alzheimer's disease

European journal of medicinal chemistry, 2021-10, Vol.222, p.113554, Article 113554

2021

Link zum Volltext

Verfügbarkeit prüfen

DYRK1A in neurodegeneration and cancer: Molecular basis and clinical implications

Pharmacology & therapeutics (Oxford), 2015-07, Vol.151, p.87-98

2015

Link zum Volltext

Verfügbarkeit prüfen

Optimization and validation of a DYRK1A TR-FRET assay for high-throughput screening

MethodsX, 2021-01, Vol.8, p.101383-101383, Article 101383

2021

Link zum Volltext

Verfügbarkeit prüfen

Dyrk1a Mutations Cause Undergrowth of Cortical Pyramidal Neurons via Dysregulated Growth Factor Signaling

Biological psychiatry (1969), 2021-09, Vol.90 (5), p.295-306

2021

Link zum Volltext

Verfügbarkeit prüfen

The novel DYRK1A inhibitor KVN93 regulates cognitive function, amyloid-beta pathology, and neuroinflammation

Free radical biology & medicine, 2020-11, Vol.160, p.575-595

2020

Link zum Volltext

Verfügbarkeit prüfen

1 – 25 von 250

Suche als RSS-Feed

Aktive Filter

KollektionIngenta

Suchergebnisse filtern

Filter anzeigen

Nur zeigen

Geprüft (Peer-Review)
(244)
Mit Volltextzugriff
(239)

Publikationsform

Sprache

Englisch
(249)
Japanisch
(45)
Deutsch
(1)

Erscheinungsjahr

n.n

Thema

Science & Technology
(229)
Life Sciences & Biomedicine
(224)
Dyrk1a
(211)
Dyrk Kinases
(153)
Humans
(134)
Animals
(116)
Protein-Tyrosine Kinases - Metabolism
(90)
Protein Serine-Threonine Kinases - Metabolism
(88)
Down Syndrome
(77)
Protein Serine-Threonine Kinases - Genetics
(74)
Phosphorylation
(72)
Protein-Tyrosine Kinases - Genetics
(72)
Mice
(71)
Protein-Tyrosine Kinases - Antagonists & Inhibitors
(64)
Protein Serine-Threonine Kinases - Antagonists & Inhibitors
(62)
Pharmacology & Pharmacy
(60)
Biochemistry & Molecular Biology
(58)
Neurosciences
(53)
Neurosciences & Neurology
(53)
Kinases
(50)

15 weitere anzeigen...

Weniger anzeigen...

Neu hinzugefügt

... seit 90 Tagen
(2)

Menü

Weitere Dienste

Einstellungen

DYRK1A inhibitors for disease therapy: Current status and perspectives

Design, synthesis and evaluation of the first DYRK1A degraders for promoting the proliferation of pancreatic β-cells

A Phase 2b randomized trial of lorecivivint, a novel intra-articular CLK2/DYRK1A inhibitor and Wnt pathway modulator for knee osteoarthritis

QSAR modeling, molecular docking, ADMET prediction and molecular dynamics simulations of some 6-arylquinazolin-4-amine derivatives as DYRK1A inhibitors

Function and inhibition of DYRK1A: Emerging roles of treating multiple human diseases

DYRK1A regulates the recruitment of 53BP1 to the sites of DNA damage in part through interaction with RNF169

Modulation of the Wnt pathway through inhibition of CLK2 and DYRK1A by lorecivivint as a novel, potentially disease-modifying approach for knee osteoarthritis treatment

Modification of histidine repeat proteins by inorganic polyphosphate

Combined Inhibition of DYRK1A, SMAD, and Trithorax Pathways Synergizes to Induce Robust Replication in Adult Human Beta Cells

Corrigendum: Gut and spleen anomalies associated with DYRK1A syndrome

Safety and efficacy of cognitive training plus epigallocatechin-3-gallate in young adults with Down's syndrome (TESDAD): a double-blind, randomised, placebo-controlled, phase 2 trial

Neurogenesis impairment: An early developmental defect in Down syndrome

Structural based study to identify new potential inhibitors for dual specificity tyrosine-phosphorylation- regulated kinase

Discovery of novel benzothiophene derivatives as potent and narrow spectrum inhibitors of DYRK1A and DYRK1B

DnaK promotes autophosphorylation of DYRK1A and its family kinases in Escherichia coli-based cell-free protein expression

LncRNA OIP5-AS1 regulates radioresistance by targeting DYRK1A through miR-369-3p in colorectal cancer cells

Dose imbalance of DYRK1A kinase causes systemic progeroid status in Down syndrome by increasing the un-repaired DNA damage and reducing LaminB1 levels

Aristolactam BIII, a naturally derived DYRK1A inhibitor, rescues Down syndrome-related phenotypes

Imidazo[1,2-b]pyridazines as inhibitors of DYRK kinases

Identification of two novel and one rare mutation in DYRK1A and prenatal diagnoses in three Chinese families with intellectual Disability-7

Design, synthesis and biological evaluation of harmine derivatives as potent GSK-3β/DYRK1A dual inhibitors for the treatment of Alzheimer's disease

DYRK1A in neurodegeneration and cancer: Molecular basis and clinical implications

Optimization and validation of a DYRK1A TR-FRET assay for high-throughput screening

Dyrk1a Mutations Cause Undergrowth of Cortical Pyramidal Neurons via Dysregulated Growth Factor Signaling

The novel DYRK1A inhibitor KVN93 regulates cognitive function, amyloid-beta pathology, and neuroinflammation

Aktive Filter

Suchergebnisse filtern