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Model-based Drug Development

Clinical pharmacology and therapeutics, 2007-07, Vol.82 (1), p.21-32

2007

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Pharmacokinetics and pharmacodynamics of SB-240563, a humanized monoclonal antibody directed to human interleukin-5, in monkeys

The Journal of pharmacology and experimental therapeutics, 1999-12, Vol.291 (3), p.1060

1999

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Assessment of the Potential Pharmacokinetic and Pharmacodynamic Interactions between Erythromycin and Argatroban

Journal of clinical pharmacology, 1999-05, Vol.39 (5), p.513-519

1999

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Paroxetine does not affect the cardiac safety and pharmacokinetics of terfenadine in healthy adult men

Journal of clinical psychopharmacology, 1997-12, Vol.17 (6), p.451-459

1997

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Pharmacokinetics and pharmacodynamics of a humanized monoclonal antibody to factor IX in cynomolgus monkeys

The Journal of pharmacology and experimental therapeutics, 2000-02, Vol.292 (2), p.810

2000

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Influence of NSAID-Induced Inhibition of Renal Prostaglandin Synthesis on Inorganic Sulfate Clearance in Rats

Experimental biology and medicine (Maywood, N.J.), 1992-04, Vol.199 (4), p.410-416

1992

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An Overview of the Pharmacokinetics of Cilomilast (Ariflo®), a New, Orally Active Phosphodiesterase 4 Inhibitor, in Healthy Young and Elderly Volunteers

Journal of clinical pharmacology, 2001-09, Vol.41 (9), p.950-958

2001

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PHARMACOKINETICS AND ABSOLUTE BIOAVAILABILITY OF EPRISTERIDE IN HEALTHY MALE SUBJECTS

Biopharmaceutics & drug disposition, 1996-04, Vol.17 (3), p.249-258

1996

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Accumulation of Antibody-Target Complexes and the Pharmacodynamics of Clotting after Single Intravenous Administration of Humanized Anti-Factor IX Monoclonal Antibody to Rats

Drug delivery, 1999, Vol.6 (3), p.171-179

1999

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OIII-A-2

Clinical pharmacology and therapeutics, 2006-02, Vol.79 (2), p.P29-P29

2006

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Pharmacokinetic and pharmacodynamic modeling of humanized anti-factor IX antibody (SB 249417) in humans

Clinical pharmacology and therapeutics, 2002-04, Vol.71 (4), p.235-245

2002

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Nonlinear Pharmacokinetics and Protein Binding of Tiaprofenic Acid in Female Lewis Rats

Journal of pharmaceutical sciences, 1993-04, Vol.82 (4), p.429-430

1993

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OIII-A-4

Clinical pharmacology and therapeutics, 2006-02, Vol.79 (2), p.P29-P29

2006

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An Overview of the Pharmacokinetics of Cilomilast (Ariflo®), a New, Orally Active Phosphodiesterase 4 Inhibitor, in Healthy Young and Elderly Volunteers

Journal of clinical pharmacology, 2001-09, Vol.41 (9), p.950-958

2001

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Pharmacokinetics and pharmacodynamics of azithromycin in gerbils with haemophilus influenzae middle ear infection

Clinical pharmacology and therapeutics, 2005-02, Vol.77 (2), p.P89-P89

2005

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Nonlinear mixed effects modeling of time dependencies in drug-free ECG data from healthy volunteers

Clinical pharmacology and therapeutics, 2004-02, Vol.75 (2), p.P97-P97

2004

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Population pharmacokinetic and pharmacodynamic model of CP-101,606 following a 72-hour infusion in acute ischemic stroke patients

Clinical pharmacology and therapeutics, 2004-02, Vol.75 (2), p.P97-P97

2004

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Concentration-QTC modeling in healthy volunteers (HV) and in subjects with major depressive disorder (MDD) for a novel antidepressant candidate

Clinical pharmacology and therapeutics, 2004-02, Vol.75 (2), p.P88-P88

2004

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VEGF-induced phosphorylation of Bcl-2 influences B lineage leukemic cell response to apoptotic stimuli

Leukemia, 2005-03, Vol.19 (3), p.344-353

2005

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Activation of Transforming Growth Factor- beta 1/p38/Smad3 Signaling in Stromal Cells Requires Reactive Oxygen Species-Mediated MMP-2 Activity During Bone Marrow Damage

Stem cells (Dayton, Ohio), 2005-09, Vol.23 (8), p.1122-1134

2005

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OIII-A-4Population PK/PD evaluation of the QTcF interval-drug concentration relationship in healthy volunteers: A case study

Clinical pharmacology and therapeutics, 2006-02, Vol.79 (2), p.P29-P29

2006

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OIII-A-2Performance characteristics of the analysis method for “thorough QT” studies in ICH E-14

Clinical pharmacology and therapeutics, 2006-02, Vol.79 (2), p.P29-P29

2006

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Model-based Drug Development

Pharmacokinetics and pharmacodynamics of SB-240563, a humanized monoclonal antibody directed to human interleukin-5, in monkeys

Assessment of the Potential Pharmacokinetic and Pharmacodynamic Interactions between Erythromycin and Argatroban

Paroxetine does not affect the cardiac safety and pharmacokinetics of terfenadine in healthy adult men

Pharmacokinetics and pharmacodynamics of a humanized monoclonal antibody to factor IX in cynomolgus monkeys

Influence of NSAID-Induced Inhibition of Renal Prostaglandin Synthesis on Inorganic Sulfate Clearance in Rats

An Overview of the Pharmacokinetics of Cilomilast (Ariflo®), a New, Orally Active Phosphodiesterase 4 Inhibitor, in Healthy Young and Elderly Volunteers

PHARMACOKINETICS AND ABSOLUTE BIOAVAILABILITY OF EPRISTERIDE IN HEALTHY MALE SUBJECTS

Accumulation of Antibody-Target Complexes and the Pharmacodynamics of Clotting after Single Intravenous Administration of Humanized Anti-Factor IX Monoclonal Antibody to Rats

OIII-A-2

Pharmacokinetic and pharmacodynamic modeling of humanized anti-factor IX antibody (SB 249417) in humans

Nonlinear Pharmacokinetics and Protein Binding of Tiaprofenic Acid in Female Lewis Rats

OIII-A-4

An Overview of the Pharmacokinetics of Cilomilast (Ariflo®), a New, Orally Active Phosphodiesterase 4 Inhibitor, in Healthy Young and Elderly Volunteers

Pharmacokinetics and pharmacodynamics of azithromycin in gerbils with haemophilus influenzae middle ear infection

Nonlinear mixed effects modeling of time dependencies in drug-free ECG data from healthy volunteers

Population pharmacokinetic and pharmacodynamic model of CP-101,606 following a 72-hour infusion in acute ischemic stroke patients

Concentration-QTC modeling in healthy volunteers (HV) and in subjects with major depressive disorder (MDD) for a novel antidepressant candidate

Minipig as a potential translatable model for monoclonal antibody pharmacokinetics after intravenous and subcutaneous administration

VEGF-induced phosphorylation of Bcl-2 influences B lineage leukemic cell response to apoptotic stimuli

Activation of Transforming Growth Factor- beta 1/p38/Smad3 Signaling in Stromal Cells Requires Reactive Oxygen Species-Mediated MMP-2 Activity During Bone Marrow Damage

OIII-A-4Population PK/PD evaluation of the QTcF interval-drug concentration relationship in healthy volunteers: A case study

OIII-A-2Performance characteristics of the analysis method for “thorough QT” studies in ICH E-14

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