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Design, Synthesis, and Evaluation of Conformationally Restricted Acetanilides as Potent and Selective β3 Adrenergic Receptor Agonists for the Treatment of Overactive Bladder

Journal of medicinal chemistry, 2014-02, Vol.57 (4), p.1437-1453

2014

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A Computational Physics-based Approach to Predict Unbound Brain-to-Plasma Partition Coefficient, Kp,uu

Journal of chemical information and modeling, 2023-06, Vol.63 (12), p.3786-3798

2023

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The urinary metabolite profile of the dietary carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine is predictive of colon dna adducts after a low-dose exposure in humans

Cancer research (Chicago, Ill.), 2006-11, Vol.66 (21), p.10541-10547

2006

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In Vivo Efficacy of Relebactam (MK-7655) in Combination with Imipenem-Cilastatin in Murine Infection Models

Antimicrobial agents and chemotherapy, 2018-08, Vol.62 (8)

2018

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A Computational Physics-based Approach to Predict Unbound Brain-to-Plasma Partition Coefficient, K p,uu

Journal of chemical information and modeling, 2023-06, Vol.63 (12), p.3786-3798

2023

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Accelerator Mass Spectrometry for Biomedical Research

Methods in Enzymology, 2005, Vol.402, p.423-443

2005

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Inflammation and Atrophy Precede Prostatic Neoplasia in a PhIP-Induced Rat Model

Neoplasia (New York, N.Y.), 2006-09, Vol.8 (9), p.708-715

2006

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Discovery of phenyl acetamides as potent and selective GPR119 agonists

Bioorganic & medicinal chemistry letters, 2017-03, Vol.27 (5), p.1124-1128

2017

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Optimization of Preclinical Metabolism for Somatostatin Receptor Subtype 5‑Selective Antagonists

ACS medicinal chemistry letters, 2018-11, Vol.9 (11), p.1088-1093

2018

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Sample Preparation for Quantitation of Tritium by Accelerator Mass Spectrometry

Analytical chemistry (Washington), 2002-12, Vol.74 (24), p.6285-6290

2002

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Discovery and Optimization of a Novel Triazole Series of GPR142 Agonists for the Treatment of Type 2 Diabetes

ACS medicinal chemistry letters, 2016-12, Vol.7 (12), p.1107-1111

2016

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Design of Potent and Orally Active GPR119 Agonists for the Treatment of Type II Diabetes

ACS medicinal chemistry letters, 2015-08, Vol.6 (8), p.936-941

2015

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DNA and Protein Adduct Formation in the Colon and Blood of Humans after Exposure to a Dietary-relevant Dose of 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine

Cancer epidemiology, biomarkers & prevention, 1999-06, Vol.8 (6), p.507-512

1999

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The identification of [2-14C]2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine metabolites in humans

Carcinogenesis (New York), 1999-04, Vol.20 (4), p.705-713

1999

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Macromolecular adduct formation and metabolism of heterocyclic amines in humans and rodents at low doses

Cancer letters, 1999-09, Vol.143 (2), p.149-155

1999

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Use of Tritium Accelerator Mass Spectrometry for Tree Ring Analysis

Environmental science & technology, 2002-07, Vol.36 (13), p.2848-2852

2002

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Attomole Detection of 3H in Biological Samples Using Accelerator Mass Spectrometry: Application in Low-Dose, Dual-Isotope Tracer Studies in Conjunction with 14C Accelerator Mass Spectrometry

Chemical research in toxicology, 1998-10, Vol.11 (10), p.1217-1222

1998

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Comparison of DNA‐adduct and tissue‐available dose levels of MeIQx in human and rodent colon following administration of a very low dose

International journal of cancer, 1999-02, Vol.80 (4), p.539-545

1999

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Inflammation and Atrophy Precede Prostatic Neoplasia in a PhIP-Induced Rat Model1

Neoplasia (New York, N.Y.), 2006-09, Vol.8 (9), p.708-715

2006

Volltextzugriff (PDF)

Covalent binding of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline to albumin and hemoglobin at environmentally relevant doses. Comparison of human subjects and F344 rats

Drug metabolism and disposition, 1998-08, Vol.26 (8), p.825

1998

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Detectable levels of serum aflatoxin B1-albumin adducts in the United Kingdom population: implications for aflatoxin-B1 exposure in the United Kingdom

Cancer epidemiology, biomarkers & prevention, 1998-05, Vol.7 (5), p.441

1998

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In vivo human metabolism of [2- 14C]2-amino-1-methyl-6-phenylimidazo[4,5- b]pyridine (PhIP)

Cancer letters, 1999-09, Vol.143 (2), p.135-138

1999

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Attomole Detection of 3 H in Biological Samples Using Accelerator Mass Spectrometry: Application in Low-Dose, Dual-Isotope Tracer Studies in Conjunction with 14 C Accelerator Mass Spectrometry

Chemical research in toxicology, 1998-10, Vol.11 (10), p.1217-1222

1998

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Biomonitoring of possible human exposure to environmental genotoxic chemicals: Lessons from a study following the wreck of the oil tankerBraer

Environmental and molecular mutagenesis, 1997, Vol.30 (2), p.97-111

1997

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Design, Synthesis, and Evaluation of Conformationally Restricted Acetanilides as Potent and Selective β3 Adrenergic Receptor Agonists for the Treatment of Overactive Bladder

A Computational Physics-based Approach to Predict Unbound Brain-to-Plasma Partition Coefficient, Kp,uu

The urinary metabolite profile of the dietary carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine is predictive of colon dna adducts after a low-dose exposure in humans

In Vivo Efficacy of Relebactam (MK-7655) in Combination with Imipenem-Cilastatin in Murine Infection Models

A Computational Physics-based Approach to Predict Unbound Brain-to-Plasma Partition Coefficient, K p,uu

Accelerator Mass Spectrometry for Biomedical Research

Inflammation and Atrophy Precede Prostatic Neoplasia in a PhIP-Induced Rat Model

Discovery of phenyl acetamides as potent and selective GPR119 agonists

Optimization of Preclinical Metabolism for Somatostatin Receptor Subtype 5‑Selective Antagonists

Sample Preparation for Quantitation of Tritium by Accelerator Mass Spectrometry

Discovery and Optimization of a Novel Triazole Series of GPR142 Agonists for the Treatment of Type 2 Diabetes

Design of Potent and Orally Active GPR119 Agonists for the Treatment of Type II Diabetes

DNA and Protein Adduct Formation in the Colon and Blood of Humans after Exposure to a Dietary-relevant Dose of 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine

The identification of [2-14C]2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine metabolites in humans

Macromolecular adduct formation and metabolism of heterocyclic amines in humans and rodents at low doses

Use of Tritium Accelerator Mass Spectrometry for Tree Ring Analysis

Design, Synthesis, and Evaluation of Conformationally Restricted Acetanilides as Potent and Selective β 3 Adrenergic Receptor Agonists for the Treatment of Overactive Bladder

Attomole Detection of 3H in Biological Samples Using Accelerator Mass Spectrometry: Application in Low-Dose, Dual-Isotope Tracer Studies in Conjunction with 14C Accelerator Mass Spectrometry

Comparison of DNA‐adduct and tissue‐available dose levels of MeIQx in human and rodent colon following administration of a very low dose

Inflammation and Atrophy Precede Prostatic Neoplasia in a PhIP-Induced Rat Model1

Covalent binding of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline to albumin and hemoglobin at environmentally relevant doses. Comparison of human subjects and F344 rats

Detectable levels of serum aflatoxin B1-albumin adducts in the United Kingdom population: implications for aflatoxin-B1 exposure in the United Kingdom

In vivo human metabolism of [2- 14C]2-amino-1-methyl-6-phenylimidazo[4,5- b]pyridine (PhIP)

Attomole Detection of 3 H in Biological Samples Using Accelerator Mass Spectrometry: Application in Low-Dose, Dual-Isotope Tracer Studies in Conjunction with 14 C Accelerator Mass Spectrometry

Biomonitoring of possible human exposure to environmental genotoxic chemicals: Lessons from a study following the wreck of the oil tankerBraer

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