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Liquid–liquid phase separation of the microtubule-binding repeats of the Alzheimer-related protein Tau

Nature communications, 2017-08, Vol.8 (1), p.275-13, Article 275

2017

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Lysine/RNA-interactions drive and regulate biomolecular condensation

Nature communications, 2019-07, Vol.10 (1), p.2909-15, Article 2909

2019

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Residue-specific identification of phase separation hot spots of Alzheimer's-related protein tau

Chemical science (Cambridge), 2019-07, Vol.1 (26), p.653-657

2019

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Novel diffusion barrier for axonal retention of Tau in neurons and its failure in neurodegeneration

The EMBO journal, 2011-11, Vol.30 (23), p.4825-4837

2011

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Multivalent cross-linking of actin filaments and microtubules through the microtubule-associated protein Tau

Nature communications, 2017-12, Vol.8 (1), p.1981-12, Article 1981

2017

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Lipid membrane templated misfolding and self-assembly of intrinsically disordered tau protein

Scientific reports, 2020-08, Vol.10 (1), p.13324-13324, Article 13324

2020

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Tau-induced defects in synaptic plasticity, learning, and memory are reversible in transgenic mice after switching off the toxic Tau mutant

The Journal of neuroscience, 2011-02, Vol.31 (7), p.2511-2525

2011

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Oligomer Formation of Tau Protein Hyperphosphorylated in Cells

The Journal of biological chemistry, 2014-12, Vol.289 (49), p.34389-34407

2014

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A mechanistic model of tau amyloid aggregation based on direct observation of oligomers

Nature communications, 2015-04, Vol.6 (1), p.7025-7025, Article 7025

2015

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Solid-state NMR investigation of the involvement of the P2 region in tau amyloid fibrils

Scientific reports, 2020-12, Vol.10 (1), p.21210, Article 21210

2020

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Inhibition of tau aggregation in a novel Caenorhabditis elegans model of tauopathy mitigates proteotoxicity

Human molecular genetics, 2012-08, Vol.21 (16), p.3587-3603

2012

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Proline-directed Pseudo-phosphorylation at AT8 and PHF1 Epitopes Induces a Compaction of the Paperclip Folding of Tau and Generates a Pathological (MC-1) Conformation

The Journal of biological chemistry, 2008-11, Vol.283 (46), p.32066-32076

2008

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Acetylation mimic of lysine 280 exacerbates human Tau neurotoxicity in vivo

Scientific reports, 2016-03, Vol.6 (1), p.22685, Article 22685

2016

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fuzzy coat of pathological human Tau fibrils is a two-layered polyelectrolyte brush

Proceedings of the National Academy of Sciences - PNAS, 2013-01, Vol.110 (4), p.E313-E321

2013

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Structural Impact of Tau Phosphorylation at Threonine 231

Structure (London), 2015-08, Vol.23 (8), p.1448-1458

2015

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Structural polymorphism of 441-residue tau at single residue resolution

PLoS biology, 2009-02, Vol.7 (2), p.e34-e1000034

2009

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FRET-based Tau seeding assay does not represent prion-like templated assembly of Tau filaments

Molecular neurodegeneration, 2020-07, Vol.15 (1), p.1-39, Article 39

2020

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Stages and Conformations of the Tau Repeat Domain during Aggregation and Its Effect on Neuronal Toxicity

The Journal of biological chemistry, 2014-07, Vol.289 (29), p.20318-20332

2014

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Reversal of Tau-Dependent Cognitive Decay by Blocking Adenosine A1 Receptors: Comparison of Transgenic Mouse Models with Different Levels of Tauopathy

International journal of molecular sciences, 2023-05, Vol.24 (11), p.9260

2023

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Anthraquinones Inhibit Tau Aggregation and Dissolve Alzheimer's Paired Helical Filaments in Vitro and in Cells

The Journal of biological chemistry, 2005-02, Vol.280 (5), p.3628-3635

2005

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Structure and pro-toxic mechanism of the human Hsp90/PPIase/Tau complex

Nature communications, 2018-10, Vol.9 (1), p.4532-13, Article 4532

2018

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Tau mutant A152T, a risk factor for FTD/PSP, induces neuronal dysfunction and reduced lifespan independently of aggregation in a C. elegans Tauopathy model

Molecular neurodegeneration, 2016-04, Vol.11 (1), Article 33

2016

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Glutamatergic nervous system degeneration in a C. elegans TauA152T tauopathy model involves pathways of excitotoxicity and Ca2+ dysregulation

Neurobiology of disease, 2018-09, Vol.117, p.189-202

2018

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Initiation and modulation of Tau protein phase separation by the drug suramin

Scientific reports, 2023-03, Vol.13 (1), p.3963-3963, Article 3963

2023

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Pro-aggregant Tau impairs mossy fiber plasticity due to structural changes and Ca(++) dysregulation

Acta neuropathologica communications, 2015-04, Vol.3 (1), p.23-23, Article 23

2015

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Liquid–liquid phase separation of the microtubule-binding repeats of the Alzheimer-related protein Tau

Lysine/RNA-interactions drive and regulate biomolecular condensation

Residue-specific identification of phase separation hot spots of Alzheimer's-related protein tau

Novel diffusion barrier for axonal retention of Tau in neurons and its failure in neurodegeneration

Multivalent cross-linking of actin filaments and microtubules through the microtubule-associated protein Tau

Lipid membrane templated misfolding and self-assembly of intrinsically disordered tau protein

Tau-induced defects in synaptic plasticity, learning, and memory are reversible in transgenic mice after switching off the toxic Tau mutant

Oligomer Formation of Tau Protein Hyperphosphorylated in Cells

A mechanistic model of tau amyloid aggregation based on direct observation of oligomers

Solid-state NMR investigation of the involvement of the P2 region in tau amyloid fibrils

Inhibition of tau aggregation in a novel Caenorhabditis elegans model of tauopathy mitigates proteotoxicity

Proline-directed Pseudo-phosphorylation at AT8 and PHF1 Epitopes Induces a Compaction of the Paperclip Folding of Tau and Generates a Pathological (MC-1) Conformation

Acetylation mimic of lysine 280 exacerbates human Tau neurotoxicity in vivo

fuzzy coat of pathological human Tau fibrils is a two-layered polyelectrolyte brush

Structural Impact of Tau Phosphorylation at Threonine 231

Structural polymorphism of 441-residue tau at single residue resolution

FRET-based Tau seeding assay does not represent prion-like templated assembly of Tau filaments

Stages and Conformations of the Tau Repeat Domain during Aggregation and Its Effect on Neuronal Toxicity

Reversal of Tau-Dependent Cognitive Decay by Blocking Adenosine A1 Receptors: Comparison of Transgenic Mouse Models with Different Levels of Tauopathy

Anthraquinones Inhibit Tau Aggregation and Dissolve Alzheimer's Paired Helical Filaments in Vitro and in Cells

Structure and pro-toxic mechanism of the human Hsp90/PPIase/Tau complex

Tau mutant A152T, a risk factor for FTD/PSP, induces neuronal dysfunction and reduced lifespan independently of aggregation in a C. elegans Tauopathy model

Glutamatergic nervous system degeneration in a C. elegans TauA152T tauopathy model involves pathways of excitotoxicity and Ca2+ dysregulation

Initiation and modulation of Tau protein phase separation by the drug suramin

Pro-aggregant Tau impairs mossy fiber plasticity due to structural changes and Ca(++) dysregulation

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