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MEK/ERK‐mediated oncogenic signals promote secretion of extracellular vesicles by controlling lysosome function

Cancer science, 2022-04, Vol.113 (4), p.1264-1276

2022

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Asteltoxin inhibits extracellular vesicle production through AMPK/mTOR-mediated activation of lysosome function

Scientific reports, 2022-04, Vol.12 (1), p.6674-6674, Article 6674

2022

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The way forward for neuroethics in Japan: A review of five topics surrounding present challenges

Neuroscience research, 2022-10, Vol.183, p.7-16

2022

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Val143 of human ribonuclease H2 is not critical for, but plays a role in determining catalytic activity and substrate specificity

PloS one, 2020-02, Vol.15 (2), p.e0228774-e0228774

2020

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Development of Wearable Sheet-Type Shear Force Sensor and Measurement System that is Insusceptible to Temperature and Pressure

Sensors (Basel, Switzerland), 2017-07, Vol.17 (8), p.1752

2017

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Insertion loop‐mediated folding propagation governs efficient maturation of hyperthermophilic Tk‐subtilisin at high temperatures

FEBS letters, 2021-02, Vol.595 (4), p.452-461

2021

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Aicardi-Goutières syndrome gene Rnaseh2c is a metastasis susceptibility gene in breast cancer

PLoS genetics, 2019-05, Vol.15 (5), p.e1008020-e1008020

2019

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Crystal structures of the cell‐division protein FtsZ from Klebsiella pneumoniae and Escherichia coli

Acta crystallographica. Section F, Structural biology communications, 2020-02, Vol.76 (2), p.86-93

2020

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Requirement of Ca2+ Ions for the Hyperthermostability of Tk-Subtilisin from Thermococcus kodakarensis

Biochemistry (Easton), 2012-07, Vol.51 (26), p.5369-5378

2012

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Accelerated maturation of Tk‐subtilisin by a Leu→Promutation at the C‐terminus of the propeptide, which reduces the binding of the propeptide to Tk‐subtilisin

The FEBS journal, 2013-02, Vol.280 (4), p.994-1006

2013

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Is Conceptual Engineering from Japan Feasible?: A Review of Conceptual Engineering Manifesto edited by Kasuhisa Todayama and Kaori Karasawa

Kagaku tetsugaku, 2021-03, Vol.53 (2), p.259-273

Uehara, Ryo

2021

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Increase in activation rate of Pro‐Tk‐subtilisin by a single nonpolar‐to‐polar amino acid substitution at the hydrophobic core of the propeptide domain

Protein science, 2013-12, Vol.22 (12), p.1711-1721

2013

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Requirement of insertion sequence IS1 for thermal adaptation of Pro-Tk-subtilisin from hyperthermophilic archaeon

Extremophiles : life under extreme conditions, 2012-11, Vol.16 (6), p.841-851

2012

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超好熱性サチライシンをモデルにみるタンパク質フォールディングの高温環境適応戦略: Tk-subtilisinと3つの挿入配列

Kagaku To Seibutsu, 2021-06, Vol.59 (6), p.272-274, Article 590602

2021

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Two RNase H2 Mutants with Differential rNMP Processing Activity Reveal a Threshold of Ribonucleotide Tolerance for Embryonic Development

Cell reports (Cambridge), 2018-10, Vol.25 (5), p.1135-1145.e5

2018

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Unlike the Escherichia coli counterpart, archaeal RNase HII cannot process ribose monophosphate abasic sites and oxidized ribonucleotides embedded in DNA

The Journal of biological chemistry, 2019-08, Vol.294 (35), p.13061-13072

2019

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Crystal structure of a GH1 β‐glucosidase from Hamamotoa singularis

Protein science, 2020-09, Vol.29 (9), p.2000-2008

2020

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Cognitive Enhancement and Destruction of the Self

Journal of the Japan Association for Philosophy of Science, 2008, Vol.35 (2), p.77-86

UEHARA, Ryo

2008

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Formation of the High-Affinity Calcium Binding Site in Pro-subtilisin E with the Insertion Sequence IS1 of Pro-Tk-subtilisin

Biochemistry (Easton), 2013-12, Vol.52 (50), p.9080-9088

2013

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Requirement of Ca(2+) ions for the hyperthermostability of Tk-subtilisin from Thermococcus kodakarensis

Biochemistry (Easton), 2012-07, Vol.51 (26), p.5369-5378

2012

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超好熱性サチライシンをモデルにみるタンパク質フォールディングの高温環境適応戦略: Tk-subtilisinと3つの挿入配列

化学と生物, 2021/06/01, Vol.59(6), pp.272-274

2021

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Accelerated maturation of Tk‐subtilisin by a L eu→ P romutation at the C ‐terminus of the propeptide, which reduces the binding of the propeptide to T k‐subtilisin

The FEBS journal, 2013-02, Vol.280 (4), p.994-1006

2013

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Requirement of Ca 2+ Ions for the Hyperthermostability of Tk-Subtilisin from Thermococcus kodakarensis

Biochemistry (Easton), 2012-07, Vol.51 (26), p.5369-5378

2012

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Construction of a supermicro sense of force feedback and vision for micro-objects: development of a haptic device

Artificial life and robotics, 2009-11, Vol.14 (2), p.104-109

2009

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Placing Knowledge in the World

Journal of the Japan Association for Philosophy of Science, 2007, Vol.35 (1), p.11-20

UEHARA, Ryo

2007

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MEK/ERK‐mediated oncogenic signals promote secretion of extracellular vesicles by controlling lysosome function

Asteltoxin inhibits extracellular vesicle production through AMPK/mTOR-mediated activation of lysosome function

The way forward for neuroethics in Japan: A review of five topics surrounding present challenges

Val143 of human ribonuclease H2 is not critical for, but plays a role in determining catalytic activity and substrate specificity

Development of Wearable Sheet-Type Shear Force Sensor and Measurement System that is Insusceptible to Temperature and Pressure

Insertion loop‐mediated folding propagation governs efficient maturation of hyperthermophilic Tk‐subtilisin at high temperatures

Aicardi-Goutières syndrome gene Rnaseh2c is a metastasis susceptibility gene in breast cancer

Crystal structures of the cell‐division protein FtsZ from Klebsiella pneumoniae and Escherichia coli

Requirement of Ca2+ Ions for the Hyperthermostability of Tk-Subtilisin from Thermococcus kodakarensis

Accelerated maturation of Tk‐subtilisin by a Leu→Promutation at the C‐terminus of the propeptide, which reduces the binding of the propeptide to Tk‐subtilisin

Is Conceptual Engineering from Japan Feasible?: A Review of Conceptual Engineering Manifesto edited by Kasuhisa Todayama and Kaori Karasawa

Increase in activation rate of Pro‐Tk‐subtilisin by a single nonpolar‐to‐polar amino acid substitution at the hydrophobic core of the propeptide domain

Requirement of insertion sequence IS1 for thermal adaptation of Pro-Tk-subtilisin from hyperthermophilic archaeon

超好熱性サチライシンをモデルにみるタンパク質フォールディングの高温環境適応戦略: Tk-subtilisinと3つの挿入配列

Two RNase H2 Mutants with Differential rNMP Processing Activity Reveal a Threshold of Ribonucleotide Tolerance for Embryonic Development

Unlike the Escherichia coli counterpart, archaeal RNase HII cannot process ribose monophosphate abasic sites and oxidized ribonucleotides embedded in DNA

Crystal structure of a GH1 β‐glucosidase from Hamamotoa singularis

Cognitive Enhancement and Destruction of the Self

Formation of the High-Affinity Calcium Binding Site in Pro-subtilisin E with the Insertion Sequence IS1 of Pro-Tk-subtilisin

Requirement of Ca(2+) ions for the hyperthermostability of Tk-subtilisin from Thermococcus kodakarensis

超好熱性サチライシンをモデルにみるタンパク質フォールディングの高温環境適応戦略: Tk-subtilisinと3つの挿入配列

Accelerated maturation of Tk‐subtilisin by a L eu→ P romutation at the C ‐terminus of the propeptide, which reduces the binding of the propeptide to T k‐subtilisin

Requirement of Ca 2+ Ions for the Hyperthermostability of Tk-Subtilisin from Thermococcus kodakarensis

Construction of a supermicro sense of force feedback and vision for micro-objects: development of a haptic device

Placing Knowledge in the World

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