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Procedures for large-scale metabolic profiling of serum and plasma using gas chromatography and liquid chromatography coupled to mass spectrometry

Nature protocols, 2011-07, Vol.6 (7), p.1060-1083

2011

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A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria

Science translational medicine, 2015-07, Vol.7 (296), p.296ra111

2015

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Use of liquid chromatography/time-of-flight mass spectrometry and multivariate statistical analysis shows promise for the detection of drug metabolites in biological fluids

Rapid communications in mass spectrometry, 2003-01, Vol.17 (23), p.2632-2638

2003

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Metabonomics: the use of electrospray mass spectrometry coupled to reversed-phase liquid chromatography shows potential for the screening of rat urine in drug development

Rapid communications in mass spectrometry, 2002-01, Vol.16 (20), p.1991-1996

2002

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A gender-specific discriminator in Sprague–Dawley rat urine: The deployment of a metabolic profiling strategy for biomarker discovery and identification

Analytical biochemistry, 2007-03, Vol.362 (2), p.182-192

2007

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A Functional Analysis of Mouse Models of Cardiac Disease through Metabolic Profiling

The Journal of biological chemistry, 2005-03, Vol.280 (9), p.7530-7539

2005

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Personalized medicine progresses

Nature medicine, 2006-05, Vol.12 (5), p.510-511

2006

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4,4-Dimethyl-4-silapentane-1-ammonium trifluoroacetate (DSA), a promising universal internal standard for NMR-based metabolic profiling studies of biofluids, including blood plasma and serum

Metabolomics, 2008-06, Vol.4 (2), p.122-127

2008

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approach for the development and selection of chromatographic methods for high-throughput metabolomic screening of urine by ultra pressure LC-ESI-ToF-MS

Metabolomics, 2009-06, Vol.5 (2), p.166-182

2009

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Peak Alignment of Urine NMR Spectra Using Fuzzy Warping

Journal of chemical information and modeling, 2006-03, Vol.46 (2), p.863-875

2006

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A human microdose study of the antimalarial drug GSK3191607 in healthy volunteers

British journal of clinical pharmacology, 2018-03, Vol.84 (3), p.482-489

2018

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Correction to The Discovery of Novel Antimalarial Aminoxadiazoles as a Promising Nonendoperoxide Scaffold

Journal of medicinal chemistry, 2017-12, Vol.60 (23), p.9911-9911

2017

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Development of a multivariate statistical model to predict peroxisome proliferation in the rat, based on urinary 1H-NMR spectral patterns

Biomarkers, 2004-07, Vol.9 (4-5), p.364-385

2004

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The metabolism of the xenobiotic triacylglycerols, rac-1- and sn-2- (3-phenoxybenzoyl)-dipalmitoylglycerol, following intravenous administration to the rat

Biochemical pharmacology, 1998-12, Vol.56 (12), p.1599-1606

1998

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Potential urinary and plasma biomarkers of peroxisome proliferation in the rat: identification of N -methylnicotinamide and N -methyl-4-pyridone-3-carboxamide by 1H nuclear magnetic resonance and high performance liquid chromatography

Biomarkers, 2003-05, Vol.8 (3-4), p.240-271

2003

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Increased hepatic oxidative metabolism distinguishes the action of Peroxisome proliferator-activated receptor delta from Peroxisome proliferator-activated receptor gamma in the ob/ob mouse

Genome medicine, 2009-12, Vol.1 (12), p.115-115

2009

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Increased hepatic oxidative metabolism distinguishes the action of Peroxisome proliferator-activated receptor [delta] from Peroxisome proliferator-activated receptor [gamma] in the ob / ob mouse

Genome medicine, 2009-12, Vol.1, p.115

2009

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Tryptophan-NAD super(+) pathway metabolites as putative biomarkers and predictors of peroxisome proliferation

Archives of toxicology, 2005-04, Vol.79 (4), p.208-223

2005

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Effects of feeding and body weight loss on the super(1)H-NMR-based urine metabolic profiles of male Wistar Han rats: implications for biomarker discovery

Biomarkers, 2004-03, Vol.9 (2), p.156-179

2004

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Development of a multivariate statistical model to predict peroxisome proliferation in the rat, based on urinary 1 H-NMR spectral patterns

Biomarkers, 2004-01, Vol.9 (4-5), p.364-385

2004

Volltextzugriff (PDF)

Effects of feeding and body weight loss on the 1 H-NMR-based urine metabolic profiles of male Wistar Han Rats: Implications for biomarker discovery

Biomarkers, 2004-01, Vol.9 (2), p.156-179

2004

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The identification of a marker of phospholipidosis using biofluid 1H NMR spectroscopy

Toxicology (Amsterdam), 2000-07, Vol.148 (1), p.76-77

2000

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Potential urinary and plasma biomarkers of peroxisome proliferation in the rat: identification of N -methylnicotinamide and N -methyl-4-pyridone-3-carboxamide by 1 H nuclear magnetic resonance and high performance liquid chromatography

Biomarkers, 2003-01, Vol.8 (3-4), p.240-271

2003

Volltextzugriff (PDF)

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Procedures for large-scale metabolic profiling of serum and plasma using gas chromatography and liquid chromatography coupled to mass spectrometry

A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria

Molecular phenotyping of a UK population: defining the human serum metabolome

Use of liquid chromatography/time-of-flight mass spectrometry and multivariate statistical analysis shows promise for the detection of drug metabolites in biological fluids

Metabonomics: the use of electrospray mass spectrometry coupled to reversed-phase liquid chromatography shows potential for the screening of rat urine in drug development

A gender-specific discriminator in Sprague–Dawley rat urine: The deployment of a metabolic profiling strategy for biomarker discovery and identification

A Functional Analysis of Mouse Models of Cardiac Disease through Metabolic Profiling

Personalized medicine progresses

4,4-Dimethyl-4-silapentane-1-ammonium trifluoroacetate (DSA), a promising universal internal standard for NMR-based metabolic profiling studies of biofluids, including blood plasma and serum

approach for the development and selection of chromatographic methods for high-throughput metabolomic screening of urine by ultra pressure LC-ESI-ToF-MS

Peak Alignment of Urine NMR Spectra Using Fuzzy Warping

A human microdose study of the antimalarial drug GSK3191607 in healthy volunteers

Summary recommendations for standardization and reporting of metabolic analyses

Correction to The Discovery of Novel Antimalarial Aminoxadiazoles as a Promising Nonendoperoxide Scaffold

Development of a multivariate statistical model to predict peroxisome proliferation in the rat, based on urinary 1H-NMR spectral patterns

The metabolism of the xenobiotic triacylglycerols, rac-1- and sn-2- (3-phenoxybenzoyl)-dipalmitoylglycerol, following intravenous administration to the rat

Potential urinary and plasma biomarkers of peroxisome proliferation in the rat: identification of N -methylnicotinamide and N -methyl-4-pyridone-3-carboxamide by 1H nuclear magnetic resonance and high performance liquid chromatography

Increased hepatic oxidative metabolism distinguishes the action of Peroxisome proliferator-activated receptor delta from Peroxisome proliferator-activated receptor gamma in the ob/ob mouse

Increased hepatic oxidative metabolism distinguishes the action of Peroxisome proliferator-activated receptor [delta] from Peroxisome proliferator-activated receptor [gamma] in the ob / ob mouse

Tryptophan-NAD super(+) pathway metabolites as putative biomarkers and predictors of peroxisome proliferation

Effects of feeding and body weight loss on the super(1)H-NMR-based urine metabolic profiles of male Wistar Han rats: implications for biomarker discovery

Development of a multivariate statistical model to predict peroxisome proliferation in the rat, based on urinary 1 H-NMR spectral patterns

Effects of feeding and body weight loss on the 1 H-NMR-based urine metabolic profiles of male Wistar Han Rats: Implications for biomarker discovery

The identification of a marker of phospholipidosis using biofluid 1H NMR spectroscopy

Potential urinary and plasma biomarkers of peroxisome proliferation in the rat: identification of N -methylnicotinamide and N -methyl-4-pyridone-3-carboxamide by 1 H nuclear magnetic resonance and high performance liquid chromatography

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