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The Thiol-polyamine Metabolism of Trypanosoma cruzi: Molecular Targets and Drug Repurposing Strategies

Current medicinal chemistry, 2019-01, Vol.26 (36), p.6614-6635

2019

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Glucose-6-Phosphate Dehydrogenase from the Human Pathogen Trypanosoma cruzi Evolved Unique Structural Features to Support Efficient Product Formation

Journal of molecular biology, 2019-05, Vol.431 (11), p.2143-2162

2019

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Drugging the Undruggable Trypanosoma brucei Monothiol Glutaredoxin 1

Molecules (Basel, Switzerland), 2023-01, Vol.28 (3), p.1276

2023

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Novel distamycin analogues that block the cell cycle of African trypanosomes with high selectivity and potency

European journal of medicinal chemistry, 2020-03, Vol.189, p.112043, Article 112043

2020

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Redox control in trypanosomatids, parasitic protozoa with trypanothione-based thiol metabolism

Biochimica et biophysica acta, 2008-11, Vol.1780 (11), p.1236-1248

2008

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Alternative Thiol-Based Redox Systems

Antioxidants & redox signaling, 2018-02, Vol.28 (6), p.407-409

2018

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Generation and Characterization of Stable Redox-Reporter Mammalian Cell Lines of Biotechnological Relevance

Sensors (Basel, Switzerland), 2022-02, Vol.22 (4), p.1324

2022

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Discovery of novel Leishmania major trypanothione synthetase inhibitors by high-throughput screening

Biochemical and biophysical research communications, 2022-12, Vol.637, p.308-313

2022

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The indole motif is essential for the antitrypanosomal activity of N5-substituted paullones

PloS one, 2023-11, Vol.18 (11), p.e0292946-e0292946

2023

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Glucose 6-Phosphate Dehydrogenase from Trypanosomes: Selectivity for Steroids and Chemical Validation in Bloodstream Trypanosoma brucei

Molecules (Basel, Switzerland), 2021-01, Vol.26 (2), p.358

2021

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Identification of Novel Chemical Scaffolds Inhibiting Trypanothione Synthetase from Pathogenic Trypanosomatids

PLoS neglected tropical diseases, 2016-04, Vol.10 (4), p.e0004617-e0004617

2016

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An essential thioredoxin-type protein of Trypanosoma brucei acts as redox-regulated mitochondrial chaperone

PLoS pathogens, 2019-09, Vol.15 (9), p.e1008065-e1008065

2019

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Polyamine-Based Thiols in Trypanosomatids: Evolution, Protein Structural Adaptations, and Biological Functions

Antioxidants & redox signaling, 2018-02, Vol.28 (6), p.463-486

2018

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Binding Mode and Selectivity of Steroids towards Glucose-6-phosphate Dehydrogenase from the Pathogen Trypanosoma cruzi

Molecules (Basel, Switzerland), 2016-03, Vol.21 (3), p.368

2016

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Murine colon organoids as a novel model to study Trypanosoma cruzi infection and interactions with the intestinal epithelium

Frontiers in cellular and infection microbiology, 2023-03, Vol.13, p.1082524-1082524

2023

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Mono- and dithiol glutaredoxins in the trypanothione-based redox metabolism of pathogenic trypanosomes

Antioxidants & redox signaling, 2013-09, Vol.19 (7), p.708-722

2013

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Cytosolic peroxidases protect the lysosome of bloodstream African trypanosomes from iron-mediated membrane damage

PLoS pathogens, 2014-04, Vol.10 (4), p.e1004075-e1004075

2014

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In vitro activity and mode of action of distamycin analogues against African trypanosomes

European journal of medicinal chemistry, 2017-01, Vol.126, p.776-788

2017

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Determination of acidity and nucleophilicity in thiols by reaction with monobromobimane and fluorescence detection

Analytical biochemistry, 2013-04, Vol.435 (1), p.74-82

2013

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Selenosugars targeting the infective stage of Trypanosoma brucei with high selectivity

International journal for parasitology -- drugs and drug resistance, 2024-04, Vol.24, p.100529-100529, Article 100529

2024

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Mode of action of p-quinone derivatives with trypanocidal activity studied by experimental and in silico models

European journal of medicinal chemistry, 2023-01, Vol.246, p.114926-114926, Article 114926

2023

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Insights into the redox biology of Trypanosoma cruzi: Trypanothione metabolism and oxidant detoxification

Free radical biology & medicine, 2008-09, Vol.45 (6), p.733-742

2008

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Nox2-derived superoxide radical is crucial to control acute Trypanosoma cruzi infection

Redox biology, 2021-10, Vol.46, p.102085-102085, Article 102085

2021

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Trypanothione synthetase confers growth, survival advantage and resistance to anti-protozoal drugs in Trypanosoma cruzi

Free radical biology & medicine, 2019-01, Vol.130, p.23-34

2019

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Iron-sulfur cluster binding by mitochondrial monothiol glutaredoxin-1 of Trypanosoma brucei: molecular basis of iron-sulfur cluster coordination and relevance for parasite infectivity

Antioxidants & redox signaling, 2013-09, Vol.19 (7), p.665-682

2013

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The Thiol-polyamine Metabolism of Trypanosoma cruzi: Molecular Targets and Drug Repurposing Strategies

Glucose-6-Phosphate Dehydrogenase from the Human Pathogen Trypanosoma cruzi Evolved Unique Structural Features to Support Efficient Product Formation

Drugging the Undruggable Trypanosoma brucei Monothiol Glutaredoxin 1

Novel distamycin analogues that block the cell cycle of African trypanosomes with high selectivity and potency

Redox control in trypanosomatids, parasitic protozoa with trypanothione-based thiol metabolism

Alternative Thiol-Based Redox Systems

Generation and Characterization of Stable Redox-Reporter Mammalian Cell Lines of Biotechnological Relevance

Discovery of novel Leishmania major trypanothione synthetase inhibitors by high-throughput screening

The indole motif is essential for the antitrypanosomal activity of N5-substituted paullones

Glucose 6-Phosphate Dehydrogenase from Trypanosomes: Selectivity for Steroids and Chemical Validation in Bloodstream Trypanosoma brucei

Identification of Novel Chemical Scaffolds Inhibiting Trypanothione Synthetase from Pathogenic Trypanosomatids

An essential thioredoxin-type protein of Trypanosoma brucei acts as redox-regulated mitochondrial chaperone

Polyamine-Based Thiols in Trypanosomatids: Evolution, Protein Structural Adaptations, and Biological Functions

Binding Mode and Selectivity of Steroids towards Glucose-6-phosphate Dehydrogenase from the Pathogen Trypanosoma cruzi

Murine colon organoids as a novel model to study Trypanosoma cruzi infection and interactions with the intestinal epithelium

Mono- and dithiol glutaredoxins in the trypanothione-based redox metabolism of pathogenic trypanosomes

Cytosolic peroxidases protect the lysosome of bloodstream African trypanosomes from iron-mediated membrane damage

In vitro activity and mode of action of distamycin analogues against African trypanosomes

Determination of acidity and nucleophilicity in thiols by reaction with monobromobimane and fluorescence detection

Selenosugars targeting the infective stage of Trypanosoma brucei with high selectivity

Mode of action of p-quinone derivatives with trypanocidal activity studied by experimental and in silico models

Insights into the redox biology of Trypanosoma cruzi: Trypanothione metabolism and oxidant detoxification

Nox2-derived superoxide radical is crucial to control acute Trypanosoma cruzi infection

Trypanothione synthetase confers growth, survival advantage and resistance to anti-protozoal drugs in Trypanosoma cruzi

Iron-sulfur cluster binding by mitochondrial monothiol glutaredoxin-1 of Trypanosoma brucei: molecular basis of iron-sulfur cluster coordination and relevance for parasite infectivity

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