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Distinct p53 Transcriptional Programs Dictate Acute DNA-Damage Responses and Tumor Suppression

Cell, 2011-05, Vol.145 (4), p.571-583

2011

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Prion-like aggregation of mutant p53 in cancer

Trends in biochemical sciences (Amsterdam. Regular ed.), 2014-06, Vol.39 (6), p.260-267

2014

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How mutations shape p53 interactions with the genome to promote tumorigenesis and drug resistance

Drug resistance updates, 2018-05, Vol.38, p.27-43

2018

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Acetylation Is Indispensable for p53 Activation

Cell, 2008-05, Vol.133 (4), p.612-626

2008

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Structural Adaptation of Secondary p53 Binding Sites on MDM2 and MDMX

Journal of molecular biology, 2024-07, Vol.436 (13), p.168626, Article 168626

2024

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The Tail That Wags the Dog: How the Disordered C-Terminal Domain Controls the Transcriptional Activities of the p53 Tumor-Suppressor Protein

Trends in biochemical sciences (Amsterdam. Regular ed.), 2016-12, Vol.41 (12), p.1022-1034

2016

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PMSPcnn: Predicting protein stability changes upon single point mutations with convolutional neural network

Structure (London), 2024-06, Vol.32 (6), p.838-848.e3

2024

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Angiogenic factor AGGF1 acts as a tumor suppressor by modulating p53 post-transcriptional modifications and stability via MDM2

Cancer letters, 2021-01, Vol.497, p.28-40

2021

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p53 stability is regulated by diverse deubiquitinating enzymes

Biochimica et biophysica acta. Reviews on cancer, 2017-12, Vol.1868 (2), p.404-411

2017

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Co-localization of mutant p53 and amyloid-like protein aggregates in breast tumors

The international journal of biochemistry & cell biology, 2011, Vol.43 (1), p.60-64

2011

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Investigation of the MDM2-binding potential of de novo designed peptides using enhanced sampling simulations

International journal of biological macromolecules, 2024-06, Vol.269 (Pt 2), p.131840-131840, Article 131840

2024

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The MDMX Acidic Domain Uses Allovalency to Bind Both p53 and MDMX

Journal of molecular biology, 2022-11, Vol.434 (22), p.167844-167844, Article 167844

2022

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The disordered DNA-binding domain of p53 is indispensable for forming an encounter complex to and jumping along DNA

Biochemical and biophysical research communications, 2021-01, Vol.534, p.21-26

2021

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Exploiting Transient Protein States for the Design of Small-Molecule Stabilizers of Mutant p53

Structure (London), 2015-12, Vol.23 (12), p.2246-2255

2015

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Intrinsically Disordered N-terminal Domain (NTD) of p53 Interacts with Mitochondrial PTP Regulator Cyclophilin D

Journal of molecular biology, 2022-05, Vol.434 (9), p.167552, Article 167552

2022

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Solution Structure Analysis of the HPV16 E6 Oncoprotein Reveals a Self-Association Mechanism Required for E6-Mediated Degradation of p53

Structure (London), 2012-04, Vol.20 (4), p.604-617

2012

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Crotonylation at serine 46 impairs p53 activity

Biochemical and biophysical research communications, 2020-04, Vol.524 (3), p.730-735

2020

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Modulation of p53 and prion protein aggregation by RNA

Biochimica et biophysica acta. Proteins and proteomics, 2019-10, Vol.1867 (10), p.933-940

2019

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Reactivation of p53: from peptides to small molecules

Trends in pharmacological sciences (Regular ed.), 2011-01, Vol.32 (1), p.53-62

2011

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Interaction of p53 with prolyl isomerases: Healthy and unhealthy relationships

Biochimica et biophysica acta, 2015-10, Vol.1850 (10), p.2048-2060

2015

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One-Dimensional Sliding of p53 Along DNA Is Accelerated in the Presence of Ca(2+) or Mg(2+) at Millimolar Concentrations

Journal of molecular biology, 2015-08, Vol.427 (16), p.2663-2678

2015

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HMGB1-Facilitated p53 DNA Binding Occurs via HMG-Box/p53 Transactivation Domain Interaction, Regulated by the Acidic Tail

Structure (London), 2012-12, Vol.20 (12), p.2014-2024

2012

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Trichostatin A inhibits deacetylation of histone H3 and p53 by SIRT6

Archives of biochemistry and biophysics, 2018-01, Vol.638, p.8-17

2018

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Electrochemical sensing of tumor suppressor protein p53–deoxyribonucleic acid complex stability at an electrified interface

Analytica chimica acta, 2014-05, Vol.828, p.1-8

2014

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Systematic Mutational Analysis of Peptide Inhibition of the p53–MDM2/MDMX Interactions

Journal of molecular biology, 2010-04, Vol.398 (2), p.200-213

2010

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Distinct p53 Transcriptional Programs Dictate Acute DNA-Damage Responses and Tumor Suppression

Prion-like aggregation of mutant p53 in cancer

How mutations shape p53 interactions with the genome to promote tumorigenesis and drug resistance

Acetylation Is Indispensable for p53 Activation

Structural Adaptation of Secondary p53 Binding Sites on MDM2 and MDMX

The Tail That Wags the Dog: How the Disordered C-Terminal Domain Controls the Transcriptional Activities of the p53 Tumor-Suppressor Protein

PMSPcnn: Predicting protein stability changes upon single point mutations with convolutional neural network

Angiogenic factor AGGF1 acts as a tumor suppressor by modulating p53 post-transcriptional modifications and stability via MDM2

p53 stability is regulated by diverse deubiquitinating enzymes

Co-localization of mutant p53 and amyloid-like protein aggregates in breast tumors

Investigation of the MDM2-binding potential of de novo designed peptides using enhanced sampling simulations

The MDMX Acidic Domain Uses Allovalency to Bind Both p53 and MDMX

The disordered DNA-binding domain of p53 is indispensable for forming an encounter complex to and jumping along DNA

Exploiting Transient Protein States for the Design of Small-Molecule Stabilizers of Mutant p53

Intrinsically Disordered N-terminal Domain (NTD) of p53 Interacts with Mitochondrial PTP Regulator Cyclophilin D

Solution Structure Analysis of the HPV16 E6 Oncoprotein Reveals a Self-Association Mechanism Required for E6-Mediated Degradation of p53

Crotonylation at serine 46 impairs p53 activity

Modulation of p53 and prion protein aggregation by RNA

Reactivation of p53: from peptides to small molecules

Interaction of p53 with prolyl isomerases: Healthy and unhealthy relationships

One-Dimensional Sliding of p53 Along DNA Is Accelerated in the Presence of Ca(2+) or Mg(2+) at Millimolar Concentrations

HMGB1-Facilitated p53 DNA Binding Occurs via HMG-Box/p53 Transactivation Domain Interaction, Regulated by the Acidic Tail

Trichostatin A inhibits deacetylation of histone H3 and p53 by SIRT6

Electrochemical sensing of tumor suppressor protein p53–deoxyribonucleic acid complex stability at an electrified interface

Systematic Mutational Analysis of Peptide Inhibition of the p53–MDM2/MDMX Interactions

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