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Targeting CDK4 and CDK6: From Discovery to Therapy

Cancer discovery, 2016-04, Vol.6 (4), p.353-367

2016

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NK cell-mediated cytotoxicity contributes to tumor control by a cytostatic drug combination

Science (American Association for the Advancement of Science), 2018-12, Vol.362 (6421), p.1416-1422

2018

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CDK9-mediated transcription elongation is required for MYC addiction in hepatocellular carcinoma

Genes & development, 2014-08, Vol.28 (16), p.1800-1814

2014

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Cancer Cell Cycles

Science (American Association for the Advancement of Science), 1996-12, Vol.274 (5293), p.1672-1677

Sherr, Charles J.

1996

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Arf Gene Loss Enhances Oncogenicity and Limits Imatinib Response in Mouse Models of Bcr-Abl-Induced Acute Lymphoblastic Leukemia

Proceedings of the National Academy of Sciences - PNAS, 2006-04, Vol.103 (17), p.6688-6693

2006

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Failure of CDKN2A/B (INK4A/B-ARF)-mediated tumor suppression and resistance to targeted therapy in acute lymphoblastic leukemia induced by BCR-ABL

Genes & development, 2008-06, Vol.22 (11), p.1411-1415

2008

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Chemotherapeutic agents circumvent emergence of dasatinib-resistant BCR-ABL kinase mutations in a precise mouse model of Philadelphia chromosome–positive acute lymphoblastic leukemia

Blood, 2011-03, Vol.117 (13), p.3585-3595

2011

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Sumoylation Induced by the Arf Tumor Suppressor: A p53-Independent Function

Proceedings of the National Academy of Sciences - PNAS, 2005-05, Vol.102 (21), p.7689-7694

2005

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N-terminal polyubiquitination and degradation of the Arf tumor suppressor

Genes & development, 2004-08, Vol.18 (15), p.1862-1874

2004

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A New Cell-Cycle Target in Cancer — Inhibiting Cyclin D–Dependent Kinases 4 and 6

The New England journal of medicine, 2016-11, Vol.375 (20), p.1920-1923

Sherr, Charles J

2016

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Senescence-Induced Vascular Remodeling Creates Therapeutic Vulnerabilities in Pancreas Cancer

Cell, 2020-04, Vol.181 (2), p.424-441.e21

2020

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Arf-induced turnover of the nucleolar nucleophosmin-associated SUMO-2/3 protease Senp3

Cell cycle (Georgetown, Tex.), 2008-11, Vol.7 (21), p.3378-3387

2008

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Living with or without cyclins and cyclin-dependent kinases

Genes & development, 2004-11, Vol.18 (22), p.2699-2711

2004

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The RB and p53 pathways in cancer

Cancer Cell, 2002-08, Vol.2 (2), p.103-112

2002

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Myeloid Leukemia-Associated Nucleophosmin Mutants Perturb p53-Dependent and Independent Activities of the Arf Tumor Suppressor Protein

Cell cycle (Georgetown, Tex.), 2005-11, Vol.4 (11), p.1593-1598

2005

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Atoh1 inhibits neuronal differentiation and collaborates with Gli1 to generate medulloblastoma-initiating cells

Cancer research (Chicago, Ill.), 2010-07, Vol.70 (13), p.5618-5627

2010

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Janus kinase inhibition by ruxolitinib extends dasatinib- and dexamethasone-induced remissions in a mouse model of Ph+ ALL

Blood, 2015-02, Vol.125 (9), p.1444-1451

2015

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Developmental strategies for evasion of Arf tumor suppression

Cell cycle (Georgetown, Tex.), 2010-01, Vol.9 (1), p.14-15

2010

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Induction of ARF Tumor Suppressor Gene Expression and Cell Cycle Arrest by Transcription Factor DMP1

Proceedings of the National Academy of Sciences - PNAS, 1999-03, Vol.96 (7), p.3993-3998

1999

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Nucleolar Arf Tumor Suppressor Inhibits Ribosomal RNA Processing

Molecular cell, 2003-02, Vol.11 (2), p.415-424

2003

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The tumor suppressors Ink4c and p53 collaborate independently with Patched to suppress medulloblastoma formation

Genes & development, 2005-11, Vol.19 (22), p.2656-2667

2005

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Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization

Genes & development, 1998-08, Vol.12 (15), p.2424-2433

1998

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Functional and Physical Interactions of the ARF Tumor Suppressor with p53 and Mdm2

Proceedings of the National Academy of Sciences - PNAS, 1998-07, Vol.95 (14), p.8292-8297

1998

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Two Tumor Suppressors, p27Kip1 and Patched-1, Collaborate to Prevent Medulloblastoma

Molecular cancer research, 2009-01, Vol.7 (1), p.33-40

2009

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Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest

Cell, 1995-12, Vol.83 (6), p.993-1000

1995

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Targeting CDK4 and CDK6: From Discovery to Therapy

NK cell-mediated cytotoxicity contributes to tumor control by a cytostatic drug combination

CDK9-mediated transcription elongation is required for MYC addiction in hepatocellular carcinoma

Cancer Cell Cycles

Arf Gene Loss Enhances Oncogenicity and Limits Imatinib Response in Mouse Models of Bcr-Abl-Induced Acute Lymphoblastic Leukemia

Failure of CDKN2A/B (INK4A/B-ARF)-mediated tumor suppression and resistance to targeted therapy in acute lymphoblastic leukemia induced by BCR-ABL

Chemotherapeutic agents circumvent emergence of dasatinib-resistant BCR-ABL kinase mutations in a precise mouse model of Philadelphia chromosome–positive acute lymphoblastic leukemia

Sumoylation Induced by the Arf Tumor Suppressor: A p53-Independent Function

N-terminal polyubiquitination and degradation of the Arf tumor suppressor

A New Cell-Cycle Target in Cancer — Inhibiting Cyclin D–Dependent Kinases 4 and 6

Senescence-Induced Vascular Remodeling Creates Therapeutic Vulnerabilities in Pancreas Cancer

Arf-induced turnover of the nucleolar nucleophosmin-associated SUMO-2/3 protease Senp3

Living with or without cyclins and cyclin-dependent kinases

The RB and p53 pathways in cancer

Myeloid Leukemia-Associated Nucleophosmin Mutants Perturb p53-Dependent and Independent Activities of the Arf Tumor Suppressor Protein

Atoh1 inhibits neuronal differentiation and collaborates with Gli1 to generate medulloblastoma-initiating cells

Janus kinase inhibition by ruxolitinib extends dasatinib- and dexamethasone-induced remissions in a mouse model of Ph+ ALL

Developmental strategies for evasion of Arf tumor suppression

Induction of ARF Tumor Suppressor Gene Expression and Cell Cycle Arrest by Transcription Factor DMP1

Nucleolar Arf Tumor Suppressor Inhibits Ribosomal RNA Processing

The tumor suppressors Ink4c and p53 collaborate independently with Patched to suppress medulloblastoma formation

Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization

Functional and Physical Interactions of the ARF Tumor Suppressor with p53 and Mdm2

Two Tumor Suppressors, p27Kip1 and Patched-1, Collaborate to Prevent Medulloblastoma

Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest

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