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Evaluation of Nitrobenzyl Derivatives of Camptothecin as Anti-Cancer Agents and Potential Hypoxia Targeting Prodrugs

Molecules (Basel, Switzerland), 2018-08, Vol.23 (8), p.2041

2018

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A QSAR study that compares the ability of bisdioxopiperazine analogs of the doxorubicin cardioprotective agent dexrazoxane (ICRF-187) to protect myocytes with DNA topoisomerase II inhibition

Toxicology and applied pharmacology, 2020-07, Vol.399, p.115038, Article 115038

2020

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Progress curve analysis of the kinetics of slow-binding anticancer drug inhibitors of the 20S proteasome

Archives of biochemistry and biophysics, 2018-02, Vol.639, p.52-58

Hasinoff, Brian B.

2018

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The cardiotoxicity and myocyte damage caused by small molecule anticancer tyrosine kinase inhibitors is correlated with lack of target specificity

Toxicology and applied pharmacology, 2010-04, Vol.244 (2), p.190-195

Hasinoff, Brian B.

2010

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The lack of target specificity of small molecule anticancer kinase inhibitors is correlated with their ability to damage myocytes in vitro

Toxicology and applied pharmacology, 2010-12, Vol.249 (2), p.132-139

2010

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Disulfiram is a slow-binding partial noncompetitive inhibitor of 20S proteasome activity

Archives of biochemistry and biophysics, 2017-11, Vol.633, p.23-28

2017

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A diazirine-based photoaffinity etoposide probe for labeling topoisomerase II

Bioorganic & medicinal chemistry, 2010-01, Vol.18 (2), p.830-838

2010

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The cytotoxicity of the anticancer drug elesclomol is due to oxidative stress indirectly mediated through its complex with Cu(II)

Journal of inorganic biochemistry, 2014-08, Vol.137, p.22-30

2014

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Molecular mechanisms of the biological activity of the anticancer drug elesclomol and its complexes with Cu(II), Ni(II) and Pt(II)

Journal of inorganic biochemistry, 2013-09, Vol.126, p.1-6

2013

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Mechanism of the cytotoxicity of the diazoparaquinone antitumor antibiotic kinamycin F

Free radical biology & medicine, 2007-10, Vol.43 (8), p.1132-1144

2007

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Cellular mechanisms of the cytotoxicity of the anticancer drug elesclomol and its complex with Cu(II)

Biochemical pharmacology, 2015-02, Vol.93 (3), p.266-276

2015

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The anticancer multi-kinase inhibitor dovitinib also targets topoisomerase I and topoisomerase II

Biochemical pharmacology, 2012-12, Vol.84 (12), p.1617-1626

2012

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The anticancer thiosemicarbazones Dp44mT and triapine lack inhibitory effects as catalytic inhibitors or poisons of DNA topoisomerase IIα

Biochemical pharmacology, 2012-07, Vol.84 (1), p.52-58

2012

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Structure-based design, synthesis and biological testing of etoposide analog epipodophyllotoxin–N-mustard hybrid compounds designed to covalently bind to topoisomerase II and DNA

Bioorganic & medicinal chemistry, 2014-11, Vol.22 (21), p.5935-5949

2014

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Class-1 hemoglobins, nitrate and NO levels in anoxic maize cell-suspension cultures

Planta, 2004-05, Vol.219 (1), p.66-72

2004

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Structure-based design, synthesis and biological testing of piperazine-linked bis-epipodophyllotoxin etoposide analogs

Bioorganic & medicinal chemistry, 2015-07, Vol.23 (13), p.3542-3551

2015

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Cadmium is a catalytic inhibitor of DNA topoisomerase II

Journal of inorganic biochemistry, 2011-06, Vol.105 (6), p.833-838

2011

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The oral iron chelator ICL670A (deferasirox) does not protect myocytes against doxorubicin

Free radical biology & medicine, 2003-12, Vol.35 (11), p.1469-1479

2003

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Design, synthesis, and biological evaluation of a novel series of bisintercalating DNA-binding piperazine-linked bisanthrapyrazole compounds as anticancer agents

Bioorganic & medicinal chemistry, 2011-12, Vol.19 (23), p.7023-7032

2011

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The intracellular iron sensor calcein is catalytically oxidatively degraded by iron(II) in a hydrogen peroxide-dependent reaction

Journal of inorganic biochemistry, 2003-06, Vol.95 (2), p.157-164

Hasinoff, Brian B.

2003

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The iron chelator Dp44mT does not protect myocytes against doxorubicin

Journal of inorganic biochemistry, 2009-07, Vol.103 (7), p.1093-1101

2009

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A review of the preclinical development of dexrazoxane

Progress in pediatric cardiology, 2014-09, Vol.36 (1), p.33-38

2014

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Deferiprone protects against doxorubicin-induced myocyte cytotoxicity

Free radical biology & medicine, 2002-07, Vol.33 (2), p.266-275

2002

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High-throughput fluorescence flow-injection topoisomerase II inhibition assay

Journal of chromatography. B, Biomedical sciences and applications, 2001-09, Vol.760 (2), p.263-269

2001

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Kinamycin F downregulates cyclin D3 in human leukemia K562 cells

Chemico-biological interactions, 2010-03, Vol.184 (3), p.396-402

2010

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Evaluation of Nitrobenzyl Derivatives of Camptothecin as Anti-Cancer Agents and Potential Hypoxia Targeting Prodrugs

A QSAR study that compares the ability of bisdioxopiperazine analogs of the doxorubicin cardioprotective agent dexrazoxane (ICRF-187) to protect myocytes with DNA topoisomerase II inhibition

Progress curve analysis of the kinetics of slow-binding anticancer drug inhibitors of the 20S proteasome

The cardiotoxicity and myocyte damage caused by small molecule anticancer tyrosine kinase inhibitors is correlated with lack of target specificity

The lack of target specificity of small molecule anticancer kinase inhibitors is correlated with their ability to damage myocytes in vitro

Disulfiram is a slow-binding partial noncompetitive inhibitor of 20S proteasome activity

A diazirine-based photoaffinity etoposide probe for labeling topoisomerase II

The cytotoxicity of the anticancer drug elesclomol is due to oxidative stress indirectly mediated through its complex with Cu(II)

Molecular mechanisms of the biological activity of the anticancer drug elesclomol and its complexes with Cu(II), Ni(II) and Pt(II)

Mechanism of the cytotoxicity of the diazoparaquinone antitumor antibiotic kinamycin F

Cellular mechanisms of the cytotoxicity of the anticancer drug elesclomol and its complex with Cu(II)

The anticancer multi-kinase inhibitor dovitinib also targets topoisomerase I and topoisomerase II

The anticancer thiosemicarbazones Dp44mT and triapine lack inhibitory effects as catalytic inhibitors or poisons of DNA topoisomerase IIα

Structure-based design, synthesis and biological testing of etoposide analog epipodophyllotoxin–N-mustard hybrid compounds designed to covalently bind to topoisomerase II and DNA

Class-1 hemoglobins, nitrate and NO levels in anoxic maize cell-suspension cultures

Structure-based design, synthesis and biological testing of piperazine-linked bis-epipodophyllotoxin etoposide analogs

Cadmium is a catalytic inhibitor of DNA topoisomerase II

The oral iron chelator ICL670A (deferasirox) does not protect myocytes against doxorubicin

Design, synthesis, and biological evaluation of a novel series of bisintercalating DNA-binding piperazine-linked bisanthrapyrazole compounds as anticancer agents

The intracellular iron sensor calcein is catalytically oxidatively degraded by iron(II) in a hydrogen peroxide-dependent reaction

The iron chelator Dp44mT does not protect myocytes against doxorubicin

A review of the preclinical development of dexrazoxane

Deferiprone protects against doxorubicin-induced myocyte cytotoxicity

High-throughput fluorescence flow-injection topoisomerase II inhibition assay

Kinamycin F downregulates cyclin D3 in human leukemia K562 cells

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