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Designer genetically encoded voltage‐dependent calcium channel inhibitors inspired by RGK GTPases

The Journal of physiology, 2020-05, Vol.598 (9), p.1683-1693

Colecraft, Henry M.

2020

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Inhibition of NAPDH Oxidase 2 (NOX2) Prevents Oxidative Stress and Mitochondrial Abnormalities Caused by Saturated Fat in Cardiomyocytes

PloS one, 2016-01, Vol.11 (1), p.e0145750-e0145750

2016

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Serotonin-reuptake inhibitors act centrally to cause bone loss in mice by counteracting a local anti-resorptive effect

Nature medicine, 2016-10, Vol.22 (10), p.1170-1179

2016

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Distinct RGK GTPases differentially use α1- and auxiliary β-binding-dependent mechanisms to inhibit CaV1.2/CaV2.2 channels

PloS one, 2012-05, Vol.7 (5), p.e37079-e37079

2012

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Potassium channels in the heart: structure, function and regulation

The Journal of physiology, 2017-04, Vol.595 (7), p.2209-2228

2017

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High-fat diet-dependent modulation of the delayed rectifier K+ current in adult guinea pig atrial myocytes

Biochemical and biophysical research communications, 2016-06, Vol.474 (3), p.554-559

2016

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Mitochondrial oxidative stress during cardiac lipid overload causes intracellular calcium leak and arrhythmia

Heart rhythm, 2016-08, Vol.13 (8), p.1699-1706

2016

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BIN1 localizes the L-type calcium channel to cardiac T-tubules

PLoS biology, 2010-02, Vol.8 (2), p.e1000312-e1000312

2010

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Regulation of Blood Pressure by Targeting CaV1.2-Galectin-1 Protein Interaction

Circulation (New York, N.Y.), 2018-10, Vol.138 (14), p.1431-1445

2018

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Development of a High-Throughput Flow Cytometry Assay to Monitor Defective Trafficking and Rescue of Long QT2 Mutant hERG Channels

Frontiers in physiology, 2018-04, Vol.9, p.397-397

2018

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LQT1 mutations in KCNQ1 C-terminus assembly domain suppress IKs using different mechanisms

Cardiovascular research, 2014-12, Vol.104 (3), p.501-511

2014

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Transfer RNA-mediated restoration of potassium current and electrical correction in premature termination long-QT syndrome hERG mutants

Molecular therapy. Nucleic acids, 2023-12, Vol.34, p.102032, Article 102032

2023

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Perturbation of the host cell Ca2+ homeostasis and ER-mitochondria contact sites by the SARS-CoV-2 structural proteins E and M

Cell death & disease, 2023-04, Vol.14 (4), p.297-297, Article 297

2023

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Pharmacological rescue of specific long QT variants of KCNQ1/KCNE1 channels

Frontiers in physiology, 2022-11, Vol.13, p.902224-902224

2022

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Research Highlights: Biophysics of Calcium

Biophysical journal, 2020-10, Vol.119 (8), p.1472-1473

Colecraft, Henry M.

2020

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David T. Yue: In Memoriam

Neuron (Cambridge, Mass.), 2015-03, Vol.85 (6), p.1158-1161

2015

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Molecular Mechanisms, and Selective Pharmacological Rescue, of Rem-Inhibited CaV1.2 Channels in Heart

Circulation research, 2010-09, Vol.107 (5), p.620-630

2010

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hERG 1a LQT2 C-terminus truncation mutants display hERG 1b-dependent dominant negative mechanisms

Heart rhythm, 2016-05, Vol.13 (5), p.1121-1130

2016

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Regulation of voltage-dependent calcium channels by RGK proteins

Biochimica et biophysica acta, 2013-07, Vol.1828 (7), p.1644-1654

2013

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Correction: Inhibition of NAPDH Oxidase 2 (NOX2) Prevents Oxidative Stress and Mitochondrial Abnormalities Caused by Saturated Fat in Cardiomyocytes

PloS one, 2017-03, Vol.12 (3), p.e0174525-e0174525

2017

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L-type calcium channel targeting and local signalling in cardiac myocytes

Cardiovascular research, 2013-05, Vol.98 (2), p.177-186

2013

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Ion Channel Engineering: Perspectives and Strategies

Journal of molecular biology, 2015-01, Vol.427 (1), p.190-204

2015

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Controlling ion channel function with renewable recombinant antibodies

The Journal of physiology, 2022-05, Vol.600 (9), p.2023-2036

2022

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Mechanism of auxiliary β‐subunit‐mediated membrane targeting of L‐type (CaV1.2) channels

The Journal of physiology, 2011-09, Vol.589 (18), p.4437-4455

2011

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Mechanism of auxiliary β-subunit-mediated membrane targeting of L-type (Ca(V)1.2) channels

The Journal of physiology, 2011-09, Vol.589 (Pt 18), p.4437

2011

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Designer genetically encoded voltage‐dependent calcium channel inhibitors inspired by RGK GTPases

Inhibition of NAPDH Oxidase 2 (NOX2) Prevents Oxidative Stress and Mitochondrial Abnormalities Caused by Saturated Fat in Cardiomyocytes

Serotonin-reuptake inhibitors act centrally to cause bone loss in mice by counteracting a local anti-resorptive effect

Distinct RGK GTPases differentially use α1- and auxiliary β-binding-dependent mechanisms to inhibit CaV1.2/CaV2.2 channels

Potassium channels in the heart: structure, function and regulation

High-fat diet-dependent modulation of the delayed rectifier K+ current in adult guinea pig atrial myocytes

Mitochondrial oxidative stress during cardiac lipid overload causes intracellular calcium leak and arrhythmia

BIN1 localizes the L-type calcium channel to cardiac T-tubules

Regulation of Blood Pressure by Targeting CaV1.2-Galectin-1 Protein Interaction

Development of a High-Throughput Flow Cytometry Assay to Monitor Defective Trafficking and Rescue of Long QT2 Mutant hERG Channels

LQT1 mutations in KCNQ1 C-terminus assembly domain suppress IKs using different mechanisms

Transfer RNA-mediated restoration of potassium current and electrical correction in premature termination long-QT syndrome hERG mutants

Perturbation of the host cell Ca2+ homeostasis and ER-mitochondria contact sites by the SARS-CoV-2 structural proteins E and M

Pharmacological rescue of specific long QT variants of KCNQ1/KCNE1 channels

Research Highlights: Biophysics of Calcium

David T. Yue: In Memoriam

Molecular Mechanisms, and Selective Pharmacological Rescue, of Rem-Inhibited CaV1.2 Channels in Heart

hERG 1a LQT2 C-terminus truncation mutants display hERG 1b-dependent dominant negative mechanisms

Regulation of voltage-dependent calcium channels by RGK proteins

Correction: Inhibition of NAPDH Oxidase 2 (NOX2) Prevents Oxidative Stress and Mitochondrial Abnormalities Caused by Saturated Fat in Cardiomyocytes

L-type calcium channel targeting and local signalling in cardiac myocytes

Ion Channel Engineering: Perspectives and Strategies

Controlling ion channel function with renewable recombinant antibodies

Mechanism of auxiliary β‐subunit‐mediated membrane targeting of L‐type (CaV1.2) channels

Mechanism of auxiliary β-subunit-mediated membrane targeting of L-type (Ca(V)1.2) channels

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