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(−)-Rhazinilam and the diphenylpyridazinone NSC 613241: Two compounds inducing the formation of morphologically similar tubulin spirals but binding apparently to two distinct sites on tubulin

Archives of biochemistry and biophysics, 2016-08, Vol.604, p.63-73

2016

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12,13-Aziridinyl Epothilones. Stereoselective Synthesis of Trisubstituted Olefinic Bonds from Methyl Ketones and Heteroaromatic Phosphonates and Design, Synthesis, and Biological Evaluation of Potent Antitumor Agents

Journal of the American Chemical Society, 2017-05, Vol.139 (21), p.7318-7334

2017

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Total Synthesis of Potent Antitumor Macrolide (-)-Zampanolide: An Oxidative Intramolecular Cyclization-Based Strategy

European journal of organic chemistry, 2012-08, Vol.2012 (22), p.4130-4139

2012

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Synthesis and evaluation of diaryl sulfides and diaryl selenide compounds for antitubulin and cytotoxic activity

Bioorganic & medicinal chemistry letters, 2013-08, Vol.23 (16), p.4669-4673

2013

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Discovery of Biarylaminoquinazolines as Novel Tubulin Polymerization Inhibitors

Journal of medicinal chemistry, 2014-06, Vol.57 (11), p.4598-4605

2014

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Enantioselective Synthesis of (+)-Chamaecypanone C: A Novel Microtubule Inhibitor

Angewandte Chemie (International ed.), 2009-01, Vol.48 (8), p.1494-1497

2009

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Deciphering the key heterocyclic scaffolds in targeting microtubules, kinases and carbonic anhydrases for cancer drug development

Pharmacology & therapeutics (Oxford), 2021-09, Vol.225, p.107860, Article 107860

2021

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Actin is the primary cellular receptor of bistramide A

Nature chemical biology, 2005-12, Vol.1 (7), p.383-388

2005

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(−)-RHAZINILAM AND THE DIPHENYLPYRIDAZINONE NSC 613241: TWO COMPOUNDS INDUCING THE FORMATION OF MORPHOLOGICALLY SIMILAR TUBULIN SPIRALS BUT BINDING APPARENTLY TO TWO DISTINCT SITES ON TUBULIN1,2

Archives of biochemistry and biophysics, 2016-06, Vol.604, p.63-73

2016

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Intracellular Activation and Deactivation of Tasidotin, an Analog of Dolastatin 15: Correlation with Cytotoxicity

Molecular pharmacology, 2009-01, Vol.75 (1), p.218-226

2009

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Novel Microtubule-Interacting Phenoxy Pyridine and Phenyl Sulfanyl Pyridine Analogues for Cancer Therapy

Journal of medicinal chemistry, 2008-10, Vol.51 (19), p.5953-5957

2008

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Corrigendum to “The interaction of spongistatin 1 with tubulin” [Arch. Biochem. Biophys. 727 (2022) 109296 (7 pages)]

Archives of biochemistry and biophysics, 2022-11, Vol.730, p.109412-109412, Article 109412

2022

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Pyrrolo[2′,3′:3,4]cyclohepta[1,2‑d][1,2]oxazoles, a New Class of Antimitotic Agents Active against Multiple Malignant Cell Types

Journal of medicinal chemistry, 2020-10, Vol.63 (20), p.12023-12042

2020

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Drug-Linker Constructs Bearing Unique Dual-Mechanism Tubulin Binding Payloads Tethered through Cleavable and Non-Cleavable Linkers

Tetrahedron, 2024-11, p.134350, Article 134350

2024

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The interaction of spongistatin 1 with tubulin

Archives of biochemistry and biophysics, 2022-09, Vol.727, p.109296-109296, Article 109296

2022

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Design, synthesis and biological evaluation of 2-phenyl indole analogues of OXi8006 as colchicine site inhibitors of tubulin polymerization and vascular disrupting agents

Bioorganic & medicinal chemistry, 2024-11, p.117981, Article 117981

2024

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Development of [1,2]oxazoloisoindoles tubulin polymerization inhibitors: Further chemical modifications and potential therapeutic effects against lymphomas

European journal of medicinal chemistry, 2022-12, Vol.243, p.114744-114744, Article 114744

2022

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Novel pyrazolo[4,3-d]pyrimidine microtubule targeting agents (MTAs): Synthesis, structure–activity relationship, in vitro and in vivo evaluation as antitumor agents

Bioorganic & medicinal chemistry letters, 2021-06, Vol.41, p.127923-127923, Article 127923

2021

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(â)-Doliculide, a New Macrocyclic Depsipeptide Enhancer of Actin Assembly

The Journal of biological chemistry, 2002-08, Vol.277 (35), p.32165-32171

2002

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Abstract 6244: Design, synthesis, and structure-activity relationships of substituted pyrido[3,2- d ]pyrimidines as microtubule targeting agents and anti-cancer agents

Cancer research (Chicago, Ill.), 2023-04, Vol.83 (7_Supplement), p.6244-6244

2023

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Induction of Ferroptosis in Glioblastoma and Ovarian Cancers by a New Pyrrole Tubulin Assembly Inhibitor

Journal of medicinal chemistry, 2022-12, Vol.65 (23), p.15805-15818

2022

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Novel pyrazolo4,3-dpyrimidine microtubule targeting agents (MTAs): Synthesis, structure-activity relationship, in vitro and in vivo evaluation as antitumor agents

Bioorganic & medicinal chemistry letters, 2021-06, Vol.41, p.127923

2021

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Synthesis and biological evaluation of indole-2-carbohydrazides and thiazolidinyl-indole-2-carboxamides as potent tubulin polymerization inhibitors

Computational biology and chemistry, 2019-06, Vol.80, p.512-523

2019

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A new anti-tubulin agent containing the benzo[ b]thiophene ring system

Bioorganic & medicinal chemistry letters, 1999-04, Vol.9 (8), p.1081-1086

1999

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(−)-Rhazinilam and the diphenylpyridazinone NSC 613241: Two compounds inducing the formation of morphologically similar tubulin spirals but binding apparently to two distinct sites on tubulin

12,13-Aziridinyl Epothilones. Stereoselective Synthesis of Trisubstituted Olefinic Bonds from Methyl Ketones and Heteroaromatic Phosphonates and Design, Synthesis, and Biological Evaluation of Potent Antitumor Agents

Total Synthesis of Potent Antitumor Macrolide (-)-Zampanolide: An Oxidative Intramolecular Cyclization-Based Strategy

Toward Highly Potent Cancer Agents by Modulating the C‑2 Group of the Arylthioindole Class of Tubulin Polymerization Inhibitors

Synthesis and evaluation of diaryl sulfides and diaryl selenide compounds for antitubulin and cytotoxic activity

Discovery of Biarylaminoquinazolines as Novel Tubulin Polymerization Inhibitors

Enantioselective Synthesis of (+)-Chamaecypanone C: A Novel Microtubule Inhibitor

Deciphering the key heterocyclic scaffolds in targeting microtubules, kinases and carbonic anhydrases for cancer drug development

Actin is the primary cellular receptor of bistramide A

(−)-RHAZINILAM AND THE DIPHENYLPYRIDAZINONE NSC 613241: TWO COMPOUNDS INDUCING THE FORMATION OF MORPHOLOGICALLY SIMILAR TUBULIN SPIRALS BUT BINDING APPARENTLY TO TWO DISTINCT SITES ON TUBULIN1,2

Intracellular Activation and Deactivation of Tasidotin, an Analog of Dolastatin 15: Correlation with Cytotoxicity

Novel Microtubule-Interacting Phenoxy Pyridine and Phenyl Sulfanyl Pyridine Analogues for Cancer Therapy

Corrigendum to “The interaction of spongistatin 1 with tubulin” [Arch. Biochem. Biophys. 727 (2022) 109296 (7 pages)]

Pyrrolo[2′,3′:3,4]cyclohepta[1,2‑d][1,2]oxazoles, a New Class of Antimitotic Agents Active against Multiple Malignant Cell Types

Drug-Linker Constructs Bearing Unique Dual-Mechanism Tubulin Binding Payloads Tethered through Cleavable and Non-Cleavable Linkers

The interaction of spongistatin 1 with tubulin

Design, synthesis and biological evaluation of 2-phenyl indole analogues of OXi8006 as colchicine site inhibitors of tubulin polymerization and vascular disrupting agents

Development of [1,2]oxazoloisoindoles tubulin polymerization inhibitors: Further chemical modifications and potential therapeutic effects against lymphomas

Novel pyrazolo[4,3-d]pyrimidine microtubule targeting agents (MTAs): Synthesis, structure–activity relationship, in vitro and in vivo evaluation as antitumor agents

(â)-Doliculide, a New Macrocyclic Depsipeptide Enhancer of Actin Assembly

Abstract 6244: Design, synthesis, and structure-activity relationships of substituted pyrido[3,2- d ]pyrimidines as microtubule targeting agents and anti-cancer agents

Induction of Ferroptosis in Glioblastoma and Ovarian Cancers by a New Pyrrole Tubulin Assembly Inhibitor

Novel pyrazolo4,3-dpyrimidine microtubule targeting agents (MTAs): Synthesis, structure-activity relationship, in vitro and in vivo evaluation as antitumor agents

Synthesis and biological evaluation of indole-2-carbohydrazides and thiazolidinyl-indole-2-carboxamides as potent tubulin polymerization inhibitors

A new anti-tubulin agent containing the benzo[ b]thiophene ring system

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