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Transgenic mouse models of tauopathy in drug discovery

CNS & neurological disorders drug targets, 2010-08, Vol.9 (4), p.403-428

2010

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Parkinson's disease alpha-synuclein mutations exhibit defective axonal transport in cultured neurons

Journal of cell science, 2004-03, Vol.117 (Pt 7), p.1017-1024

2004

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Induction of neuronal death by α-synuclein

The European journal of neuroscience, 2000-08, Vol.12 (8), p.3073-3077

2000

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Familial Danish Dementia: A Novel Form of Cerebral Amyloidosis Associated with Deposition of Both Amyloid-Dan and Amyloid-Beta

Journal of neuropathology and experimental neurology, 2002-03, Vol.61 (3), p.254-267

2002

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Tau protein in the glial cytoplasmic inclusions of multiple system atrophy can be distinguished from abnormal tau in Alzheimer's disease

Neuroscience letters, 1997-07, Vol.230 (1), p.49-52

1997

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Oxidative Stress Induces Dephosphorylation of τ in Rat Brain Primary Neuronal Cultures

Journal of neurochemistry, 1997-04, Vol.68 (4), p.1590-1597

1997

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A68 proteins in Alzheimer's disease are composed of several tau isoforms in a phosphorylated state which affects their electrophoretic mobilities

Biochemical journal, 1991-11, Vol.279 (3), p.831-836

1991

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Tau in Alzheimer's disease and Down's syndrome is insoluble and abnormally phosphorylated

Biochemical journal, 1991-04, Vol.275 (1), p.99-104

1991

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PHF-tau from Alzheimer's brain comprises four species on SDS-PAGE which can be mimicked by in vitro phosphorylation of human brain tau by glycogen synthase kinase-3β

FEBS letters, 1994-08, Vol.349 (3), p.359-364

1994

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The phosphorylation state of the microtubule-associated protein tau as affected by glutamate, colchicine and beta-amyloid in primary rat cortical neuronal cultures

Biochemical journal, 1995-08, Vol.309 ( Pt 3) (3), p.941-949

1995

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Pathological lesions of Alzheimer's disease and dementia with Lewy bodies brains exhibit immunoreactivity to an ATPase that is a regulatory subunit of the 26S proteasome

Neuroscience letters, 1996-11, Vol.219 (3), p.167-170

1996

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The ultrastructural distribution of alpha-synuclein-like protein in normal mouse brain

Brain research, 2004-04, Vol.1004 (1), p.61-72

2004

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S.03.02 Tau phosphorylation in Alzheimer's disease

European neuropsychopharmacology, 2003-10, Vol.13, p.S100-S100

Hanger, D.

2003

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Tau in Alzheimer neurofibrillary tangles. N- and C-terminal regions are differentially associated with paired helical filaments and the location of a putative abnormal phosphorylation site

Biochemical journal, 1991-01, Vol.273(Pt 1) (1), p.127-133

1991

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Alzheimer's disease-like phosphorylation of the microtubule-associated protein tau by glycogen synthase kinase-3 in transfected mammalian cells

Current biology, 1994-12, Vol.4 (12), p.1077-1086

1994

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Sites of phosphorylation in tau and factors affecting their regulation

Biochemical Society Symposia, 2001-01, Vol.67 (67), p.73-80

2001

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Expression and phosphorylation of a three-repeat isoform of tau in transfected non-neuronal cells

Biochemical journal, 1992-09, Vol.286 (2), p.399-404

1992

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High temperature nanoindentation of iron: Experimental and computational study

Journal of nuclear materials, 2022-08, Vol.567, p.153815, Article 153815

2022

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Molecular pathology of Alzheimer's disease in sporadic and familial Alzheimer's disease with mutations in the amyloid precursor protein

Biochemical Society transactions, 1992-08, Vol.20 (3), p.642-645

1992

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Fluconazole and testosterone: in vivo and in vitro studies

Antimicrobial Agents and Chemotherapy, 1988-05, Vol.32 (5), p.646-648

1988

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Phosphorylation of tau by glycogen synthase kinase-3 beta in vitro produces species with similar electrophoretic and immunogenic properties to PHF-tau from Alzheimer's disease brain

Biochemical Society transactions, 1995-02, Vol.23 (1), p.45S

1995

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Neurodegenerative changes including altered tau phosphorylation and neurofilament immunoreactivity in mice transgenic for the serine/threonine kinase mos

Neurobiology of aging, 1996-03, Vol.17 (2), p.235-241

1996

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Astrocytes are important mediators of A -induced neurotoxicity and tau phosphorylation in primary culture

Cell death & disease, 2011-06, Vol.2 (6), p.e167

2011

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Behavioral effects of dopamine agonists and antagonists in MPTP-lesioned D 3 receptor knockout mice

Pharmacology, biochemistry and behavior, 2003-12, Vol.76 (3), p.551-562

2003

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Behavioral effects of dopamine agonists and antagonists in MPTP-lesioned D sub(3) receptor knockout mice

Pharmacology, biochemistry and behavior, 2003-12, Vol.76 (3-4), p.551-562

2003

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Transgenic mouse models of tauopathy in drug discovery

Parkinson's disease alpha-synuclein mutations exhibit defective axonal transport in cultured neurons

Induction of neuronal death by α-synuclein

Familial Danish Dementia: A Novel Form of Cerebral Amyloidosis Associated with Deposition of Both Amyloid-Dan and Amyloid-Beta

Tau protein in the glial cytoplasmic inclusions of multiple system atrophy can be distinguished from abnormal tau in Alzheimer's disease

Oxidative Stress Induces Dephosphorylation of τ in Rat Brain Primary Neuronal Cultures

A68 proteins in Alzheimer's disease are composed of several tau isoforms in a phosphorylated state which affects their electrophoretic mobilities

Tau in Alzheimer's disease and Down's syndrome is insoluble and abnormally phosphorylated

PHF-tau from Alzheimer's brain comprises four species on SDS-PAGE which can be mimicked by in vitro phosphorylation of human brain tau by glycogen synthase kinase-3β

The phosphorylation state of the microtubule-associated protein tau as affected by glutamate, colchicine and beta-amyloid in primary rat cortical neuronal cultures

Pathological lesions of Alzheimer's disease and dementia with Lewy bodies brains exhibit immunoreactivity to an ATPase that is a regulatory subunit of the 26S proteasome

The ultrastructural distribution of alpha-synuclein-like protein in normal mouse brain

S.03.02 Tau phosphorylation in Alzheimer's disease

Tau in Alzheimer neurofibrillary tangles. N- and C-terminal regions are differentially associated with paired helical filaments and the location of a putative abnormal phosphorylation site

Alzheimer's disease-like phosphorylation of the microtubule-associated protein tau by glycogen synthase kinase-3 in transfected mammalian cells

Sites of phosphorylation in tau and factors affecting their regulation

Expression and phosphorylation of a three-repeat isoform of tau in transfected non-neuronal cells

High temperature nanoindentation of iron: Experimental and computational study

Molecular pathology of Alzheimer's disease in sporadic and familial Alzheimer's disease with mutations in the amyloid precursor protein

Fluconazole and testosterone: in vivo and in vitro studies

Phosphorylation of tau by glycogen synthase kinase-3 beta in vitro produces species with similar electrophoretic and immunogenic properties to PHF-tau from Alzheimer's disease brain

Neurodegenerative changes including altered tau phosphorylation and neurofilament immunoreactivity in mice transgenic for the serine/threonine kinase mos

Astrocytes are important mediators of A -induced neurotoxicity and tau phosphorylation in primary culture

Behavioral effects of dopamine agonists and antagonists in MPTP-lesioned D 3 receptor knockout mice

Behavioral effects of dopamine agonists and antagonists in MPTP-lesioned D sub(3) receptor knockout mice

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